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3(or 17)beta-hydroxysteroid dehydrogenase deficiency
17 alpha-hydroxylation deficiency.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Genetic diseases of steroid metabolism.
3beta-hydroxy-delta5-steroid dehydrogenase deficiency
Steroidogenesis of the testis -- new genes and pathways.
Abortion, Spontaneous
Association between LRH-1 single nucleotide polymorphisms and unexplained recurrent spontaneous abortion in Chinese Han couples.
Abortion, Spontaneous
Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StAR.
Addison Disease
A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison's disease).
Addison Disease
A Novel Homozygous Mutation in CYP11A1 Gene is Associated with Severe Adrenal Insufficiency in 46, XX Patient.
Addison Disease
Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene.
Addison Disease
Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.
Addison Disease
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Addison Disease
Autoantibodies in autoimmune polyendocrine syndrome type II.
Addison Disease
Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.
Addison Disease
Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure.
Addison Disease
Characterization of adrenal autoantigens recognized by sera from patients with autoimmune polyglandular syndrome (APS) type I.
Addison Disease
Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency.
Addison Disease
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.
Addison Disease
Normal male external genitalia do not rule out CYP11A1 deficiency.
Addison Disease
Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing.
Adenoma
A Dispensable Role for P450(scc) in the Overproduction of Aldosterone in Aldosterone-Producing Adenoma and Idiopathic Hyperaldosteronism in Patients with Primary Aldosteronism.
Adenoma
ACTH-independent macronodular adrenocortical hyperplasia: immunohistochemical and in situ hybridization studies of steroidogenic enzymes.
Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adenoma
Expression of adrenocorticotrophic hormone receptor mRNA in human adrenocortical neoplasms: correlation with P450scc expression.
Adenoma
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol.
Adenoma
Expression of steroidogenic enzyme messenger ribonucleic acids and corticosteroid production in aldosterone-producing and "nonfunctioning" adrenal adenomas.
Adenoma
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Adenoma
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
Adrenal Gland Neoplasms
Steroidogenic acute regulatory protein mRNA expression in adrenal tumours.
Adrenal Hyperplasia, Congenital
Evidence of a steroidogenic enzyme gene dose effect on adrenal gene expression in hereditary rabbit congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme.
Adrenal Hyperplasia, Congenital
Inherited congenital adrenal hyperplasia in the rabbit: absent cholesterol side-chain cleavage cytochrome P450 gene expression.
Adrenal Hyperplasia, Congenital
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.
Adrenal Hyperplasia, Congenital
Molecular genetics of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Novel SCC mutation in a patient of Mexican descent with sex reversal, salt-losing crisis and adrenal failure.
Adrenal Hyperplasia, Congenital
P450scc deficiency (congenital lipoid adrenal hyperplasia): first reported case in Thailand and literature review.
Adrenal Insufficiency
A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.
Adrenal Insufficiency
A Novel Homozygous Mutation in CYP11A1 Gene is Associated with Severe Adrenal Insufficiency in 46, XX Patient.
Adrenal Insufficiency
A Novel Intronic Splice-Site Mutation of the CYP11A1 Gene Linked to Adrenal Insufficiency with 46,XY Disorder of Sex Development.
Adrenal Insufficiency
A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.
Adrenal Insufficiency
Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.
Adrenal Insufficiency
Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency.
Adrenal Insufficiency
Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans.
Adrenal Insufficiency
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
Adrenal Insufficiency
First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic.
Adrenal Insufficiency
Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.
Adrenal Insufficiency
Heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A1) can cause transient adrenal insufficiency and life-threatening failure to thrive.
Adrenal Insufficiency
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Adrenal Insufficiency
Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide.
Adrenal Insufficiency
Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposure.
Adrenocortical Adenoma
Steroidogenic acute regulatory protein mRNA expression in adrenal tumours.
Adrenocortical Carcinoma
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Adrenocortical Carcinoma
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
Adrenocortical Carcinoma
Expression of adrenocorticotrophic hormone receptor mRNA in human adrenocortical neoplasms: correlation with P450scc expression.
Adrenocortical Carcinoma
In vitro studies of the adrenal metabolism of halogenated side-chain analogues of cholesterol.
