Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Endocrine causes of hypertension.
11beta-hydroxysteroid dehydrogenase deficiency
Epidemiologic study of adrenal gland disorders in Japan.
11beta-hydroxysteroid dehydrogenase deficiency
Steroid metabolism in metabolic syndrome X.
17alpha-hydroxyprogesterone deacetylase deficiency
Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Congenital adrenal hyperplasia in pregnancy.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Congenital adrenal hyperplasia.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Hyperandrogenism in female adolescents.
3beta-hydroxy-delta5-steroid dehydrogenase deficiency
Comprehensive genotyping of Turkish women with hirsutism.
46, XX Disorders of Sex Development
[A case of female pseudohermaphroditism caused by adrenal deficiency in 21-hydroxylase and 11-hydroxylase.]
Acidosis
[The human genome--chromosome 8]
Acidosis, Renal Tubular
[The human genome--chromosome 8]
Acne Vulgaris
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
Acne Vulgaris
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
Acne Vulgaris
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
Acromegaly
CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
Addison Disease
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Addison Disease
Epidemiologic study of adrenal gland disorders in Japan.
Addison Disease
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Addison Disease
[Should etomidate still be used?]
Adenocarcinoma
Down-regulation of D2 dopamine receptor and increased protein kinase Cmu phosphorylation in aldosterone-producing adenoma play roles in aldosterone overproduction.
Adenoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Adenoma
A patient with preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and contralateral adenoma.
Adenoma
A role for the NGFI-B family in adrenal zonation and adrenocortical disease.
Adenoma
Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).
Adenoma
ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma.
Adenoma
ACTH-independent macronodular adrenocortical hyperplasia: immunohistochemical and in situ hybridization studies of steroidogenic enzymes.
Adenoma
Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism.
Adenoma
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Adenoma
Adrenocortical zonation in humans under normal and pathological conditions.
Adenoma
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Adenoma
Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor.
Adenoma
Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.
Adenoma
Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.
Adenoma
Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.
Adenoma
Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.
Adenoma
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
Adenoma
Characterization of adrenal autonomy in Cushing's syndrome: a comparison between in vivo and in vitro responsiveness of the adrenal gland.
Adenoma
Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma.
Adenoma
Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome.
Adenoma
Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.
Adenoma
Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism.
Adenoma
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adenoma
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
Adenoma
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Adenoma
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Adenoma
Editorial Comment from Dr Fang to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Adenoma
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Adenoma
Editorial Comment from Dr Ishidoya to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Adenoma
Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas.
Adenoma
Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.
Adenoma
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma.
Adenoma
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
Adenoma
Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.
Adenoma
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Adenoma
Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism.
Adenoma
Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia.
Adenoma
Genetic and Histopathologic Inter-Tumor Heterogeneity in Primary Aldosteronism.
Adenoma
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.
Adenoma
Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.
Adenoma
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Adenoma
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Adenoma
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Adenoma
Hyperaldosteronism in pregnancy.
Adenoma
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.
Adenoma
Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas.
Adenoma
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Adenoma
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Adenoma
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Adenoma
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.
Adenoma
Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism.
Adenoma
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
Adenoma
Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.
Adenoma
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Adenoma
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
Adenoma
Mast Cell Hyperplasia is Associated with Aldosterone Hypersecretion in a subset of Aldosterone-Producing Adenomas.
Adenoma
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma.
Adenoma
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Adenoma
Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas.
Adenoma
New aspects on primary aldosteronism.
Adenoma
Normoaldosteronemic aldosterone-producing adenoma: immunochemical characterization and diagnostic implications.
Adenoma
Nuclear imaging in the diagnosis of primary aldosteronism.
Adenoma
Partial Adrenalectomy Carries a Considerable Risk of Incomplete Cure in Primary Aldosteronism.
Adenoma
Pathology of Aldosterone Biosynthesis and its Action.
Adenoma
Pathophysiological roles of the adrenal renin-angiotensin system in patients with primary aldosteronism.
Adenoma
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Adenoma
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Adenoma
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Adenoma
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Adenoma
Presence of Subclinical Hypercortisolism in Clinical Aldosterone-Producing Adenomas Predicts Lower Clinical Success.
Adenoma
Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing's syndrome: A case report.
Adenoma
Primary Aldosteronism: KCNJ5 Mutations and Adrenocortical Cell Growth.
Adenoma
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Adenoma
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Adenoma
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Adenoma
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma.
Adenoma
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.
Adenoma
Steroid Profiling as an Additional Tool to Confirm One-Sided Hormone Overproduction in Primary Aldosteronism: A Case Report.
Adenoma
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Adenoma
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.
Adenoma
The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenomas.
Adenoma
The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.
Adenoma
Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
Adenoma
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
Adenoma
Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma.
Adenoma
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.
Adenoma
[Mineralocorticoid syndromes and hypertension]
Adrenal Cortex Neoplasms
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Adrenal Cortex Neoplasms
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.
Adrenal Hyperplasia, Congenital
11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis.
Adrenal Hyperplasia, Congenital
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
Adrenal Hyperplasia, Congenital
11-deoxycortisol in amniotic fluid: prenatal diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
Adrenal Hyperplasia, Congenital
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
Adrenal Hyperplasia, Congenital
46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical Features.
Adrenal Hyperplasia, Congenital
A 5-year-old boy with cryptorchidism and pubic hair: investigation and management of apparent male disorders of sex development in mid-childhood.
Adrenal Hyperplasia, Congenital
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
Adrenal Hyperplasia, Congenital
A case of congenital adrenal hyperplasia with concomitant abnormalities of steroid 21- and 11 beta-hydroxylase activities.
Adrenal Hyperplasia, Congenital
A Chinese patient with 11?-hydroxylase deficiency due to novel compound heterozygous mutation in CYP11B1 gene: a case report.
Adrenal Hyperplasia, Congenital
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.
Adrenal Hyperplasia, Congenital
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
Adrenal Hyperplasia, Congenital
A novel missense mutation, GGC(Arg454) --> TGC(Cys), of CYP11B1 gene identified in a Chinese family with steroid 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
A Novel Mutation in the CYP11B1 Gene Causes Steroid 11?-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy.
Adrenal Hyperplasia, Congenital
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
Adrenal Hyperplasia, Congenital
Abnormalities of aldosterone synthesis and action in children.
Adrenal Hyperplasia, Congenital
Absence of steroid biosynthetic defects in heterozygote individuals for classic 11 beta-hydroxylase deficiency due to a R448H mutation in the CYP11B1 gene.
Adrenal Hyperplasia, Congenital
ACTH receptor blockade: a novel approach to treat congenital adrenal hyperplasia, or Cushing's disease.
Adrenal Hyperplasia, Congenital
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
Adrenal Hyperplasia, Congenital
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Adrenal Hyperplasia, Congenital
Aldosterone synthase deficiency and related disorders.
Adrenal Hyperplasia, Congenital
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Adrenal Hyperplasia, Congenital
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Androgen metabolism in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
Adrenal Hyperplasia, Congenital
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
Adrenal Hyperplasia, Congenital
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
Adrenal Hyperplasia, Congenital
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Adrenal Hyperplasia, Congenital
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Clinical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11).
Adrenal Hyperplasia, Congenital
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
Adrenal Hyperplasia, Congenital
Compound heterozygosity of a novel Q73X mutation and a known R141X mutation in CYP11B1 resulting in 11?-hydroxylase deficiency in a Chinese boy with congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia 11beta-hydroxylase deficiency: two cases managed with bilateral adrenalectomy.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency in Saudi Arabia: clinical and biochemical characteristics.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency in a Tunisian family.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: description of a new mutation, R384X.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency--insights from two novel CYP11B1 mutations (p.M92X, p.R453Q).
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency-Compound heterozygous mutations of a prevalent and two novel CYP11B1 mutations.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to 11-hydroxylase enzyme deficiency in three siblings. A brief report.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia family studies using the short ACTH test.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia in a Nigerian child with a novel compound heterozygote mutation in CYP11B1.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia secondary to 11beta-hydroxylase deficiency in a domestic cat.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia with 11-hydroxylase deficiency. A case report and contribution to diagnosis.
Adrenal Hyperplasia, Congenital
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Correction: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Adrenal Hyperplasia, Congenital
Cortisol production rate in children by gas chromatography/mass spectrometry using [1,2,3,4-13C]cortisol.
Adrenal Hyperplasia, Congenital
Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family.
Adrenal Hyperplasia, Congenital
CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Deoxycorticosterone, 11 beta-hydroxylase and the adrenal cortex.
Adrenal Hyperplasia, Congenital
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
Adrenal Hyperplasia, Congenital
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Adrenal Hyperplasia, Congenital
Diagnosis of congenital adrenal hyperplasia with 11-hydroxylase deficiency by determination of tetrahydro-11-desoxycortisol in urine.
Adrenal Hyperplasia, Congenital
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
Adrenal Hyperplasia, Congenital
Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect.
Adrenal Hyperplasia, Congenital
Disorders of steroid 11 beta-hydroxylase isozymes.
Adrenal Hyperplasia, Congenital
Disorders of steroid 17 alpha-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Adrenal Hyperplasia, Congenital
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Divergent gender identity in three siblings with 46XX karyotype and severely virilizing congenital adrenal hyperplasia caused by a novel CYP11B1 mutation.
Adrenal Hyperplasia, Congenital
Effect of hydrocortisone dose schedule on adrenal steroid secretion in congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Evidence for a new biologic pathway of androstenedione synthesis from 11-deoxycortisol.
Adrenal Hyperplasia, Congenital
Evidence for endocrinological abnormalities in heterozygotes for adrenal 11 beta-hydroxylase deficiency of a family with the R448H mutation in the CYP11B1 gene.
Adrenal Hyperplasia, Congenital
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
Adrenal Hyperplasia, Congenital
Familial pericentric inversion chromosome 3 and R448C mutation of CYP11B1 gene in Turkish kindred with 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11{beta}-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Gender identity in congenital adrenal hyperplasia secondary to 11-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Glucocorticoid treatment of girls with congenital adrenal hyperplasia: effects on height, sexual maturation, and fertility.
Adrenal Hyperplasia, Congenital
Growth and pubertal development in patients with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Adrenal Hyperplasia, Congenital
Gynaecomastia in two prepubertal boys with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
High frequency of congenital adrenal hyperplasia (classic 11 beta-hydroxylase deficiency) among Jews from Morocco.
