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11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
-
-
-
?
11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
11-deoxycorticosterone + reduced ferredoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized ferredoxin + H2O
ferredoxin from the cyanobacterium Anabaena PCC 7119
-
-
?
11-deoxycorticosterone + reduced flavodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized flavodoxin + H2O
flavodoxin from the cyanobacterium Anabaena PCC 7119
-
-
?
11-deoxycortisol + reduced adrenodoxin + O2
15beta-15,17,21-trihydroxypregn-4-ene-3,20-dione + oxidized adrenodoxin + H2O
adrenodoxin is a [2Fe-2S] ferredoxin involved in electron transfer from NADPH+ (via a reductase) to cytochrome P-450 in the adrenal gland
-
-
?
11-deoxycortisol + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycortisol + oxidized adrenodoxin + H2O
-
-
-
?
11beta-hydroxy-4-androstene-3,17-dione + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
17alpha-methyltestosterone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
19-nortestosterone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
4-androstene-3,17-dione + reduced adrenodoxin + O2
15beta-hydroxyandrostene-3,17-dione + oxidized adrenodoxin + H2O
-
-
-
?
6alpha-fluoro-16alpha-methyl-deoxycorticosterone + reduced ferredoxin + O2
15beta-hydroxy-6alpha-fluoro-16alpha-methyl-deoxycorticosterone + oxidized ferredoxin + H2O
-
-
-
?
abietic acid + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
binding of abietic acid results in a type II difference spectrum typical for nitrogenous inhibitors
-
-
?
corticosterone + reduced adrenodoxin + O2
15beta-hydroxycorticosterone + oxidized adrenodoxin + H2O
-
-
-
?
cortisone + reduced adrenodoxin + O2
15beta-hydroxycortisone + oxidized adrenodoxin + H2O
-
-
-
?
dehydroabietic acid + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
dehydroepiandrosterone + reduced adrenodoxin + O2
7beta-hydroxy-dehydroepiandrosterone + oxidized adrenodoxin + H2O
-
-
-
?
deoxycorticosterone + reduced ferredoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized ferredoxin + H2O
-
-
-
r
deoxycorticosterone + reduced flavodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized flavodoxin + H2O
-
-
-
r
dexamethasone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
digitoxigenin + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
isopimaric acid + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
prednisolone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
prednisone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
pregnenolone + reduced adrenodoxin + O2
7beta-hydroxy-pregnenolone + oxidized adrenodoxin + H2O
-
-
-
?
progesterone + reduced adrenodoxin + O2
15beta-hydroxy-progesterone + 11alpha-hydroxy-progesterone + oxidized adrenodoxin + H2O
-
-
-
?
progesterone + reduced adrenodoxin + O2
15beta-hydroxy-progesterone + oxidized adrenodoxin + H2O
adrenodoxin is a [2Fe-2S] ferredoxin involved in electron transfer from NADPH+ (via a reductase) to cytochrome P-450 in the adrenal gland, 15beta-hydroxy-progesterone is the main product of wild-type enzyme and all mutants. In order to gain insights into the structure and function of CYP106A2, whose crystal structure is unknown, a homology model has been created. The substrate progesterone is then docked into the active site to predict which residues might affect substrate binding. The model is substantiated by using a combination of theoretical and experimental investigations
-
-
?
progesterone + reduced adrenodoxin + O2
15beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
progesterone + reduced ferredoxin + O2
15beta-hydroxy-progesterone + oxidized ferredoxin + H2O
Bacillus megaterium ferredoxin may be replaced by adrenal ferredoxin
-
-
?
progesterone + reduced megaredoxin + O2
15beta-hydroxyprogesterone + oxidized megaredoxin + H2O
-
-
-
?
testosterone + reduced adrenodoxin + O2
15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
-
-
-
?
11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
-
-
-
-
?
11-deoxycorticosterone + reduced megaredoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
11-deoxycortisol + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycortisol + oxidized adrenodoxin + H2O
-
-
-
?
11-oxo-beta-boswellic acid + reduced ferredoxin + O2
(3alpha,15beta)-3,15-dihydroxy-11-oxours-12-en-24-oic acid + H2O
-
a pentacyclic triterpene, 15beta-hydroxylation
-
-
?