Agenesis of Corpus Callosum
Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum.
Anaphylaxis
Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children.
Anaphylaxis
The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.
Androgen-Insensitivity Syndrome
Aetiological bases of 46,XY disorders of sex development in the Hong Kong Chinese population.
Angelman Syndrome
Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.
Asthma
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Autoimmune Diseases
Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease.
Breast Diseases
Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women.
Breast Neoplasms
A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.
Breast Neoplasms
Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk.
Breast Neoplasms
Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.
Breast Neoplasms
Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women.
Breast Neoplasms
Population-based case-control study of CYP11A gene polymorphism and breast cancer risk.
Breast Neoplasms
Risk-association of CYP11A1 polymorphisms and breast cancer among han chinese women in southern china.
Breast Neoplasms
The osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1 in osteoblasts.
Breast Neoplasms
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
Carcinogenesis
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
Carcinogenesis
Rodent models for studying steroids and hypertension: from fetal development to cells in culture.
Carcinoma
Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders.
Carcinoma
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Carcinoma
StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies.
Carcinoma
Steroid hormone profile of canine inflammatory mammary carcinoma: a preliminary study.
Cataract
Familial keratoconus with cataract: linkage to the long arm of chromosome 15 and exclusion of candidate genes.
Cholera
Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells.
Cholera
Follicle-stimulating hormone increases concentrations of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage enzyme in primary cultures of porcine granulosa cells.
Cholera
Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.
Cholera
Interaction of phorbol ester and adrenocorticotropin in the regulation of steroidogenic P450 genes in human fetal and adult adrenal cell cultures.
Cholera
Leptin interferes with adrenocorticotropin/3',5'-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-phosphatidylinositol 3-kinase/Akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line.
Cholera
Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin.
Cholera
Steroid regulation of progesterone synthesis in a stable porcine granulosa cell line: a role for progestins.
Cholera
Time-course effects of human recombinant luteinizing hormone on porcine Leydig cell specific differentiated functions.
Cholestasis
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
cholesterol monooxygenase (side-chain-cleaving) deficiency
17 alpha-hydroxylation deficiency.
cholesterol monooxygenase (side-chain-cleaving) deficiency
A novel entity of clinically isolated adrenal insufficiency caused by a partially inactivating mutation of the gene encoding for P450 side chain cleavage enzyme (CYP11A1).
cholesterol monooxygenase (side-chain-cleaving) deficiency
A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Aetiological bases of 46,XY disorders of sex development in the Hong Kong Chinese population.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X).
cholesterol monooxygenase (side-chain-cleaving) deficiency
First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Gonadal development and growth in 46,XX and 46,XY individuals with P450scc deficiency (congenital lipoid adrenal hyperplasia).
cholesterol monooxygenase (side-chain-cleaving) deficiency
Inherited congenital adrenal hyperplasia in the rabbit: absent cholesterol side-chain cleavage cytochrome P450 gene expression.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Normal male external genitalia do not rule out CYP11A1 deficiency.
cholesterol monooxygenase (side-chain-cleaving) deficiency
P450 side-chain cleavage deficiency--a rare cause of congenital adrenal hyperplasia.
cholesterol monooxygenase (side-chain-cleaving) deficiency
P450scc deficiency (congenital lipoid adrenal hyperplasia): first reported case in Thailand and literature review.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Partial defect in the cholesterol side-chain cleavage enzyme p450scc (CYP11A1) resembling nonclassic congenital lipoid adrenal hyperplasia.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.
cholesterol monooxygenase (side-chain-cleaving) deficiency
The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein.
cholesterol monooxygenase (side-chain-cleaving) deficiency
Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc.
cholesterol monooxygenase (side-chain-cleaving) deficiency
[Dizygotic pregnancy as a possible mechanism of fetal gestation with a biallel mutation in the CYP11A1 gene: clinical case description].
Choriocarcinoma
Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells.
Choriocarcinoma
Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs.
Choriocarcinoma
Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3.
Choriocarcinoma
Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3',5'-monophosphate response element in the human gene for P450scc.
Choriocarcinoma
Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes.