Adrenal Hyperplasia, Congenital
HLA and congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Hormonal studies in obligate heterozygotes and siblings of patients with 11 beta-hydroxylase deficiency congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Hyperplasia of adrenal rest tissue causing a retroperitoneal mass in a child with 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Inherited forms of mineralocorticoid hypertension.
Adrenal Hyperplasia, Congenital
Isosexual precocity: the clinical and etiologic profile.
Adrenal Hyperplasia, Congenital
Kinetics and metabolism of 11-deoxycortisol in a patient with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Adrenal Hyperplasia, Congenital
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Missense mutation in CYP11B1 (CGA[Arg-384]-->GGA[Gly]) causes steroid 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.
Adrenal Hyperplasia, Congenital
Molecular genetics of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Mutations in CYP11B1 and congenital adrenal hyperplasia in Moroccan Jews.
Adrenal Hyperplasia, Congenital
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Adrenal Hyperplasia, Congenital
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Adrenal Hyperplasia, Congenital
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
Adrenal Hyperplasia, Congenital
New aspects of mineralocorticoid hypertension.
Adrenal Hyperplasia, Congenital
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
No linkage between HLA and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Nonclassic 11 beta-hydroxylase deficiency: report of two patients and review.
Adrenal Hyperplasia, Congenital
Novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Novel homozygous p.Y395X mutation in the CYP11B1 gene found in a Vietnamese patient with 11?-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Novel missense mutations, GCC [Ala306]- > GTC [Val] and ACG [Thr318]- > CCG [Pro], in the CYP11B1 gene cause steroid 11beta-hydroxylase deficiency in the Chinese.
Adrenal Hyperplasia, Congenital
Novel mutations in CYP11B1 gene leading to 11 beta-hydroxylase deficiency in Brazilian patients.
Adrenal Hyperplasia, Congenital
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
Adrenal Hyperplasia, Congenital
Over 50 Years of Progress in the Treatment of the Hypertensive Form of Congenital Adrenal Hyperplasia due to Steroid 11-Beta-Hydroxylase Deficiency. Commentary on Simm PJ and Zacharin MR: Successful Pregnancy in a Patient with severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene (Horm Res 2007;68:294-297).
Adrenal Hyperplasia, Congenital
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
Adrenal Hyperplasia, Congenital
Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene.
Adrenal Hyperplasia, Congenital
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
Adrenal Hyperplasia, Congenital
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
Adrenal Hyperplasia, Congenital
Prenatal diagnosis of 11beta-hydroxylase deficiency congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Rapid diagnosis of congenital adrenal hyperplasia by high performance liquid chromatography.
Adrenal Hyperplasia, Congenital
Requirement of mineralocorticoid in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
Adrenal Hyperplasia, Congenital
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene.
Adrenal Hyperplasia, Congenital
Steroid 11 beta-hydroxylase deficiency and related disorders.
Adrenal Hyperplasia, Congenital
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
Adrenal Hyperplasia, Congenital
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Adrenal Hyperplasia, Congenital
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Steroids and hypertension.
Adrenal Hyperplasia, Congenital
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
Adrenal Hyperplasia, Congenital
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
Adrenal Hyperplasia, Congenital
The combination of a novel 2 bp deletion mutation and p.D63H in CYP11B1 cause congenital adrenal hyperplasia due to steroid 11?-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Three novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11Beta-hydroxylase deficiency in a moroccan population.
Adrenal Hyperplasia, Congenital
Two intronic variants of CYP11B1 and CYP17A1 disrupt mRNA splicing and cause congenital adrenal hyperplasia (CAH).
Adrenal Hyperplasia, Congenital
Two novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11? hydroxylase deficiency in a Tunisian family.
Adrenal Hyperplasia, Congenital
Two novel mutations in CYP11B1 and modeling the consequent alterations of the translated protein in classic congenital adrenal hyperplasia patients.
Adrenal Hyperplasia, Congenital
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia.
Adrenal Hyperplasia, Congenital
Uniparental disomy of chromosome 8 leading to homozygosity of a CYP11B1 mutation in a patient with congenital adrenal hyperplasia: Implication for a rare etiology of an autosomal recessive disorder.
Adrenal Hyperplasia, Congenital
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Adrenal Hyperplasia, Congenital
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
Adrenal Hyperplasia, Congenital
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
Adrenal Hyperplasia, Congenital
[11beta-hydroxylase deficiency]
Adrenal Hyperplasia, Congenital
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
Adrenal Hyperplasia, Congenital
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Adrenal Hyperplasia, Congenital
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Adrenal Hyperplasia, Congenital
[Congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency. A case report]
Adrenal Hyperplasia, Congenital
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency - different HLA genotypes in 2 brothers]
Adrenal Hyperplasia, Congenital
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
Adrenal Hyperplasia, Congenital
[Congenital adrenal hyperplasia. Presentation of a case and review of the literature]
Adrenal Hyperplasia, Congenital
[Familial congenital adrenal hyperplasia caused by 11 beta-hydroxylase. Failure of prevention of sexual ambiguity and prenatal diagnosis]
Adrenal Hyperplasia, Congenital
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
Adrenal Hyperplasia, Congenital
[Rare forms of female pseudohermaphroditism: when to investigate?]
Adrenal Hyperplasia, Congenital
[Severe form of congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency in a 3-year old boy]
Adrenal Hyperplasia, Congenital
[Variations of production rate of cortisol, corticosterone, aldosterone and desoxycorticosterone in 4 cases of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency]
Adrenal Insufficiency
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Adrenal Insufficiency
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Adrenal Rest Tumor
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
Adrenal Rest Tumor
Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours.
Adrenal Rest Tumor
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Adrenal Rest Tumor
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Adrenal Rest Tumor
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Adrenal Rest Tumor
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Adrenocortical Adenoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Adrenocortical Adenoma
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Adrenocortical Adenoma
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
Adrenocortical Adenoma
Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance.
Adrenocortical Adenoma
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Adrenocortical Adenoma
Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary aldosteronism: an insight into the underlying mechanism.
Adrenocortical Adenoma
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.
Adrenocortical Adenoma
Imaging of adrenal masses with emphasis on adrenocortical tumors.
Adrenocortical Adenoma
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
Adrenocortical Adenoma
MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.
Adrenocortical Adenoma
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Adrenocortical Adenoma
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.
Adrenocortical Carcinoma
AT1AA (Angiotensin II Type-1 Receptor Autoantibodies): Cause or Consequence of Human Primary Aldosteronism?
Adrenocortical Carcinoma
Autocrine-paracrine role of endothelin-1 in the regulation of aldosterone synthase expression and intracellular Ca2+ in human adrenocortical carcinoma NCI-H295 cells.
Adrenocortical Carcinoma
Autocrine-Paracrine Role of Endothelin-1 in the Regulation of Aldosterone Synthase Expression and Intracellular Ca2+ in Human Adrenocortical Carcinoma NCI-H295 Cells.
Adrenocortical Carcinoma
Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
Adrenocortical Carcinoma
CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.
Adrenocortical Carcinoma
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Adrenocortical Carcinoma
Effects of Adipocyte-derived Factors on the Adrenal Cortex.
Adrenocortical Carcinoma
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Adrenocortical Carcinoma
Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.
Adrenocortical Carcinoma
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Adrenocortical Carcinoma
Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways.
Adrenocortical Carcinoma
Visinin-Like 1 Is Upregulated in Aldosterone-Producing Adenomas With KCNJ5 Mutations and Protects From Calcium-Induced Apoptosis.
Adrenocortical Hyperfunction
Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-? hydroxysteroid dehydrogenase type 1.
Adrenocortical Hyperfunction
[Study of a case of cogenital hypercorticism due to disorder of 11 beta-hydroxylase. Identification of compound "S", desoxycorticosterone and compound "B".]
Adrenogenital Syndrome
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Adrenogenital Syndrome
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
Adrenogenital Syndrome
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
Adrenogenital Syndrome
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
Adrenogenital Syndrome
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
Adrenogenital Syndrome
[Diagnosis of the adrenogenital syndrome caused by 11beta-hydroxylase deficiency using gas chromatographic-mass spectrometric analysis of the urinary steroid profile]
Adrenogenital Syndrome
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
Adrenogenital Syndrome
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
Albuminuria
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
Alkalosis
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Alopecia
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
Alopecia
Urinary steroids in women with androgenic alopecia.
Antley-Bixler Syndrome Phenotype
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
aromatase deficiency
46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical Features.
Atherosclerosis
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice.
Atherosclerosis
Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging.
Atrial Fibrillation
A comprehensive meta-analysis on relationship between CYP11B2 rs1799998 polymorphism and atrial fibrillation.
Atrial Fibrillation
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Atrial Fibrillation
Association between aldosterone synthase (CYP11B2) -344C/T polymorphism and atrial fibrillation among Han and Kazak residents of the Xinjiang region.
Atrial Fibrillation
Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
Atrial Fibrillation
Association of angiotensin-converting enzyme gene I/D and CYP11B2 gene -344T/C polymorphisms with lone atrial fibrillation and its recurrence after catheter ablation.
Atrial Fibrillation
Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population.
Atrial Fibrillation
CYP11B2 T-344C gene polymorphism and atrial fibrillation: a meta-analysis of 2,758 subjects.
Atrial Fibrillation
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease.
Atrial Fibrillation
Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.
Atrial Fibrillation
Mineralocorticoid receptor, CYP11B2 mRNA expression, and atrial matrix remodelling in patients with atrial fibrillation.
Atrial Fibrillation
MiR-138-5p is downregulated in patients with atrial fibrillation and reverses cardiac fibrotic remodeling via repressing CYP11B2.
Atrial Fibrillation
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Atrial Fibrillation
Relationship between CYP11B2-344T>C polymorphsim and atrial fibrillation: A meta-analysis.
Atrial Fibrillation
[Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation]
Atrial Fibrillation
[The relation between angiotensin II receptors 1 and 2, and CYP11B2 and atrial structural remodeling in patients with atrial fibrillation]
Brain Ischemia
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
Brain Ischemia
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
Breast Neoplasms
A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
Breast Neoplasms
Role of the renin-angiotensin-aldosterone system and the glutathione S-transferase Mu, Pi and Theta gene polymorphisms in cardiotoxicity after anthracycline chemotherapy for breast carcinoma.
