Reference on EC 1.14.16.4 - tryptophan 5-monooxygenase and Organism(s) Mus musculus and UniProt Accession P17532
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hasegawa, H.; Ichiyama, A.
Tryptophan 5-monooxygenase from mouse mastocytoma: high-performance liquid chromatography assay
Methods Enzymol.
142
88-92
1987
Mus musculus
Fujisawa, H.; Nakata, H.
Tryptophan 5-monooxygenase from mouse mastocytoma clone P815
Methods Enzymol.
142
93-96
1987
Mus musculus
Nakata, H.; Fujisawa, H.
Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties
Eur. J. Biochem.
124
595-601
1982
Mus musculus
Naoi, M.; Maruyama, W.; Takahashi, T.; Ota, M.; Parvez, H.
Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids
Biochem. Pharmacol.
48
207-211
1994
Mus musculus
Park, D.H.; Stone, D.M.; Kim, K.S.; Joh, T.H.
Characterization of recombinant mouse tryptophan hydroxylase expressed in Escherichia coli
Mol. Cell. Neurosci.
5
87-93
1994
Mus musculus, Rattus norvegicus
Yohrling, I.G.; Jiang, G.C.; DeJohn, M.M.; Robertson, D.J.; Vrana, K.E.; Cha, J.H.
Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease
J. Neurochem.
82
1416-1423
2002
Mus musculus
Walther, D.J.; Peter, J.U.; Bashammakh, S.; Hortnagl, H.; Voits, M.; Fink, H.; Bader, M.
Synthesis of serotonin by a second tryptophan hydroxylase isoform
Science
299
76
2003
Mus musculus (Q8CGV2)
Zhang, X.; Beaulieu, J.M.; Sotnikova, T.D.; Gainetdinov, R.R.; Caron, M.G.
Tryptophan hydroxylase-2 controls brain serotonin synthesis
Science
305
217
2004
Mus musculus (Q8CGV2), Mus musculus
Hasegawa, H.; Ichiyama, A.
Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron
Biochem. Biophys. Res. Commun.
338
277-284
2005
Homo sapiens, Mus musculus
Zhang, X.; Beaulieu, J.M.; Gainetdinov, R.R.; Caron, M.G.
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2
Cell. Mol. Life Sci.
63
6-11
2006
Danio rerio, Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Cervo, L.; Canetta, A.; Calcagno, E.; Burbassi, S.; Sacchetti, G.; Caccia, S.; Fracasso, C.; Albani, D.; Forloni, G.; Invernizzi, R.W.
Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
J. Neurosci.
25
8165-8172
2005
Mus musculus
Izikki, M.; Hanoun, N.; Marcos, E.; Savale, L.; Barlier-Mur, A.M.; Saurini, F.; Eddahibi, S.; Hamon, M.; Adnot, S.
Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice
Am. J. Physiol. Lung Cell. Mol. Physiol.
293
L1045-L1052
2007
Mus musculus
Niimi, K.; Takahashi, E.; Itakura, C.
Emotional behavior and expression patterns of tyrosine hydroxylase and tryptophan hydroxylase in senescence-accelerated mouse (SAM) P6 mice
Behav. Brain Res.
188
329-336
2008
Mus musculus
Shi, Z.C.; Devasagayaraj, A.; Gu, K.; Jin, H.; Marinelli, B.; Samala, L.; Scott, S.; Stouch, T.; Tunoori, A.; Wang, Y.; Zang, Y.; Zhang, C.; Kimball, S.D.; Main, A.J.; Sun, W.; Yang, Q.; Nouraldeen, A.; Yu, X.Q.; Buxton, E.; Patel, S.; Nguyen, N.; Swaffield, J.; Powell, D.R.; Wilson, A.; Liu, Q.
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders
J. Med. Chem.
51
3684-3687
2008
Mus musculus
Calcagno, E.; Canetta, A.; Guzzetti, S.; Cervo, L.; Invernizzi, R.W.
Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity
J. Neurochem.
103
1111-1120
2007
Mus musculus
Liu, Q.; Yang, Q.; Sun, W.; Vogel, P.; Heydorn, W.; Yu, X.Q.; Hu, Z.; Yu, W.; Jonas, B.; Pineda, R.; Calderon-Gay, V.; Germann, M.; ONeill, E.; Brommage, R.; Cullinan, E.; Platt, K.; Wilson, A.; Powell, D.; Sands, A.; Zambrowicz, B.; Shi, Z.C.
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
J. Pharmacol. Exp. Ther.
325
47-55
2008
Mus musculus
Peter, J.; Alenina, N.; Bader, M.; Walther, D.J.
Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
Mol. Cell. Biochem.
295
205-215
2007
Mus musculus
Nakamura, K.; Hasegawa, H.
Developmental role of tryptophan hydroxylase in the nervous system
Mol. Neurobiol.
35
45-54
2007
Mus musculus (P17532), Mus musculus (Q8CGV2), Homo sapiens (P17752), Homo sapiens (Q8IWU9)
Clark, J.A.; Flick, R.B.; Pai, L.Y.; Szalayova, I.; Key, S.; Conley, R.K.; Deutch, A.Y.; Hutson, P.H.; Mezey, E.
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice
Mol. Psychiatry
13
498-506
2008
Homo sapiens (Q8IWU9), Homo sapiens, Mus musculus, Mus musculus C57BL/6, Rattus norvegicus (Q8CGU9)
Kulikov, A.V.; Osipova, D.V.; Popova, N.K.
The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain
Russ. J. Genet.
43
1408-1412
2007
Mus musculus (Q8CGV2)
-
Jin, H.; Cianchetta, G.; Devasagayaraj, A.; Gu, K.; Marinelli, B.; Samala, L.; Scott, S.; Stouch, T.; Tunoori, A.; Wang, Y.; Zang, Y.; Zhang, C.; David Kimball, S.; Main, A.J.; Ding, Z.M.; Sun, W.; Yang, Q.; Yu, X.Q.; Powell, D.R.; Wilson, A.; Liu, Q.; Shi, Z.C.
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors
Bioorg. Med. Chem. Lett.
19
5229-5232
2009
Mus musculus, Homo sapiens (P17752)
Heydendael, W.; Jacobson, L.
Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphe tryptophan hydroxylase gene expression
Brain Res.
1288
69-78
2009
Mus musculus
Kuhn, D.M.; Sykes, C.E.; Geddes, T.J.; Jaunarajs, K.L.; Bishop, C.
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinsons disease
J. Neurochem.
116
426-437
2011
Mus musculus
Matthes, S.; Mosienko, V.; Bashammakh, S.; Alenina, N.; Bader, M.
Tryptophan hydroxylase as novel target for the treatment of depressive disorders
Pharmacology
85
95-109
2010
Homo sapiens, Mus musculus
Nowak, E.C.; de Vries, V.C.; Wasiuk, A.; Ahonen, C.; Bennett, K.A.; Le Mercier, I.; Ha, D.G.; Noelle, R.J.
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
J. Exp. Med.
209
2127-2135
2012
Mus musculus
Laurent, L.; Deroy, K.; St-Pierre, J.; Cote, F.; Sanderson, J.T.; Vaillancourt, C.
Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase
Biochimie
140
159-165
2017
Homo sapiens, Mus musculus