Choriocarcinoma
Regulation of cytochrome P450 cholesterol side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase type 1 and estradiol-17 beta-hydroxysteroid dehydrogenase mRNA levels by calcium in human choriocarcinoma JEG-3 cells.
Choriocarcinoma
Structural and functional changes in mitochondria associated with trophoblast differentiation: methods to isolate enriched preparations of syncytiotrophoblast mitochondria.
Colitis
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Colorectal Neoplasms
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.
Cryptorchidism
Influence of experimental cryptorchidism on cholesterol side-chain cleavage enzyme and delta5-3beta-hydroxysteroid dehydrogenase activities in rat testes.
Cysticercosis
Modified expression of steroid 5 alpha-reductase as well as aromatase, but not cholesterol side-chain cleavage enzyme, in the reproductive system of male mice during (Taenia crassiceps) cysticercosis.
Cysts
Dexamethasone-induced changes in sympathetic innervation of porcine ovaries and in their steroidogenic activity.
Cysts
Expression of steroidogenic enzymes in porcine polycystic ovaries.
Cysts
Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17?-HSD: a tissue culture approach.
Cysts
Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD: a tissue culture approach.
Deficiency Diseases
Role of mitochondria in steroidogenesis.
Dehydration
Chronic exposure to environmental cadmium affects growth and survival, cellular stress, and glucose metabolism in juvenile channel catfish (Ictalurus punctatus).
Dehydration
The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration.
Demyelinating Diseases
Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice.
Diabetes Mellitus
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Diabetes Mellitus
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies.
Diabetes Mellitus, Type 1
The effects of Tremella aurantia on testosterone and corticosterone productions in normal and diabetic rats.
Diabetes Mellitus, Type 2
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies.
Diabetes Mellitus, Type 2
The effects of Tremella aurantia on testosterone and corticosterone productions in normal and diabetic rats.
Diabetes Mellitus, Type 2
[Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
Disorder of Sex Development, 46,XY
17 alpha-hydroxylation deficiency.
Disorders of Sex Development
Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene.
Disorders of Sex Development
Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.
Disorders of Sex Development
SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1.
Endometrial Neoplasms
Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer.
Endometrial Neoplasms
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
Endometrial Neoplasms
Variants in hormone biosynthesis genes and risk of endometrial cancer.
Endometrial Neoplasms
Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer.
Endometriosis
Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.
Epilepsy
Expression of cytochrome P450scc mRNA in the hippocampus of patients with temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Expression of cytochrome P450scc mRNA in the hippocampus of patients with temporal lobe epilepsy.
Fanconi Anemia
Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads.
Fetal Growth Retardation
The expression of ovine placental lactogen, StAR and progesterone-associated steroidogenic enzymes in placentae of overnourished growing adolescent ewes.
Follicular Cyst
Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats.
Foot-and-Mouth Disease
Using a viral 2A peptide-based strategy to reconstruct the bovine P450scc steroidogenic system in S. cerevisiae: Bovine P450scc system expression using 2A peptides.
Frasier Syndrome
Aetiological bases of 46,XY disorders of sex development in the Hong Kong Chinese population.
Genetic Diseases, Inborn
Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.
Genetic Diseases, Inborn
Aetiological bases of 46,XY disorders of sex development in the Hong Kong Chinese population.
Glioma
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
Glioma
Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis.
Granulosa Cell Tumor
The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.
Hepatitis
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Hepatitis B
Registration of the protein with compact disk.
Herpes Simplex
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Herpes Zoster
Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.
Herpes Zoster
Changes in plasma concentrations of corticosterone and its precursors after ketoconazole administration in rats: An application of simultaneous measurement of multiple steroids using LC-MS/MS.
Herpes Zoster
Corticosterone regulates cell proliferation and cytochrome P450 cholesterol side-chain cleavage enzyme messenger ribonucleic acid expression in primary cultures of fetal rat adrenals.
Herpes Zoster
Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies.
Herpes Zoster
Effects of acrolein on the production of corticosterone in male rats.
Herpes Zoster
Effects of S-petasin on cyclic AMP production and enzyme activity of P450scc in rat zona fasciculata-reticularis cells.
Herpes Zoster
Glucocorticoids and aging.