Breast Neoplasms
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Breast Neoplasms
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
Bronchial Hyperreactivity
Pharmacological study of bacterial lipopolysaccharide-induced airway hyperresponsiveness in guinea-pigs.
Carcinogenesis
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
Carcinoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Carcinoma
Development of a high-throughput assay for aldosterone synthase inhibitors using high-performance liquid chromatography-tandem mass spectrometry.
Carcinoma
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Carcinoma
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Carcinoma
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Carcinoma, Hepatocellular
Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.
Cardiomegaly
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
Cardiomegaly
Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2.
Cardiomegaly
Human aldosterone synthase gene polymorphism promotes miRNA binding and regulates gene expression.
Cardiomegaly
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.
Cardiomegaly
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
Cardiomyopathies
A Novel Mutation in the CYP11B1 Gene Causes Steroid 11?-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy.
Cardiomyopathy, Dilated
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Association between aldosterone synthase (CYP11B2) gene polymorphism and left ventricular volume in patients with dilated cardiomyopathy.
Cardiomyopathy, Dilated
Impact of repeated intravenous bone marrow mesenchymal stem cells infusion on myocardial collagen network remodeling in a rat model of doxorubicin-induced dilated cardiomyopathy.
Cardiomyopathy, Dilated
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
Cardiomyopathy, Dilated
[Study on association between aldosterone synthase gene polymorphism and the left ventricular structure and function of patients with dilated cardiomyopathy in China]
Cardiomyopathy, Hypertrophic
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
Cardiomyopathy, Hypertrophic
[Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy]
Cardiotoxicity
Role of the renin-angiotensin-aldosterone system and the glutathione S-transferase Mu, Pi and Theta gene polymorphisms in cardiotoxicity after anthracycline chemotherapy for breast carcinoma.
Cardiovascular Diseases
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
Cardiovascular Diseases
3-Pyridyl substituted aliphatic cycles as CYP11B2 inhibitors: aromaticity abolishment of the core significantly increased selectivity over CYP1A2.
Cardiovascular Diseases
Aldosterone synthase inhibitors for cardiovascular diseases: A comprehensive review of preclinical, clinical and in silico data.
Cardiovascular Diseases
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Cardiovascular Diseases
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Cardiovascular Diseases
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Cardiovascular Diseases
CYP11B2 gene polymorphism among coronary heart disease patients and blood donors in Malaysia.
Cardiovascular Diseases
Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms.
Cardiovascular Diseases
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
Cardiovascular Diseases
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
Cardiovascular Diseases
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Cardiovascular Diseases
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Cardiovascular Diseases
[The role of the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) in cardiovascular diseases]
Carotid Artery Diseases
Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging.
Catalepsy
Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice.
Cholera
Expression of 11 beta-hydroxylase and 21-hydroxylase in long-term cultures of bovine adrenocortical cells requires extracellular matrix factors.
Cholera
Interaction of phorbol ester and adrenocorticotropin in the regulation of steroidogenic P450 genes in human fetal and adult adrenal cell cultures.
Cholera
Regulation of 11 beta- and 17 alpha-hydroxylases in cultured bovine adrenocortical cells: 3', 5'-cyclic adenosine monophosphate, insulin-like growth factor-I, and activators of protein kinase C.
Coinfection
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
Colitis
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis.
Colitis
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Coronary Artery Disease
Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels.
Coronary Artery Disease
Association between the CYP11B2 gene -344T>C polymorphism and coronary artery disease: a meta-analysis.
Coronary Artery Disease
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Coronary Artery Disease
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
Coronary Disease
Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction.
Coronary Disease
CYP11B2 gene polymorphism among coronary heart disease patients and blood donors in Malaysia.
Coronary Disease
Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease.
corticosterone 18-monooxygenase deficiency
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
corticosterone 18-monooxygenase deficiency
Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
Cryptorchidism
Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization.
Cryptorchidism
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Cushing Syndrome
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Cushing Syndrome
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
Cushing Syndrome
Adrenocortical zonation in humans under normal and pathological conditions.
Cushing Syndrome
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia.
Cushing Syndrome
Assessment of in vitro effects of metyrapone on Leydig cell steroidogenesis.
Cushing Syndrome
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Cushing Syndrome
Characterization of adrenal autonomy in Cushing's syndrome: a comparison between in vivo and in vitro responsiveness of the adrenal gland.
Cushing Syndrome
Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome.
Cushing Syndrome
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (Pyridylmethyl)pyridine type.
Cushing Syndrome
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Cushing Syndrome
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Cushing Syndrome
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Cushing Syndrome
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Cushing Syndrome
Endocrine causes of hypertension.
Cushing Syndrome
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Cushing Syndrome
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
Cushing Syndrome
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Cushing Syndrome
Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.
Cushing Syndrome
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Cushing Syndrome
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
Cushing Syndrome
New aspects on primary aldosteronism.
Cushing Syndrome
Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing's Syndrome.
Cushing Syndrome
Optimization of the First Selective Steroid-11?-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Cushing Syndrome
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Cushing Syndrome
Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate.
Cushing Syndrome
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Cushing Syndrome
Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).
Cushing Syndrome
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors.
Cushing Syndrome
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
Cushing Syndrome
[Endocrine and neurogenic hypertension in childhood]
Cushing Syndrome
[Medical treatment for Cushing's syndrome]
Cysts
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
Cysts
Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme.
Cysts
Thyroid cysts: a new extra-adrenal site of aldosterone synthase expression and increased aldosterone content.
Dehydration
Aldosterone synthase deficiency type II with hypospadias.
Dehydration
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Dehydration
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
Dementia
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Diabetes Mellitus
Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
Diabetes Mellitus
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Diabetes Mellitus
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Diabetes Mellitus
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
Diabetes Mellitus
Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.
Diabetes Mellitus
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
Diabetes Mellitus
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
Diabetes Mellitus
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
Diabetes Mellitus
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
Diabetes Mellitus
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
Diabetes Mellitus
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Diabetes Mellitus
Retraction notice.
Diabetes Mellitus, Type 2
Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.
Diabetes Mellitus, Type 2
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Diabetes Mellitus, Type 2
Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.
Diabetic Nephropathies
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients.
Diabetic Nephropathies
Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy.
Diabetic Nephropathies
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy.
Diabetic Nephropathies
Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis.
Diabetic Nephropathies
Mitigating risk of aldosterone in diabetic kidney disease.
Diabetic Nephropathies
Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients.
Diabetic Nephropathies
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
Diabetic Nephropathies
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
Diabetic Nephropathies
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
Diabetic Nephropathies
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
Diabetic Nephropathies
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Diabetic Nephropathies
Retraction notice.
Diabetic Nephropathies
Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats.
Disorders of Sex Development
A Greek girl with 11?-hydroxylase deficiency due to compound heterozygosity for two novel mutations in CYP11B1 gene.
Disorders of Sex Development
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Disorders of Sex Development
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
Disorders of Sex Development
Inborn errors of adrenal steroidogenesis.
Disorders of Sex Development
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
Disorders of Sex Development
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
Drug-Related Side Effects and Adverse Reactions
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Dwarfism
The use of an adrenocortical 11-beta-hydroxylase inhibitor, (methopyrone) in the differential diagnosis of dwarfism.
Dwarfism
[Studies on the pituitary ACTH secretory capacity in children using 11-beta-hydroxylase inhibitor (Metopirone). 2. Diagnostic value in pituitary dwarfism in children]
Dwarfism
[The use of an adrenal 11-beta-hydroxylase inhibitor (Metopirone) in the diagnosis of nanism.]
Dwarfism, Pituitary
[Studies on the pituitary ACTH secretory capacity in children using 11-beta-hydroxylase inhibitor (Metopirone). 2. Diagnostic value in pituitary dwarfism in children]
Dyslipidemias
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
Eclampsia
Correlations of CYP11B2 gene polymorphisms with eclampsia.
Eclampsia
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Endocrine System Diseases
Endocrine causes of hypertension.
Endocrine System Diseases
[Endocrine and neurogenic hypertension in childhood]
Essential Hypertension
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
Essential Hypertension
A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to renin ratio in selected hypertensive patients.
Essential Hypertension
A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension.
Essential Hypertension
A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
Essential Hypertension
A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han.
Essential Hypertension
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
Essential Hypertension
Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2.
Essential Hypertension
Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy.
Essential Hypertension
Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-? hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India.
Essential Hypertension
An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects.
Essential Hypertension
Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension.
Essential Hypertension
Association between Aldosterone Synthase CYP11B2 Polymorphism and Essential Hypertension in Chinese: A Meta-Analysis.
Essential Hypertension
Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals.
Essential Hypertension
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Essential Hypertension
Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population.
Essential Hypertension
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Essential Hypertension
Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis.
Essential Hypertension
Association of the -344T/C aldosterone synthase gene variant with essential hypertension.
Essential Hypertension
Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population.
Essential Hypertension
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
Essential Hypertension
Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.
Essential Hypertension
Association of the Human CYP11B2 Gene and Essential Hypertension in Southwest Han Chinese Population: A Haplotype-Based Case-Control Study.
Essential Hypertension
Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
Essential Hypertension
Associations between human aldosterone synthase CYP11B2 (-344T/C) gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension.
Essential Hypertension
Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: a case-control study.
Essential Hypertension
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Essential Hypertension
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
Essential Hypertension
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Essential Hypertension
CYP11B2 gene polymorphism and essential hypertension among Tibetan, Dongxiang and Han populations from northwest of China.
Essential Hypertension
CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.
Essential Hypertension
Dissecting hypertension: the role of the 'new genetics'.
Essential Hypertension
Effects of the C-344T aldosterone synthase gene variant on preclinical vascular alterations in essential hypertension.
Essential Hypertension
Genetic and functional analyses of aldosterone synthase gene C-344T polymorphism with essential hypertension.
Essential Hypertension
Genetic determinants of human hypertension.
Essential Hypertension
Genetic determination of plasma aldosterone levels in essential hypertension.
Essential Hypertension
Genetically determined enlargement of carotid body evaluated using computed angiotomography.
Essential Hypertension
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.
Essential Hypertension
Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension.