11beta-hydroxy-4-androstene-3,17-dione + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
17alpha-hydroxyprogesterone + reduced megaredoxin + O2
(15beta,17alpha)-15,17-dihydroxyprogesterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
17alpha-methyltestosterone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
19-nortestosterone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
20alpha-dihydroprogesterone + reduced megaredoxin + O2
(15beta,20alpha)-15-hydroxy-20-dihydroprogesterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
4-androstene-3,17-dione + reduced megaredoxin + O2
15beta-hydroxyandrostene-3,17-dione + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
abietic acid + reduced adrenodoxin + O2
12-hydroxyabietic acid + oxidized adrenodoxin + H2O
-
-
-
-
?
abietic acid + reduced ferredoxin + O2
?
-
a pentacyclic triterpene
-
-
?
corticosterone + reduced megaredoxin + O2
15beta-hydroxycorticosterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, preferred substrate, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
cortisone + reduced adrenodoxin + O2
15beta-hydroxycortisone + oxidized adrenodoxin + H2O
-
-
-
?
dexamethasone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
imipramine + reduced adrenodoxin + O2
desipramine + oxidized adrenodoxin + H2O
-
-
-
-
?
prednisolone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
prednisone + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
-
-
-
?
progesterone + reduced megaredoxin + O2
15beta-hydroxyprogesterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
testosterone + reduced acceptor + O2
15beta-hydroxytestosterone + oxidized acceptor + H2O
-
the major product is identified as 15beta-hydroxytestosterone. 6beta-Hydroxytestosterone and androst-4-ene-3,17-dione are present as minor products
-
-
?
testosterone + reduced adrenodoxin + O2
15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
-
-
-
?
testosterone + reduced megaredoxin + O2
15beta-hydroxytestosterone + oxidized megaredoxin + H2O
-
megaredoxin is an iron-sulfur protein of Bacillus megaterium, megaredoxin has an apparent sulfur to iron ratio of 0.98
-
-
?
additional information
?
-
11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
adrenodoxin is a [2Fe-2S] ferredoxin involved in electron transfer from NADPH+ (via a reductase) to cytochrome P-450 in the adrenal gland, 15beta-hydroxy-deoxycorticosterone is the only product that is observed, both in the case of wild-type CYP106A2 and all the mutants (except T396R)
-
-
?
11-deoxycorticosterone + reduced adrenodoxin + O2
15beta-hydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
deoxycorticosterone binds in the heme pocket near the iron ligand
-
-
?
progesterone + reduced adrenodoxin + O2
15beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
adrenodoxin is a [2Fe-2S] ferredoxin involved in electron transfer from NADPH+ (via a reductase) to cytochrome P-450 in the adrenal gland
-
-
?
progesterone + reduced adrenodoxin + O2
15beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
identification of monohydroxy progesterones using comparative HPLC and electrospray ionisation collision-induced dissociation mass spectrometry. 15beta-Hydroxy-progesterone is the main product. 6beta-Hydroxyprogesterone, 11alpha-hydroxyprogesterone, and 9alpha-hydroxyprogesterone are formed at small amounts
-
-
?
testosterone + reduced adrenodoxin + O2
15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
-
-
-
?
testosterone + reduced adrenodoxin + O2
15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
-
-
-
?
additional information
?
-
the specificity of hydroxylation in beta-position can be altered by the choice of the electron transfer system. Replacing the natural electron transfer partners by peroxides, the ratio of 15alpha-/15beta-hydroxylation of progesterone is increased 1.3fold
-
-
?
additional information
?
-
CYP106A2 catalyzes hydroxylations of a variety of 3-oxo-D4-steroids such as progesterone and deoxycorticosterone, mainly in the 15beta-position. The diterpene resin acid abietic acid is a substrate, that is converted to 12alpha- and 12beta-hydroxyabietic acid, catalytic site binding structure, homology modelling, overview
-
-
?
additional information
?
-
high-throughput substrate screening and binding affinities, substrate docking, overview
-
-
?
additional information
?
-
-
enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha, and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione
-
-
?
additional information
?
-
enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha, and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione
-
-
?
additional information
?
-
the 3-oxo-DELTA4 moiety is not crucial for steroid conversion with CYP106A2. No substrates: estrone, estradiol, stigmasterol, and cholesterol
-
-
?
additional information
?
-
-
hydroxylates a variety of 3-oxo-DELTA4-steroids in position 15beta in the presence of NADPH and O2. Ring A-reduced, aromatic, and 3beta-hydroxy-DELTA4-steroids do not serve as substrates
-
-
?
additional information
?
-
-
CYP106A2 from hydroxylates a variety of 3-oxo-DELTA4 steroids and catalyzes a one-step regioselective allylic hydroxylation of the diterpene abietic acid
-
-
?
additional information
?