Herpes Zoster
Immunohistochemical localisation of steroidogenic enzymes and phenylethanolamine-N-methyl-transferase (PNMT) in the adrenal gland of the fetal and newborn foal.
Herpes Zoster
In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal.
Herpes Zoster
Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.
Herpes Zoster
Inhibitory effects of bromocriptine on corticosterone secretion in male rats.
Herpes Zoster
Involvement of adenosine monophosphate activated kinase in interleukin-6 regulation of steroidogenic acute regulatory protein and cholesterol side chain cleavage enzyme in the bovine zona fasciculata and zona reticularis.
Herpes Zoster
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
Herpes Zoster
Mechanisms of inhibition of dehydroepiandrosterone upon corticosterone release from rat zona fasciculata-reticularis cells.
Herpes Zoster
Monoclonal antibodies against bovine adrenal cytochrome P-450(11 beta) and cytochrome P-450SCC. Their isolation, characterization and application to immunohistochemical analysis of adrenal cortex.
Herpes Zoster
Potassium induces multiple steroidogenic enzymes in cultured rat zona glomerulosa cells.
Herpes Zoster
Potassium raises cytochrome P-45011 beta mRNA level in zona glomerulosa of rat adrenals.
Herpes Zoster
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
Herpes Zoster
Sympathoadrenal regulation of adrenal androstenedione release.
Herpes Zoster
Transcriptional activation of adrenocortical steroidogenic genes by high potassium or low sodium intake.
Hirsutism
Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism.
Hirsutism
Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women.
Hyperaldosteronism
A Dispensable Role for P450(scc) in the Overproduction of Aldosterone in Aldosterone-Producing Adenoma and Idiopathic Hyperaldosteronism in Patients with Primary Aldosteronism.
Hyperalgesia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Hyperandrogenism
Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism.
Hyperandrogenism
Current developments in the molecular genetics of the polycystic ovary syndrome.
Hyperandrogenism
Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS.
Hyperandrogenism
Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production.
Hyperandrogenism
Polycystic ovary syndrome: evidence for a primary disorder of ovarian steroidogenesis.
Hyperandrogenism
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS.
Hyperandrogenism
Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism.
Hyperandrogenism
Unusual Virilization in Girls with Juvenile Granulosa Cell Tumors of the Ovary Is Related to Intratumoral Aromatase Deficiency.
Hyperandrogenism
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]
Hypercalcemia
Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.
Hypercalcemia
Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/?-Catenin Pathways.
Hyperpigmentation
A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.
Hypertension
The combined impact of 12 common variants on hypertension in Japanese men, considering GWAS results.
Hypogonadism
S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells.
Hypospadias
A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.
Hypospadias
A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.
Hypospadias
Dysregulated expression of androgen metabolism genes and genetic analysis in hypospadias.
Infections
Mouse Forkhead L2 (FOXL2) maintains repression of FSH-dependent genes in the granulosa cell.
Insulin Resistance
Unacylated ghrelin stimulates steroidogenesis in lean rats and reverses reproductive dysfunction in high fat diet-fed rats.
Ischemic Stroke
CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study.
Keratoconus
Familial keratoconus with cataract: linkage to the long arm of chromosome 15 and exclusion of candidate genes.
Leiomyoma
[Effects of metformin on the expression of estrogen synthetase and ER mRNA in uterine leiomyoma tissues].
Lordosis
Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus.
Lung Diseases
Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease.
Lymphoma, B-Cell
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Malnutrition
Maternal Undernutrition Programs Offspring Adrenal Expression of Steroidogenic Enzymes.
Mania
Association of DNA Methylation with Acute Mania and Inflammatory Markers.
Melanoma
Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma.
Melanoma
Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.
Melanoma, Experimental
Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma.
Nasal Polyps
The expression of 11?-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp.
Neoplasm Metastasis
Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis.
Neoplasm Metastasis
Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma.
Neoplasms
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells.
Neoplasms
3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1.
Neoplasms
Adrenocortical cytochrome P-450 responsible for cholesterol side chain cleavage (P-450scc) is phosphorylated by the calcium-activated, phospholipid-sensitive protein kinase (protein kinase C).