Essential Hypertension
Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.
Essential Hypertension
Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.
Essential Hypertension
Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population.
Essential Hypertension
Interaction of ACE and CYP11B2 Genes on Blood Pressure Response to Hydrochlorothiazide in Han Chinese Hypertensive Patients.
Essential Hypertension
Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension.
Essential Hypertension
Intron-2 conversion polymorphism of the aldosterone synthase gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.
Essential Hypertension
Investigation of major genetic polymorphisms in the Renin-Angiotensin-aldosterone system in subjects with young-onset hypertension selected by a targeted-screening system at university.
Essential Hypertension
Lack of association of CYP11B2-344C/T polymorphism with essential hypertension: a meta-analysis.
Essential Hypertension
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Essential Hypertension
Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.
Essential Hypertension
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.
Essential Hypertension
Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension.
Essential Hypertension
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol.
Essential Hypertension
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Essential Hypertension
Steroid metabolism in metabolic syndrome X.
Essential Hypertension
Structural analysis and evaluation of the aldosterone synthase gene in hypertension.
Essential Hypertension
Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension.
Essential Hypertension
The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese.
Essential Hypertension
The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.
Essential Hypertension
[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study]
Essential Hypertension
[Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with essential hypertension in Mongolian nationality].
Essential Hypertension
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
Essential Hypertension
[Association of aldosterone synthase gene -344T/C polymorphism with plasma aldosterone and angiotensin II concentration in hypertensive patients]
Essential Hypertension
[Association of polymorphisms in ACE and CYP11B2 genes with antihypertensive effects of hydrochlorothiazide]
Essential Hypertension
[Association of the -344T/C polymorphism of the aldosterone synthase gene with essential hypertension]
Essential Hypertension
[Association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B2 with essential hypertension in Xinjiang Kazakh isolated group.]
Essential Hypertension
[Correlativity between the polymorphisms of aldosterone synthase gene, Hind III restriction site on Y chromosome and essential hypertension]
Essential Hypertension
[Effect of CYP11B2 gene -344T/C polymorphism on renin-angiotensin-aldosterone system activity and blood pressure response to hydrochlorothiazide].
Essential Hypertension
[Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]
Essential Hypertension
[Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population]
Essential Hypertension
[Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population].
Essential Hypertension
[Relationship between aldosterone synthase gene (CYPJLB2) polymorphisms and essential hypertension in a northern Chinese Han population]
Essential Hypertension
[Single nucleotide polymorphisms of three candidate genes in essential hypertension]
Essential Hypertension
[Specifics of distribution of polymorphic markers of the renin-angiotensin-system genes, relation to ventricular hypertrophy in patients with essential hypertension of Uzbek nationality]
Essential Hypertension
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
Gastroenteritis
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Genetic Diseases, Inborn
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
Genetic Diseases, Inborn
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
Genetic Diseases, Inborn
Aldosterone synthase (CYP11B2) deficiency among Palestinian infants: Three novel variants and genetic heterogeneity.
Genetic Diseases, Inborn
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Genetic Diseases, Inborn
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
Genetic Diseases, Inborn
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Glioma
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
Glomerulonephritis
Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with the risk of primary chronic glomerulonephritis in the Polish population.
Glomerulonephritis, IGA
Expression of aldosterone synthase gene in IgA nephropathy (IgAN).
Glomerulonephritis, IGA
Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy.
Glomerulonephritis, IGA
Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy.
Glomerulonephritis, IGA
Impact of Aldosterone Synthase Gene C-344T Polymorphism on IgA Nephropathy.
Glomerulonephritis, IGA
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
Glomerulonephritis, IGA
Retracted: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy.
Glomerulonephritis, IGA
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
Glomerulonephritis, IGA
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
Glomerulonephritis, IGA
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
Glomerulonephritis, IGA
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Glomerulonephritis, IGA
RETRACTED: Role of renin-angiotensin-aldosterone system inhibitors in radiation nephropathy.
Glomerulonephritis, IGA
Retraction notice.
Glomerulosclerosis, Focal Segmental
Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis.
Gynecomastia
11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia.
Gynecomastia
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.
Gynecomastia
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency.
Gynecomastia
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Hearing Loss, Bilateral
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Hearing Loss, Sensorineural
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Heart Diseases
Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.
Heart Diseases
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease.
Heart Failure
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
Heart Failure
A novel aldosterone synthase inhibitor ameliorates mortality in pressure-overload mice with heart failure.
Heart Failure
A patent review of aldosterone synthase inhibitors (2014-present).
Heart Failure
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Heart Failure
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
Heart Failure
Aldosterone synthase inhibition in humans.
Heart Failure
Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial.
Heart Failure
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy.
Heart Failure
Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
Heart Failure
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Heart Failure
Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).
Heart Failure
Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
Heart Failure
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Heart Failure
Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis.
Heart Failure
Emerging role of pharmacogenomics in heart failure.
Heart Failure
Expression of aldosterone synthase gene in failing human heart: quantitative analysis using modified real-time polymerase chain reaction.
Heart Failure
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Heart Failure
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Heart Failure
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Heart Failure
Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level.
Heart Failure
Imidazopyridyl compounds as aldosterone synthase inhibitors.
Heart Failure
Novel therapies in acute and chronic heart failure.
Heart Failure
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Heart Failure
Pharmacophore Modeling and
Heart Failure
Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population.
Heart Failure
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Heart Failure
TaqMan real-time PCR quantification: conventional and modified methods.
Heart Failure
TaqMan Real-Time PCR Quantification: Conventional and Modified Methods.
Heart Failure
The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Heart Failure
Toward a broader understanding of aldosterone in congestive heart failure.
Heart Failure
Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.
Heart Failure, Systolic
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Heart Failure, Systolic
Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.
HELLP Syndrome
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Hemorrhagic Stroke
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
Herpes Simplex
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Herpes Simplex
Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
Herpes Zoster
'Treasure your exceptions': what we can learn from autosomal-dominant inherited forms of hypertension.
Herpes Zoster
11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension?
Herpes Zoster
11 beta-Hydroxylase gene expression in the rat adrenal cortex.
Herpes Zoster
11?-Hydoxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis.
Herpes Zoster
18-Ethynyl-deoxycorticosterone inhibition of steroid production is different in freshly isolated compared to cultured calf zona glomerulosa cells.
Herpes Zoster
19-Acetylenic-deoxycorticosterone inhibits 19-hydroxylase and 11 beta-hydroxylase activities in dispersed bovine zona fasciculata cells.
Herpes Zoster
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
Herpes Zoster
A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role.
Herpes Zoster
A role for steroid hormones in the variability of blood pressure determination.
Herpes Zoster
Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism.
Herpes Zoster
ACTH and PRL sensitivity of highly differentiated cell lines obtained by adrenocortical targeted oncogenesis.
Herpes Zoster
Acute and chronic regulation of aldosterone production.
Herpes Zoster
Adrenal cortex tissue homeostasis and zonation: A WNT perspective.
Herpes Zoster
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Herpes Zoster
Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.
Herpes Zoster
Adrenocortical zonation in humans under normal and pathological conditions.
Herpes Zoster
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Herpes Zoster
Adrenocorticotropic hormone stimulates CYP11B1 gene transcription through a mechanism involving AP-1 factors.
Herpes Zoster
Age-Related Autonomous Aldosteronism.
Herpes Zoster
Aldosterone biosynthesis in mitochondria of isolated zones of adrenal cortex.
Herpes Zoster
Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
Herpes Zoster
Aldosterone: the minority hormone of the adrenal cortex.
Herpes Zoster
Altered 11 beta-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism.
Herpes Zoster
Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.
Herpes Zoster
Angiotensin stimulates the expression of interferon-inducible genes in H295R cells.
Herpes Zoster
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.
Herpes Zoster
Baboon CYP11B1: the localization and catalytic activity in baboon adrenal tissue.
Herpes Zoster
Biphasic Time Course of the Changes in Aldosterone Biosynthesis Under High Salt Conditions in Dahl Salt-Sensitive Rats.
Herpes Zoster
Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism.
Herpes Zoster
Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases.
Herpes Zoster
Calcineurin Mediates The Angiotensin II-induced Aldosterone Synthesis in the Adrenal Glands by Upregulation of Transcription of The CYP11B2 Gene.
Herpes Zoster
Calcium regulates human CYP11B2 transcription.
Herpes Zoster
Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
Herpes Zoster
Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism.
Herpes Zoster
Changes in the glomerulosa cell phenotype during adrenal regeneration in rats.
Herpes Zoster
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Herpes Zoster
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.
Herpes Zoster
Chimeric CYP11B2/CYP11B1 causing 11?-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.
Herpes Zoster
Chronic angiotensin treatment stimulates the growth and the 11 beta-hydroxylase activity of rat zona fasciculata cells.
Herpes Zoster
Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC.
Herpes Zoster
Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells.
Herpes Zoster
Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes.
Herpes Zoster
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
Herpes Zoster
Corticosteroid synthesis in the central nervous system.
Herpes Zoster
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Herpes Zoster
Csk Regulates Blood Pressure by Controlling the Synthetic Pathways of Aldosterone.
Herpes Zoster
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
Herpes Zoster
Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.
Herpes Zoster
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
Herpes Zoster
Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase.
Herpes Zoster
Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
Herpes Zoster
Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes.
Herpes Zoster
Dietary potassium supplementation and sodium restriction stimulate aldosterone synthase but not 11 beta-hydroxylase P-450 messenger ribonucleic acid accumulation in rat adrenals and require angiotensin II production.
Herpes Zoster
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.
Herpes Zoster
Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion.
Herpes Zoster
Disordered CYP11B2 Expression in Primary Aldosteronism.
Herpes Zoster
Disorders of steroid 11beta-hydroxylase isozymes.
Herpes Zoster
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Herpes Zoster
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.
Herpes Zoster
Does aldosterone play a significant role for regulation of vascular tone?
Herpes Zoster
Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase.
Herpes Zoster
Effects of chloramphenicol on the long term trophic action of ACTH on rat adrenocortical cells: a combined stereological and enzymological study.
Herpes Zoster
Effects of long term stimulation of ACTH and angiotensin II-secretions on the rat adrenal cortex.
Herpes Zoster
Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.
Herpes Zoster
Gene conversion in the CYP11B2 gene encoding P450c11AS is associated with, but does not cause, the syndrome of corticosterone methyloxidase II deficiency.