-
-
enzyme reaction is coupled to NADPH oxidation, overview
-
-
?
additional information
?
-
-
enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha,and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione
-
-
?
additional information
?
-
enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha,and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione
-
-
?
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0.037 - 0.093
11-deoxycortisol
0.0012 - 0.0056
deoxycorticosterone
0.0007 - 0.251
progesterone
0.00314
reduced ferredoxin
pH 7.4, 30°C, wild-type ferredoxin from the cyanobacterium Anabaena PCC 7119
0.00734
reduced flavodoxin
pH 7.4, 30°C, wild-type flavodoxin from the cyanobacterium Anabaena PCC 7119
0.56
17alpha-hydroxyprogesterone
-
22°C
0.45
20alpha-dihydroprogesterone
-
22°C
0.625
4-androstene-3,17-dione
-
22°C
0.095
corticosterone
-
22°C
0.06
deoxycorticosterone
-
22°C
0.143
progesterone
-
22°C
additional information
additional information
-
0.037
11-deoxycortisol
pH 7.4, 30°C, mutant A106T/Q189K/T399S/R409L, mutant D153V/I214F
0.059
11-deoxycortisol
pH 7.4, 30°C, mutant A106T
0.066
11-deoxycortisol
pH 7.4, 30°C, mutant D217V
0.068
11-deoxycortisol
pH 7.4, 30°C, mutant A106T/R409L
0.093
11-deoxycortisol
pH 7.4, 30°C, CYP106A2 wild-type enzyme
0.0012
deoxycorticosterone
pH 7.4, 30°C, mutant I86T
0.0015
deoxycorticosterone
pH 7.4, 30°C, wild-type enzyme
0.0019
deoxycorticosterone
pH 7.4, 30°C, mutant E90V/D185G
0.0024
deoxycorticosterone
pH 7.4, 30°C, mutant K27R/I71T/I215T
0.0042
deoxycorticosterone
pH 7.4, 30°C, mutant A395L
0.0046
deoxycorticosterone
pH 7.4, 30°C, mutant G397P
0.0047
deoxycorticosterone
pH 7.4, 30°C, mutant S394I
0.0056
deoxycorticosterone
pH 7.4, 30°C, mutant Q398S
0.0007
progesterone
pH 7.4, 30°C, mutant K27R/I71T/I215T
0.0009
progesterone
pH 7.4, 30°C, mutant I86T
0.001
progesterone
pH 7.4, 30°C, mutant E90V/D185G
0.0015
progesterone
pH 7.4, 30°C, wild-type enzyme
0.0024
progesterone
pH 7.4, 30°C, mutant A395L
0.0043
progesterone
pH 7.4, 30°C, mutant S394I
0.0049
progesterone
pH 7.4, 30°C, mutant Q398S
0.005
progesterone
pH 7.4, 30°C, mutant G397P
0.251
progesterone
pH 7.4, 30°C, for determination of Km-value the formation of the product 15beta-hydroxy-progesterone is determined
additional information
additional information
KM-value for the deoxicorticosterone 15beta-hydroxylase activity of recombinant BmCYP106A2 when using the NADPH/Anabaena ferredoxin electron donor system and different electron carrier proteins. Use of different AnFld mutants at positions W57, I59 and I92, which alter their aromatic and hydrophobic character, as electron donor to BmCYP106A2
-
additional information
additional information
-
KM-value for the deoxicorticosterone 15beta-hydroxylase activity of recombinant BmCYP106A2 when using the NADPH/Anabaena ferredoxin electron donor system and different electron carrier proteins. Use of different AnFld mutants at positions W57, I59 and I92, which alter their aromatic and hydrophobic character, as electron donor to BmCYP106A2
-
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Virus, C.; Bernhardt, R.
Molecular evolution of a steroid hydroxylating cytochrome P450 using a versatile steroid detection system for screening
Lipids
43
1133-1141
2008
Priestia megaterium (Q06069)
brenda
Simgen, B.; Contzen, J.; Schwarzer, R.; Bernhardt, R.; Jung, C.
Substrate binding to 15beta-hydroxylase (CYP106A2) probed by FT infrared spectroscopic studies of the iron ligand CO stretch vibration
Biochem. Biophys. Res. Commun.
269
737-742
2000
Priestia megaterium (Q06069)
brenda
Lisurek, M.; Kang, M.J.; Hartmann, R.W.; Bernhardt, R.
Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray ionisation collision-induced dissociation mass spectrometry
Biochem. Biophys. Res. Commun.
319
677-682
2004
Priestia megaterium (Q06069)
brenda
Virus, C.; Lisurek, M.; Simgen, B.; Hannemann, F.; Bernhardt, R.
Function and engineering of the 15beta-hydroxylase CYP106A2
Biochem. Soc. Trans.
34
1215-1218
2006
Priestia megaterium (Q06069)
brenda
Goni, G.; Zllner, A.; Lisurek, M.; Velazquez-Campoy, A.; Pinto, S.; Gomez-Moreno, C.; Hannemann, F.; Bernhardt, R.; Medina, M.
Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368
Biochim. Biophys. Acta
1794
1635-1642
2009
Priestia megaterium (Q06069), Priestia megaterium
brenda
Zehentgruber, D.; Hannemann, F.; Bleif, S.; Bernhardt, R.; Ltz, S.
Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2.
Chembiochem
11
713-721
2010
Priestia megaterium (Q06069)
brenda
Lisurek, M.; Simgen, B.; Antes, I.; Bernhardt, R.
Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation
Chembiochem
16
1439-1449
2008
Priestia megaterium (Q06069)
brenda
Berg, A.; Gustafsson, J.A.; Ingelman-Sundberg, M.
Characterization of a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium
J. Biol. Chem.
251
2831-2838
1976
Priestia megaterium
brenda
Berg, A.; Ingelman-Sundberg, M.; Gustafsson, M.
Purification and characterization of cytochrome P-450meg
J. Biol. Chem.
254
5264-5271
1979
Priestia megaterium (Q06069)
brenda
Ruijssenaars, H.J.; Sperling, E.M.; Wiegerinck, P.H.; Brands, F.T.; Wery, J.; de Bont, J.A.
Testosterone 15beta-hydroxylation by solvent tolerant Pseudomonas putida S12
J. Biotechnol.
131
205-208
2007
Priestia megaterium
brenda
Rauschenbach, R.; Isernhagen, M.; Noeske-Jungblut, C.; Boidol, W.; Siewert, G.
Cloning sequencing and expression of the gene for cytochrome P450meg, the steroid-15 beta-monooxygenase from Bacillus megaterium ATCC 13368
Mol. Gen. Genet.
241
170-176
1993
Priestia megaterium (Q06069)
brenda
Bleif, S.; Hannemann, F.; Lisurek, M.; Von Kries, J.; Zapp, J.; Dietzen, M.; Antes, I.; Bernhardt, R.
Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase
ChemBioChem
12
576-582
2011
Priestia megaterium (Q06069), Priestia megaterium ATCC 13368 (Q06069)
brenda
Bleif, S.; Hannemann, F.; Zapp, J.; Hartmann, D.; Jauch, J.; Bernhardt, R.
A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-beta-boswellic acid (KBA) based on a recombinant cytochrome P450 system
Appl. Microbiol. Biotechnol.
93
1135-1146
2012
Priestia megaterium, Priestia megaterium ATCC 13368
brenda
Schumacher, S.D.; Hannemann, F.; Teese, M.G.; Bernhardt, R.; Jose, J.
Autodisplay of functional CYP106A2 in Escherichia coli
J. Biotechnol.
161
104-112
2012
Priestia megaterium
brenda
Kiss, F.M.; Schmitz, D.; Zapp, J.; Dier, T.K.; Volmer, D.A.; Bernhardt, R.
Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity
Appl. Microbiol. Biotechnol.
99
8495-8514
2015
Priestia megaterium, Priestia megaterium (Q06069)
brenda
Janocha, S.; Carius, Y.; Hutter, M.; Lancaster, C.R.; Bernhardt, R.
Crystal structure of CYP106A2 in substrate-free and substrate-bound form
ChemBioChem
17
852-860
2016
Priestia megaterium (Q06069)
brenda
Schmitz, D.; Zapp, J.; Bernhardt, R.
Steroid conversion with CYP106A2 - production of pharmaceutically interesting DHEA metabolites
Microb. Cell Fact.
13
81
2014
Priestia megaterium (Q06069)
brenda
Nikolaus, J.; Nguyen, K.T.; Virus, C.; Riehm, J.L.; Hutter, M.; Bernhardt, R.
Engineering of CYP106A2 for steroid 9alpha- and 6beta-hydroxylation
Steroids
120
41-48
2017
Priestia megaterium (Q06069)
brenda