Neoplasms
Alteration of testicular regulatory and functional molecules following long-time exposure to 900 MHz RFW emitted from BTS.
Neoplasms
Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage.
Neoplasms
Association between the CYP11 family and six cancer types.
Neoplasms
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Neoplasms
Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.
Neoplasms
Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma.
Neoplasms
Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice.
Neoplasms
DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence.
Neoplasms
Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic Acute Regulatory (StAR) protein.
Neoplasms
Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.
Neoplasms
Expression of adrenocorticotrophic hormone receptor mRNA in human adrenocortical neoplasms: correlation with P450scc expression.
Neoplasms
Features of the fetal gonad in androgen synthesis in the postpubertal testis are preserved in complete androgen insensitivity syndrome due to a novel genetic splice site donor variant in androgen receptor gene intron 1.
Neoplasms
Follicle-stimulating hormone-regulated Sertoli cell proteins SCc1 and SCc2 are phosphorylated and mitochondrially associated.
Neoplasms
Genipin improves reproductive health problems caused by circadian disruption in male mice.
Neoplasms
Glucocorticoid and cyclic adenosine 3'5'-monophosphate-mediated induction of cholesterol side-chain cleavage cytochrome P450 (P450scc) in MA-10 tumor Leydig cells. Increases in mRNA are cycloheximide sensitive.
Neoplasms
Gonadectomy-related adrenocortical tumors in ferrets demonstrate increased expression of androgen and estrogen synthesizing enzymes together with high inhibin expression.
Neoplasms
Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 alpha-hydroxylase/C17-20 lyase in Leydig cells.
Neoplasms
Hydroxylation of CYP11A1-derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1.
Neoplasms
Inhibin and activin differentially regulate androgen production and 17 alpha-hydroxylase expression in human ovarian thecal-like tumor cells.
Neoplasms
Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.
Neoplasms
Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells.
Neoplasms
Leydig cell tumor of the testis: analysis of testosterone production and secretion by three-dimensional histoculture.
Neoplasms
Malignant Adrenal Rest Tumor of the Retroperitoneum Producing Adrenocortical Steroids.
Neoplasms
Molecular characterization of a Leydig cell tumor presenting as congenital adrenal hyperplasia.
Neoplasms
Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression.
Neoplasms
Rainbow trout ovarian cholesterol side-chain cleavage cytochrome P450 (P450scc). cDNA cloning and mRNA expression during oogenesis.
Neoplasms
Recombinant murine tumor necrosis factor-alpha inhibits cholesterol side-chain cleavage cytochrome P450 and insulin-like growth factor-I gene expression in rat Leydig cells.
Neoplasms
Role of Constitutive STAR in Leydig Cells.
Neoplasms
Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation.
Neoplasms
StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies.
Neoplasms
Steroidogenesis in isolated cells and mitochondria of rat Snell adrenocortical carcinoma 494.
Neoplasms
Steroidogenic acute regulatory protein mRNA expression in adrenal tumours.
Neoplasms
Stimulation of cholesterol side-chain cleavage enzyme activity by cAMP and hCG in MA-10 Leydig tumor cells.
Neoplasms
Structures of regulatory regions in the human cytochrome P-450scc (desmolase) gene.
Neoplasms
The effect of insulin and insulin-like growth factors on the expression of steroidogenic enzymes in a human ovarian thecal-like tumor cell model.
Neoplasms
The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model.
Neoplasms
The effects of taxol, a microtubule-stabilizing drug, on steroidogenic cells.
Neoplasms
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.
Neoplasms
The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.
Neoplasms
The role of JUN in the regulation of PRKCC-mediated STAR expression and steroidogenesis in mouse Leydig cells.
Neoplasms
The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
Neoplasms
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
Neoplasms
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Neoplasms
Unusual Virilization in Girls with Juvenile Granulosa Cell Tumors of the Ovary Is Related to Intratumoral Aromatase Deficiency.
Neoplasms
[Effect of fluoride on the expression of StAR mRNA and P450scc mRNA in the testosterone synthesis of mouse Leydig tumor cells].
Nephrosis
Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome.
Nephrotic Syndrome
Impaired testicular cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory (StAR) protein expression in rats with nephrotic syndrome.