Herpes Zoster
Genetic and Histopathologic Inter-Tumor Heterogeneity in Primary Aldosteronism.
Herpes Zoster
Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.
Herpes Zoster
Glucocorticoid remediable aldosteronism: a case report.
Herpes Zoster
Glucocorticoid-remediable aldosteronism.
Herpes Zoster
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Herpes Zoster
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Herpes Zoster
Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.
Herpes Zoster
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Herpes Zoster
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Herpes Zoster
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Herpes Zoster
Immunohistochemistry of the adrenal in primary aldosteronism.
Herpes Zoster
In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion.
Herpes Zoster
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
Herpes Zoster
In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal.
Herpes Zoster
Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.
Herpes Zoster
Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells.
Herpes Zoster
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
Herpes Zoster
Investigations on the effects of long-term administration of a methionine-enkephalin analogue on the adrenal zona fasciculata of rats treated with dexamethasone or dexamethasone and ACTH.
Herpes Zoster
Involvement of an AP-1 complex in zone-specific expression of the CYP11B1 gene in the rat adrenal cortex.
Herpes Zoster
Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex.
Herpes Zoster
Late steps of aldosterone biosynthesis: sheep are not rats.
Herpes Zoster
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
Herpes Zoster
Localization of the gene transcripts of 11 beta-hydroxylase and aldosterone synthase in the rat adrenal cortex by in situ hybridization.
Herpes Zoster
Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism.
Herpes Zoster
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
Herpes Zoster
New aspects on primary aldosteronism.
Herpes Zoster
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
Herpes Zoster
OS067. VEGF, a novel stimulator of aldosterone production.
Herpes Zoster
P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities.
Herpes Zoster
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
Herpes Zoster
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Herpes Zoster
Pathogenesis and treatment of primary aldosteronism.
Herpes Zoster
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Herpes Zoster
Potassium induces multiple steroidogenic enzymes in cultured rat zona glomerulosa cells.
Herpes Zoster
Pref-1, SF-1 and adrenocortical zonation.
Herpes Zoster
Primary Aldosteronism in the Elderly.
Herpes Zoster
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Herpes Zoster
Rat glomerulosa cells in primary culture and E. coli lipopolysaccharide action.
Herpes Zoster
Regulation of adrenal steroidogenesis during chronic stress.
Herpes Zoster
Regulation of aldosterone biosynthesis: the end of the road?
Herpes Zoster
Regulation of aldosterone in the 7-day-old rat.
Herpes Zoster
Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members.
Herpes Zoster
Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium.
Herpes Zoster
Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Herpes Zoster
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
Herpes Zoster
Role of rat adrenal antioxidant defense systems in the aldosterone turn-off phenomenon.
Herpes Zoster
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
Herpes Zoster
Separate induction of the two isozymes of cytochrome P-450(11) beta in rat adrenal zona glomerulosa cells.
Herpes Zoster
Sodium restriction increases aldosterone biosynthesis by increasing late pathway, but not early pathway, messenger ribonucleic acid levels and enzyme activity in normotensive rats.
Herpes Zoster
Stable expression of rat cytochrome P450 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in MA-10 cells.
Herpes Zoster
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Herpes Zoster
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Herpes Zoster
Structure of an ovine CYP11B1 gene.
Herpes Zoster
Studies of adrenal steroidogenic enzymes in guinea pigs.
Herpes Zoster
Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.
Herpes Zoster
TASK1 and TASK3 Potassium Channels: Determinants of Aldosterone Secretion and Adrenocortical Zonation.
Herpes Zoster
The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity.
Herpes Zoster
The Herbicide Atrazine Potentiates Angiotensin II-Induced Aldosterone Synthesis and Release From Adrenal Cells.
Herpes Zoster
The hybrid rat cytochrome P450 containing the first 5 exons of the CYP11B1 and last 4 exons from the CYP11B2 enzyme retains 11 beta-hydroxylase activity, but the alternative hybrid is inactive.
Herpes Zoster
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
Herpes Zoster
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
Herpes Zoster
The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.
Herpes Zoster
The regulation of aldosterone synthase expression.
Herpes Zoster
The use of high-pressure liquid chromatography in the simultaneous assay of 11beta-hydroxylase and 18-hydroxylase in zona fasciculata-reticularis tissue of the rat adrenal cortex.
Herpes Zoster
Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
Herpes Zoster
Two types of cytochrome P-450(11 beta) in rat adrenals: separate regulation of gene expression.
Herpes Zoster
Two-pore domain potassium channels in the adrenal cortex.
Herpes Zoster
Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
Herpes Zoster
Unique cases of unilateral hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective adrenal venous sampling.
Herpes Zoster
Urotensin II Exerts Pressor Effects By Stimulating Renin And Aldosterone Synthase Gene Expression.
Herpes Zoster
Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production.
Herpes Zoster
Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma.
Herpes Zoster
Zona glomerulosa-specific factor: cloning and function.
Herpes Zoster
Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.
Herpes Zoster
Zone-specific expression of aldosterone synthase cytochrome P-450 and cytochrome P-45011 beta in rat adrenal cortex: histochemical basis for the functional zonation.
Herpes Zoster
Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.
Herpes Zoster
[Construction of transgenic mice with specific Cre recombinase expression in the zona fasciculata in adrenal cortex].
Herpes Zoster
[The mechanisms of corticoids biosynthesis revealed by immunohistochemistry and in situ hybridization]
Hirsutism
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
Hirsutism
Comprehensive genotyping of Turkish women with hirsutism.
Hirsutism
Congenital adrenal hyperplasia.
Hirsutism
Late-onset congenital adrenal hyperplasia in women with hirsutism.
Hirsutism
Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
Hirsutism
The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population.
Hirsutism
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
Hyperaldosteronism
'Treasure your exceptions': what we can learn from autosomal-dominant inherited forms of hypertension.
Hyperaldosteronism
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
Hyperaldosteronism
11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension?
Hyperaldosteronism
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Hyperaldosteronism
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
Hyperaldosteronism
A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism.
Hyperaldosteronism
A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes Familial Hyperaldosteronism type I.
Hyperaldosteronism
A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension.
Hyperaldosteronism
A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.
Hyperaldosteronism
A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism.
Hyperaldosteronism
A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism.
Hyperaldosteronism
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22).
Hyperaldosteronism
Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism.
Hyperaldosteronism
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
Hyperaldosteronism
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Hyperaldosteronism
Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation.
Hyperaldosteronism
Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions.
Hyperaldosteronism
Aldosterone secretion a molecular perspective.
Hyperaldosteronism
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Hyperaldosteronism
Aldosterone synthase gene in patients suffering from hyperaldosteronism.
Hyperaldosteronism
Aldosterone synthase inhibition in humans.
Hyperaldosteronism
Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.
Hyperaldosteronism
Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
Hyperaldosteronism
Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.
Hyperaldosteronism
Altered 11 beta-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism.
Hyperaldosteronism
Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis.
Hyperaldosteronism
Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.
Hyperaldosteronism
Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.
Hyperaldosteronism
Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2.
Hyperaldosteronism
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.
Hyperaldosteronism
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
Hyperaldosteronism
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Hyperaldosteronism
CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.
Hyperaldosteronism
Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
Hyperaldosteronism
Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism.
Hyperaldosteronism
Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.
Hyperaldosteronism
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
Hyperaldosteronism
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Hyperaldosteronism
Disordered CYP11B2 Expression in Primary Aldosteronism.
Hyperaldosteronism
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3.
Hyperaldosteronism
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Hyperaldosteronism
DNA Methylation of Steroidogenic Enzymes in Benign Adrenocortical Tumors: New Insights in Aldosterone-Producing Adenomas.
Hyperaldosteronism
Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase.
Hyperaldosteronism
Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.
Hyperaldosteronism
Endocrine causes of hypertension.
Hyperaldosteronism
Evidence for persistent dysfunction of wild-type aldosterone synthase gene in glucocorticoid-treated familial hyperaldosteronism type I.
Hyperaldosteronism
Expression of aldosterone synthase and adrenocorticotropic hormone receptor in adrenal incidentalomas from normotensive and hypertensive patients: Distinguishing subclinical or atypical primary aldosteronism from adrenal incidentaloma.
Hyperaldosteronism
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Hyperaldosteronism
Familial hyperaldosteronism type II: description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene.
Hyperaldosteronism
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Hyperaldosteronism
Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension.
Hyperaldosteronism
Genetic alterations in patients with primary aldosteronism.
Hyperaldosteronism
Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism.
Hyperaldosteronism
Genetic aspects of primary hyperaldosteronism.
Hyperaldosteronism
Genetic causes of primary aldosteronism.
Hyperaldosteronism
Genetic determinants of human hypertension.
Hyperaldosteronism
Genetic determination of human essential hypertension.
Hyperaldosteronism
Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.
Hyperaldosteronism
Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene.
Hyperaldosteronism
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree.
Hyperaldosteronism
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Hyperaldosteronism
Glucocorticoid-suppressible hyperaldosteronism: effects of crossover site and parental origin of chimaeric gene on phenotypic expression.
Hyperaldosteronism
Haplotype analysis of CYP11B2.
Hyperaldosteronism
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Hyperaldosteronism
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
Hyperaldosteronism
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Hyperaldosteronism
Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.
Hyperaldosteronism
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Hyperaldosteronism
Hyper- and hypoaldosteronism.
Hyperaldosteronism
Hyperaldosteronism in pregnancy.
Hyperaldosteronism
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Hyperaldosteronism
Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection.
Hyperaldosteronism
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Hyperaldosteronism
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.
Hyperaldosteronism
Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up.
Hyperaldosteronism
In familial hyperaldosteronism type I, hybrid gene-induced aldosterone production dominates that induced by wild-type genes.
Hyperaldosteronism
Low-renin hypertension: more common than we think?
Hyperaldosteronism
Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?
Hyperaldosteronism
Monogenic low renin hypertension.
Hyperaldosteronism
Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.
Hyperaldosteronism
Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas.
Hyperaldosteronism
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
Hyperaldosteronism
New aspects on primary aldosteronism.
Hyperaldosteronism
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11{beta}-hydroxylase inhibitor metyrapone.
Hyperaldosteronism
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome).
Hyperaldosteronism
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.
Hyperaldosteronism
Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate.
Hyperaldosteronism
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Hyperaldosteronism
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Hyperaldosteronism
Primary Aldosteronism: Where Are We Now? Where to from Here?
Hyperaldosteronism
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology.
Hyperaldosteronism
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Hyperaldosteronism
Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation.
Hyperaldosteronism
Rapid diagnosis and identification of cross-over sites in patients with glucocorticoid remediable aldosteronism.
Hyperaldosteronism
Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism.
Hyperaldosteronism
Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism.
Hyperaldosteronism
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Hyperaldosteronism
Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas.
Hyperaldosteronism
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma.
Hyperaldosteronism
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
Hyperaldosteronism
The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role.
Hyperaldosteronism
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity.
Hyperaldosteronism
The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression.
Hyperaldosteronism
The genetic basis of hypertension.
Hyperaldosteronism
The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism?
Hyperaldosteronism
The Role of the CYP11B2 Promoter Polymorphism in the Diagnosis of Primary Aldosteronism.
Hyperaldosteronism
[11-beta-hydroxylase deficiency and glucocorticoid-sensitive hyperaldosteronism]
Hyperaldosteronism
[Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]
Hyperaldosteronism
[Endocrine and neurogenic hypertension in childhood]
Hyperaldosteronism
[Mineralocorticoid syndromes and hypertension]
Hyperaldosteronism
[Primary aldosteronism: new insights into familial forms].
Hyperaldosteronism
[Progress on genetic basis of primary aldosteronism].
Hyperalgesia
Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.
Hyperandrogenism
11 beta-hydroxylase deficiency in hyperandrogenism.
Hyperandrogenism
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
Hyperandrogenism
Hyperandrogenism: new insights into etiology, diagnosis, and therapy.
Hyperandrogenism
Late onset adrenocortical hydroxylase deficiencies associated with menstrual dysfunction.
Hyperandrogenism
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Hyperglycemia
Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor.
Hyperhomocysteinemia
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Hyperkalemia
Abnormalities of aldosterone synthesis and action in children.
Hyperkalemia
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
Hyperkalemia
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Hyperkalemia
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
Hyperkalemia
Disorders of steroid 11 beta-hydroxylase isozymes.
Hyperkalemia
Mitigating risk of aldosterone in diabetic kidney disease.
Hyperphosphatemia
Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells.
Hyperpituitarism
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
Hyperprolactinemia
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.
Hypersensitivity
Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats.
Hypersensitivity
Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.
Hypertension
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
Hypertension
-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.
Hypertension
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
Hypertension
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
Hypertension
A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function.
Hypertension
A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension.
Hypertension
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
Hypertension
A patent review of aldosterone synthase inhibitors (2014-present).
Hypertension
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
Hypertension
A role for steroid hormones in the variability of blood pressure determination.
Hypertension
A role for the NGFI-B family in adrenal zonation and adrenocortical disease.
Hypertension
A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han.
Hypertension
A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis.
Hypertension
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
Hypertension
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
Hypertension
ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.
Hypertension
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Hypertension
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension.
Hypertension
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients.
Hypertension
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
Hypertension
Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study.
Hypertension
Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population.
Hypertension
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Hypertension
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Hypertension
Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension.
Hypertension
Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy.
Hypertension
Aldosterone synthase inhibition in humans.
Hypertension
Aldosterone synthase inhibition in hypertension.
Hypertension
Aldosterone synthase inhibitors in hypertension: current status and future possibilities.
Hypertension
Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial.
Hypertension
Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals.
Hypertension
Allele, Genotype and Haplotype Structures of Functional Polymorphic Variants in Endothelial Nitric Oxide Synthase (eNOS), Angiotensinogen (ACE) and Aldosterone Synthase (CYP11B2) Genes in Healthy Pregnant Women of Indian Ethnicity.
Hypertension
Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency.
Hypertension
Analysis of the Aldosterone Synthase (CYP11B2) and 11?-Hydroxylase (CYP11B1) Genes.
Hypertension
Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia.
Hypertension
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.
Hypertension
Association between renin-angiotensin-aldosterone system-related genes and blood pressure in a Korean population.
Hypertension
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Hypertension
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Hypertension
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Hypertension
Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals.
Hypertension
Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.
Hypertension
Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.
Hypertension
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Hypertension
Association of the -344T/C aldosterone synthase gene variant with essential hypertension.
Hypertension
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
Hypertension
Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.
Hypertension
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Hypertension
Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: a case-control study.
Hypertension
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
Hypertension
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
Hypertension
Blood pressure in relation to three candidate genes in a Chinese population.
Hypertension
Carotid and femoral intima-media thickness in relation to three candidate genes in a Caucasian population.
Hypertension
Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats.
Hypertension
Central neuromodulatory pathways regulating sympathetic activity in hypertension.
Hypertension
Characterization of the enzyme involved in the production of 19-Nor-deoxycorticosterone in hamster.
Hypertension
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Hypertension
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Hypertension
Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.
Hypertension
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Hypertension
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Hypertension
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
Hypertension
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Hypertension
Congenital adrenal hyperplasia due to 11-hydroxylase enzyme deficiency in three siblings. A brief report.
Hypertension
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
Hypertension
Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population.
Hypertension
Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2.
Hypertension
CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
Hypertension
CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.
Hypertension
CYP11B2 gene polymorphisms and hypertension in highlanders accustomed to high salt intake.
Hypertension
CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study.
Hypertension
Defects in cortisol metabolism causing low-renin hypertension.
Hypertension
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Hypertension
Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms.
Hypertension
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Hypertension
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Hypertension
Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies.
Hypertension
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
Hypertension
Disorders of steroid 11 beta-hydroxylase isozymes.
Hypertension
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Hypertension
Distribution and phenotypic expression of mineralocorticoid receptor and CYP11B2 T-344C polymorphisms in a Taiwanese hypertensive population.
Hypertension
Dopamine and the kidney: a role in hypertension?
Hypertension
Dysregulation of adrenal 11 beta-hydroxylase activity in hypertensive subjects: usefulness of the ACTH 1-17 stimulation test.
Hypertension
Editorial Comment from Dr Fang to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Hypertension
Editorial Comment from Dr Ishidoya to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Hypertension
Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.
Hypertension
Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial.
Hypertension
Effects of alcohol on blood pressure and production of vascular aldosterone and corticosterone.
Hypertension
Effects of cholic acid on blood pressure and production of vascular aldosterone and corticosterone.
Hypertension
Effects of glycyrrhizin on production of vascular aldosterone and corticosterone.
Hypertension
Efficacy and safety of LCI699 for hypertension: a meta-analysis of randomized controlled trials and systematic review.
Hypertension
Endocrine causes of hypertension.
Hypertension
Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Hypertension
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Hypertension
Familial hyperaldosteronism.
Hypertension
Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene.
Hypertension
Gene variants of aldosterone synthase and hypertension.
Hypertension
Genetic approach to diagnostic and therapeutic decisions in human hypertension.
Hypertension
Genetic aspects of congenital adrenal hyperplasia.
Hypertension
Genetic determinants of human hypertension.
Hypertension
Genetic determination of human essential hypertension.
Hypertension
Genetic Influence on Baroreflex Sensitivity in Normotensive Young Men.
Hypertension
Genetic polymorphism of CYP11B2 gene and hypertension in Japanese.
Hypertension
Genetic predisposition to salt-sensitivity: a systematic review.
Hypertension
Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.
Hypertension
Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes.
Hypertension
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
Hypertension
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
Hypertension
Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion.
Hypertension
Genetic variation in P450c11AS in Chilean patients with low renin hypertension.
Hypertension
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree.
Hypertension
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Hypertension
Haplotype analysis of CYP11B2.
Hypertension
Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.
Hypertension
Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.
Hypertension
Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan: the Ohasama study.
Hypertension
Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese.
Hypertension
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Hypertension
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Hypertension
Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.
Hypertension
High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells.
Hypertension
High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.
Hypertension
HindIII(+/-) Polymorphism of the Y Chromosome, Blood Pressure, and Serum Lipids: No Evidence of Association in Three White Populations.
Hypertension
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Hypertension
Hormonal hypertension in children: 11beta-hydroxylase deficiency and apparent mineralocorticoid excess.
Hypertension
Human aldosterone synthase gene polymorphism promotes miRNA binding and regulates gene expression.
Hypertension
Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level.
Hypertension
Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3.
Hypertension
Hyperaldosteronism in pregnancy.
Hypertension
Hypertension and oedema caused by cortexone hyperproduction and cured by monolateral adrenalectomy. Case report.
Hypertension
Hypertension in a neonate with 11 beta-hydroxylase deficiency.
Hypertension
Hypertension in a patient with aldosterone deficiency.
Hypertension
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Hypertension
Imidazopyridyl compounds as aldosterone synthase inhibitors.
Hypertension
Impact of Aldosterone Synthase Gene C-344T Polymorphism on IgA Nephropathy.
Hypertension
Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension.
Hypertension
Inborn errors of adrenal steroidogenesis.
Hypertension
Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis.
Hypertension
Influence of CYP11B2 gene polymorphism on the prevalence of hypertension and the blood pressure in Japanese men: interaction with dietary salt intake.
Hypertension
Insights on the phenotypic heterogenity of 11?-hydroxylase deficiency: clinical and genetic studies in two novel families.
Hypertension
Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population.
Hypertension
Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?
Hypertension
Juvenile hypertension, the role of genetically altered steroid metabolism.
Hypertension
Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study.
Hypertension
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Hypertension
Letter by Keidar and Gamliel-Lazarovich regarding article, "Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial".
Hypertension
Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension.
Hypertension
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Hypertension
Mechanisms of hypertension: the expanding role of aldosterone.
Hypertension
Mineralocorticoid Actions in the Brain and Hypertension.
Hypertension
Modulation of aldosterone levels by -344 C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension.
Hypertension
Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.
Hypertension
Monogenic low renin hypertension.
Hypertension
Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort.
Hypertension
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Hypertension
Mutations in human 11 beta-hydroxylase genes: 11 beta-hydroxylase deficiency in Jews of Morocco and corticosterone methyl-oxidase II deficiency in Jews of Iran.
Hypertension
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Hypertension
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
Hypertension
New drugs, procedures, and devices for hypertension.