Neuralgia
Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks.
Neuralgia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Neuroblastoma
Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism.
Obesity
Prepubertal onset of obesity negatively impacts on testicular steroidogenesis in rats.
Obesity
Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells.
Optic Atrophy
Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones.
Optic Atrophy, Autosomal Dominant
Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones.
Ovarian Hyperstimulation Syndrome
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
Ovarian Hyperstimulation Syndrome
No Association Between the Microsatellite Polymorphism (TTTTA)( n ) in the Promoter of the CYP11A Gene and Ovarian Hyperstimulation Syndrome.
Perinatal Death
Mutation of Mouse Cyp11a1 Promoter Caused Tissue-Specific Reduction of Gene Expression and Blunted Stress Response without Affecting Reproduction.
Peripheral Nerve Injuries
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Peripheral Nervous System Diseases
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Pituitary Neoplasms
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
Placental Insufficiency
Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization.
Polycystic Ovary Syndrome
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India.
Polycystic Ovary Syndrome
Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women.
Polycystic Ovary Syndrome
Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism.
Polycystic Ovary Syndrome
Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
Polycystic Ovary Syndrome
CYP11A1 and CYP17 promoter polymorphisms associate with hyperandrogenemia in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone.
Polycystic Ovary Syndrome
Linum usitatissimum seeds oil down-regulates mRNA expression for the steroidogenic acute regulatory protein and Cyp11A1 genes, ameliorating letrezole-induced polycystic ovarian syndrome in a rat model.
Polycystic Ovary Syndrome
Microsatellite polymorphism of steroid hormone synthesis gene CYP11A1 is associated with advanced prostate cancer.
Polycystic Ovary Syndrome
Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome.
Polycystic Ovary Syndrome
Polymorphisms of pentanucleotide repeats (tttta)n in the promoter of CYP11A1 and their relationships to polycystic ovary syndrome (PCOS) risk: a meta-analysis.
Polycystic Ovary Syndrome
Population-based case-control study of CYP11A gene polymorphism and breast cancer risk.
Polycystic Ovary Syndrome
[Microsatellite polymorphism of (tttta) n in the promoter of CYP11a gene in Chinese women with polycystic ovary syndrome.]
Polycystic Ovary Syndrome
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]
Polyendocrinopathies, Autoimmune
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage.
Polyendocrinopathies, Autoimmune
Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED.
Pre-Eclampsia
A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.
Pre-Eclampsia
Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients.
Pre-Eclampsia
Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia.
Pre-Eclampsia
Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Pregnancy, Ectopic
Expression of 3beta-hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium.
Primary Ovarian Insufficiency
Autoantibodies in autoimmune polyendocrine syndrome type II.
Primary Ovarian Insufficiency
Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure.
Primary Ovarian Insufficiency
Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response.
Prostatic Hyperplasia
Microsatellite polymorphism of steroid hormone synthesis gene CYP11A1 is associated with advanced prostate cancer.
Prostatic Neoplasms
Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol.
Prostatic Neoplasms
Microsatellite polymorphism of steroid hormone synthesis gene CYP11A1 is associated with advanced prostate cancer.
Prostatic Neoplasms
Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.
Prostatic Neoplasms
Nuclear receptor ERR? contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis.
Prostatic Neoplasms
The presence of the CYP11A1 (TTTTA)6 allele increases the risk of biochemical relapse in organ confined and low-grade prostate cancer.
Seizures
Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy.
Seizures
Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period.
Seizures
Neurosteroids And Epileptogenesis.
Sleep Deprivation
Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation.
Smith-Lemli-Opitz Syndrome
Novel activities of CYP11A1 and their potential physiological significance.
Starvation
Progesterone production requires activation of caspase-3 in preovulatory granulosa cells in a serum starvation model.
Status Epilepticus
Neurosteroids And Epileptogenesis.
Tics
Isolation and identification of ovarian theca-interstitial cells and granulose cells of immature female mice.
Tuberculosis
Superoxide dismutase activity in transgenic canola.
Vitamin D Deficiency
Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism.
Vitamin K Deficiency
Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats.
Whooping Cough
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
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1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