Hypertension
Novel homozygous p.Y395X mutation in the CYP11B1 gene found in a Vietnamese patient with 11?-hydroxylase deficiency.
Hypertension
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
Hypertension
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Hypertension
Pharmacophore Modeling and
Hypertension
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Hypertension
Polymorphism of CYP11B2 determines salt sensitivity in Japanese.
Hypertension
Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients.
Hypertension
Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension.
Hypertension
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Hypertension
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Hypertension
Prolongation of growth by treatment of 11-hydroxylase deficiency with depot-leuprolide, growth hormone, and hydrocortisone.
Hypertension
RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension.
Hypertension
Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size.
Hypertension
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Hypertension
Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake.
Hypertension
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
Hypertension
Renal function in relation to three candidate genes.
Hypertension
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Hypertension
Salt sensitivity of Japanese from the viewpoint of gene polymorphism.
Hypertension
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Hypertension
Steroid responsive hypertension secondary to 11-beta hydroxylase deficiency--a case report.
Hypertension
Structural analysis and evaluation of the aldosterone synthase gene in hypertension.
Hypertension
Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Hypertension
Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension.
Hypertension
Study of aldosterone synthase inhibition as an add-on therapy in resistant hypertension.
Hypertension
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
Hypertension
T allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension.
Hypertension
The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese.
Hypertension
The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension.
Hypertension
The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients.
Hypertension
The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Hypertension
The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity.
Hypertension
The Effects of Aldosterone Synthase Inhibition on Aldosterone and Cortisol in Patients With Hypertension: A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study.
Hypertension
The genetic basis of essential hypertension.
Hypertension
The genetic basis of hypertension.
Hypertension
The human genome contains only two CYP11B (P450c11) genes.
Hypertension
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
Hypertension
The inhibition of rat adrenal cytochrome P-45011 beta gene expression by androgens.
Hypertension
The relation between ACE D/I and CYP11B2 C-344T polymorphisms and parameters of arterial stiffness in the context of renal sodium handling.
Hypertension
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
Hypertension
Trilostane, FAD286, and the role of aldosterone in the central regulation of blood pressure: focus on "Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats".
Hypertension
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Hypertension
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Hypertension
Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.
Hypertension
Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
Hypertension
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
Hypertension
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
Hypertension
[Association of the complex of polymorphic markers of ACE genes, aldosteron synthetase and endothelial synthetase of nitric oxide with progression of chronic glomerulonephritis]
Hypertension
[Association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B2 with essential hypertension in Xinjiang Kazakh isolated group.]
Hypertension
[Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]
Hypertension
[Correlativity between the polymorphisms of aldosterone synthase gene, Hind III restriction site on Y chromosome and essential hypertension]
Hypertension
[Deficiency of 11-hydroxylase in a case of congenital hyperplasia of the adrenal glands without arterial hypertension; clinical and biological study.]
Hypertension
[Female pseudo-hermaphroditism with complete virilism and arterial hypertension due to an 11-beta-hydroxylase defect diagnosed in an adult]
Hypertension
[Hypertension and gene polymorphisms]
Hypertension
[Hypertension-induced fibrosis: A balance story].
Hypertension
[Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population]
Hypertension
[Increase in plasma and urinary 17-hydroxycorticoids in a case of congenital hyperplasia of the adrenals without arterial hypertension. Identification of abnormal steroids related to a deficiency of 11beta-hydroxylase.]
Hypertension
[Mineralocorticoid syndromes and hypertension]
Hypertension
[New techniques and laboratory examinations in the detection and evaluation of hypertension]
Hypertension
[Promoter variants of aldosterone synthase gene (CYP11B2) and salt-sensitivity of blood pressure]
Hypertension
[Single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of arctic zone of yakutia suffering from arterial hypertension].
Hypertension
[Single nucleotide polymorphisms of three candidate genes in essential hypertension]
Hypertension
[Strategy for studying mineralocorticoids other than aldosterone in arterial hypertension of hormonal origin]
Hypertension
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
Hypertension
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Hypertension, Malignant
Deoxycorticosterone, 11 beta-hydroxylase and the adrenal cortex.
Hypertension, Malignant
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Hypertension, Pregnancy-Induced
Aldosterone synthase gene polymorphism is not associated with gestational hypertension or preeclampsia.
Hypertension, Pregnancy-Induced
Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension.
Hypertension, Renovascular
A role for steroid hormones in the variability of blood pressure determination.
Hypertrophy, Left Ventricular
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension.
Hypertrophy, Left Ventricular
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial.
Hypertrophy, Left Ventricular
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Hypertrophy, Left Ventricular
Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis.
Hypertrophy, Left Ventricular
Association of the -344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis.
Hypertrophy, Left Ventricular
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
Hypertrophy, Left Ventricular
[Hereditary factors and left ventricular hypertrophy]
Hypertrophy, Left Ventricular
[Specifics of distribution of polymorphic markers of the renin-angiotensin-system genes, relation to ventricular hypertrophy in patients with essential hypertension of Uzbek nationality]
Hypertrophy, Left Ventricular
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
Hypoadrenocorticism, Familial
Aldosterone signaling defect in young infants: single-center report and review.
Hypoadrenocorticism, Familial
Effects of fetal androgen on childhood behavior.
Hypoaldosteronism
A case of primary selective hypoaldosteronism carrying three mutations in the aldosterone synthase (Cyp11b2) gene.
Hypoaldosteronism
A missense mutation (GGC[435Gly]-->AGC[Ser]) in exon 8 of the CYP11B2 gene inherited in Japanese patients with congenital hypoaldosteronism.
Hypoaldosteronism
Aldosterone synthase deficiency and related disorders.
Hypoaldosteronism
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
Hypoaldosteronism
Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2.
Hypoaldosteronism
Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.
Hypoaldosteronism
Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene.
Hypoaldosteronism
Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene.
Hypoaldosteronism
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
Hypoaldosteronism
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Hypoaldosteronism
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.
Hypoaldosteronism
Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency.
Hypoaldosteronism
Homozygous deletion of arginine-173 in the CYP11B2 gene in a girl with congenital hypoaldosteronism. Corticosterone methyloxidase deficiency type II.
Hypoaldosteronism
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency.
Hypoaldosteronism
Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency.
Hypoaldosteronism
The Aldosterone/Renin Ratio as a Diagnostic Tool for the Diagnosis of Primary Hypoaldosteronism in Newborns and Infants.
Hypoaldosteronism
Type 1 aldosterone synthase deficiency presenting in a middle-aged man.
Hypoaldosteronism
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Hypokalemia
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
Hypokalemia
A novel CYP11B1 mutation in a Turkish patient with 11?-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Hypokalemia
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Hypokalemia
New aspects of mineralocorticoid hypertension.
Hypokalemia
Steroids and hypertension.
Hyponatremia
A compound heterozygote case of type II aldosterone synthase deficiency.
Hyponatremia
Abnormalities of aldosterone synthesis and action in children.
Hyponatremia
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
Hyponatremia
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Hyponatremia
Disorders of steroid 11 beta-hydroxylase isozymes.
Hyponatremia
Hypertension in a patient with aldosterone deficiency.
Hypospadias
Aldosterone synthase deficiency type II with hypospadias.
Hypospadias
Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization.
Hypotension
Association of renin-angiotensin-aldosterone system genetic polymorphisms with maternal hypotension during spinal anaesthesia for caesarean delivery - a retrospective cohort study.
Hypotension, Orthostatic
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
Infertility
Congenital adrenal hyperplasia.
Insulin Resistance
Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population.
Insulin Resistance
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Insulin Resistance
The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families.
Ischemic Attack, Transient
Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population.
Ischemic Stroke
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Ischemic Stroke
Association of CYP11B2 gene polymorphism with ischemic stroke in the north Chinese Han population.
Ischemic Stroke
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Ischemic Stroke
Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis.
Ischemic Stroke
Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects.
Ischemic Stroke
The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis.
Ischemic Stroke
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
Ischemic Stroke
[Association study of polymorphic markers of F12, PON1, PON2, NOS2, PDE4D, HIF1a, GPIba, CYP11B2 genes with ischemic stroke in Russian patients].
Kidney Failure, Chronic
Aldosterone Synthase Gene (CYP11B2) Polymorphism in Korean End-Stage Renal Disease Patients on Hemodialysis.
Kidney Failure, Chronic
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats.
Kidney Neoplasms
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Leiomyoma
Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5 alpha-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing enzymes.
Leukemia
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.
Leydig Cell Tumor
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor.
Liddle Syndrome
Genetic determinants of human hypertension.
Liver Cirrhosis
[CYP11B2 expression in rat liver and the efficacy of antisterone on liver fibrosis]
Malnutrition
Maternal Undernutrition Programs Offspring Adrenal Expression of Steroidogenic Enzymes.
Melanoma
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.
Metabolic Diseases
An inherited defect in aldosterone biosynthesis caused by a mutation in or near the gene for steroid 11-hydroxylase.
Metabolic Diseases
Optimization of the First Selective Steroid-11?-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Metabolic Diseases
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Metabolic Syndrome
-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.
Metabolic Syndrome
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Metabolic Syndrome
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Metabolic Syndrome
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Metabolic Syndrome
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Mitral Valve Insufficiency
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Muscle Weakness
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Muscular Diseases
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Myocardial Infarction
Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction.
Myocardial Infarction
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Myocardial Infarction
Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Myocardial Infarction
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
Myocardial Infarction
[Genetic factors in myocardial infarction--Results from a candidate gene and a genome-wide approach between beta blockers]
Myocarditis
Evidence of aldosterone synthesis in human myocardium in acute myocarditis.
nadph-hemoprotein reductase deficiency
Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol.
Nasal Polyps
The expression of 11?-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp.
Neoplasms
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Neoplasms
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
Neoplasms
A cAMP-responsive element regulates expression of the mouse steroid 11 beta-hydroxylase gene.
Neoplasms
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
Neoplasms
A Novel Somatic Deletion Mutation of ATP2B3 in Aldosterone-Producing Adenoma.
Neoplasms
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
Neoplasms
Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours.
Neoplasms
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Neoplasms
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Neoplasms
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Neoplasms
Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes.
Neoplasms
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Neoplasms
Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor.
Neoplasms
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Neoplasms
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Neoplasms
Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs.
Neoplasms
Characterization of the hamster CYP11B2 gene regulatory regions.
Neoplasms
Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases.
Neoplasms
Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome.
Neoplasms
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.
Neoplasms
Cloning of cDNA and genomic DNA for human cytochrome P-45011 beta.
Neoplasms
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Neoplasms
Cortisol production by testicular tumors in a patient with congenital adrenal hyperplasia (21-hydroxylase deficiency).
Neoplasms
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Neoplasms
Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study.
Neoplasms
Double adenomas with different pathological and hormonal features in the left adrenal gland of a patient with Cushing's syndrome.
Neoplasms
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Neoplasms
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma.
Neoplasms
Evidence of 11 beta-hydroxylase deficiency in childhood adrenocortical tumors. The plasma corticosterone/11-deoxycorticosterone ratio as a possible marker for malignancy.
Neoplasms
Expression of steroidogenic enzymes and their transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and quantitative real-time polymerase chain reaction studies.
Neoplasms
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor.
Neoplasms
Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary aldosteronism: an insight into the underlying mechanism.
Neoplasms
Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism.
Neoplasms
Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.
Neoplasms
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
Neoplasms
GENETICS IN ENDOCRINOLOGY: Impact of race and sex on genetic causes of aldosterone-producing adenomas.
Neoplasms
H-score of 11?-hydroxylase and aldosterone synthase in the histopathological diagnosis of adrenocortical tumors.
Neoplasms
Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations.
Neoplasms
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Neoplasms
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Neoplasms
Imaging of adrenal masses with emphasis on adrenocortical tumors.
Neoplasms
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Neoplasms
Impairment of 11 beta-hydroxylase but not 21-hydroxylase in adrenal 'incidentalomas'.
Neoplasms
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
Neoplasms
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Neoplasms
Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumours.
Neoplasms
Integrated Analysis of Genome-wide Methylation and Gene Expression Shows Epigenetic Regulation of CYP11B2 in Aldosteronomas.
Neoplasms
Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study.
Neoplasms
Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats.
Neoplasms
Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells.
Neoplasms
MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.
Neoplasms
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Neoplasms
New aspects of mineralocorticoid hypertension.
Neoplasms
Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice.
Neoplasms
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Neoplasms
Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders.
Neoplasms
Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor.
Neoplasms
PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate.
Neoplasms
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome).
Neoplasms
Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population.
Neoplasms
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Neoplasms
Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin.
Neoplasms
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Neoplasms
Stable expression of rat cytochrome P450 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in MA-10 cells.
Neoplasms
Steroid contents and cortical steroidogenic enzymes in non-hyperfunctioning adrenal adenoma.
Neoplasms
Steroid profile in urine: a useful tool in the diagnosis and follow up of adrenocortical carcinoma.
Neoplasms
Steroidogenesis in isolated cells and mitochondria of rat Snell adrenocortical carcinoma 494.
Neoplasms
Steroids and hypertension.
Neoplasms
SY 03-3 OVERVIEW OF SOMATIC MUTATIONS AND EPIGENETIC REGULATION OF ALDOSTERONE PRODUCING ADENOMA (APA).
Neoplasms
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Neoplasms
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Neoplasms
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Neoplasms
Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue.
Neoplasms
The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
Neoplasms
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant "neoplastic" steroidogenesis in adrenals.
Neoplasms
The impact of gene polymorphisms in angiotensin receptor 1 and aldosterone synthase in peritoneal dialysis patients.
Neoplasms
The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.
Neoplasms
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
Neoplasms
The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
Neoplasms
The steroid metabolite 16(?)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.
Neoplasms
Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression.
Neoplasms
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma.
Neoplasms
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Neoplasms
Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma.
Neoplasms
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
Neoplasms
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
Neoplasms
Wnt/?-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice.
Neoplasms
[Endocrine and neurogenic hypertension in childhood]
Neoplasms
[Medical treatment for Cushing's syndrome]
Neoplasms
[Primary hyperaldosteronism and adenoma of the adrenal cortex. Suppression of aldosterone with dexamethasone]
Neoplasms
[Treatment of male adrenogenital syndrome (report of 17 cases)]
Nephrocalcinosis
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
Nephrocalcinosis
Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme.
Nephrotic Syndrome
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Neuroblastoma
[Endocrine and neurogenic hypertension in childhood]
Obesity
Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.
Obesity
Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism.
Obesity
Impact of Adrenal Steroids on Regulation of Adipose Tissue.
Obesity
Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.
Ovarian Diseases
Polycystic ovarian disease and congenital and late-onset adrenal hyperplasia.
Peritoneal Fibrosis
The impact of gene polymorphisms in angiotensin receptor 1 and aldosterone synthase in peritoneal dialysis patients.
Pheochromocytoma
Endocrine causes of hypertension.
Pheochromocytoma
Steroid enzyme activities in extraadrenal pheochromocytomas.
Pheochromocytoma
[Endocrine and neurogenic hypertension in childhood]
Pituitary ACTH Hypersecretion
Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design.
Pituitary ACTH Hypersecretion
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Pituitary ACTH Hypersecretion
Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase.
Pituitary ACTH Hypersecretion
Investigating mineralocorticoid hypertension.
Pituitary ACTH Hypersecretion
Ketoconazole and plasma and urine steroid levels in Cushing's disease.
Pituitary ACTH Hypersecretion
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.
Pituitary ACTH Hypersecretion
Osilodrostat: A Novel Steroidogenesis Inhibitor to Treat Cushing's Disease.
Pituitary ACTH Hypersecretion
Partial 11 beta-hydroxylase activity suppression after dexamethasone in patients with major depression.
Pituitary ACTH Hypersecretion
Preclinical Cushing's disease characterized by massive adrenal hyperplasia and hormonal changes after three years of metyrapone therapy.
Pituitary ACTH Hypersecretion
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
Pituitary ACTH Hypersecretion
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Pituitary ACTH Hypersecretion
Use of ketoconazole in the treatment of Cushing's syndrome.
Polycystic Kidney Diseases
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
11 beta-Hydroxylase with affinity to C-21-Deoxysteroids from ovaries of patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Evidence for adrenal and/or ovarian dysfunction as a possible etiology of idiopathic hirsutism.
Polycystic Ovary Syndrome
Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation.
Polycystic Ovary Syndrome
The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome.
Post-Exercise Hypotension
Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans.
Pre-Eclampsia
Aldosterone synthase gene polymorphism is not associated with gestational hypertension or preeclampsia.
Pre-Eclampsia
Allele, Genotype and Haplotype Structures of Functional Polymorphic Variants in Endothelial Nitric Oxide Synthase (eNOS), Angiotensinogen (ACE) and Aldosterone Synthase (CYP11B2) Genes in Healthy Pregnant Women of Indian Ethnicity.
Pre-Eclampsia
Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia.
Pre-Eclampsia
Association of CYP11B2 gene polymorphism with preeclampsia in north east of Iran (Khorasan province).
Pre-Eclampsia
Correlation between CYP11B2 polymorphism and the risk of preeclampsia.
Pre-Eclampsia
Evidence for compromised aldosterone synthase enzyme activity in preeclampsia.
Pre-Eclampsia
High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.
Pre-Eclampsia
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Pre-Eclampsia
MiR-4421 regulates the progression of preeclampsia by regulating CYP11B2.
Pre-Eclampsia
OS058. Aldosterone deficiency adversely affects pregnancy outcome in mice.
Pre-Eclampsia
Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension.
Pre-Eclampsia
Renin-angiotensin system gene variants and risk of early- and late-onset preeclampsia: A single center case-control study.
Prostatic Neoplasms
Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.
Proteinuria
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Pseudohypoaldosteronism
Epidemiologic study of adrenal gland disorders in Japan.
Pseudohypoaldosteronism
Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism.
Pseudotumor Cerebri
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
Puberty, Precocious
Benign testicular tumors in children with congenital adrenal hyperplasia.
Puberty, Precocious
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Puberty, Precocious
Combination growth hormone and gonadotropin releasing hormone analog therapy in 11beta-hydroxylase deficiency.
Puberty, Precocious
Genetic aspects of congenital adrenal hyperplasia.
Puberty, Precocious
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Puberty, Precocious
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Puberty, Precocious
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
Puberty, Precocious
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Puberty, Precocious
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Pulmonary Edema
Association of polymorphisms in angiotensin and aldosterone synthase genes of the renin-angiotensin-aldosterone system with high-altitude pulmonary edema.
Pulmonary Valve Stenosis
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
Pulmonary Valve Stenosis
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Renal Insufficiency
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.
Renal Insufficiency, Chronic
Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
Renal Insufficiency, Chronic
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Renal Insufficiency, Chronic
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy.
Renal Insufficiency, Chronic
Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms.
Renal Insufficiency, Chronic
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Renal Insufficiency, Chronic
Modulation of aldosterone levels by aldosterone synthase promoter polymorphism and association with eGFR decline in patients with chronic kidney disease.
Respiratory Distress Syndrome
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
Rhabdomyolysis
A novel CYP11B1 mutation in a Turkish patient with 11?-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Rhabdomyolysis
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Seizures
11?-Hydoxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis.
Seizures
Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures.
Sepsis
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
Sepsis
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
Sepsis
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
Sepsis
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
Sepsis
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Sepsis
Retraction notice.
Starvation
Acute starvation affects rat adrenal steroidogenesis.
steroid 11beta-monooxygenase deficiency
"Masked" 21-hydroxylase deficiency of the adrenal presenting with gynecomastia and bilateral testicular masses.
steroid 11beta-monooxygenase deficiency
11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis.
steroid 11beta-monooxygenase deficiency
11 beta-hydroxylase deficiency in hyperandrogenism.
steroid 11beta-monooxygenase deficiency
11 Beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
steroid 11beta-monooxygenase deficiency
11-deoxycortisol in amniotic fluid: prenatal diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia.
steroid 11beta-monooxygenase deficiency
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
steroid 11beta-monooxygenase deficiency
11beta-hydroxylase deficiency masked by alternative medicines.
steroid 11beta-monooxygenase deficiency
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
21-hydroxylase deficiency transiently mimicking combined 21- and 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
steroid 11beta-monooxygenase deficiency
9alpha-Fluorohydrocortisone therapy in aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
A 5-year-old boy with cryptorchidism and pubic hair: investigation and management of apparent male disorders of sex development in mid-childhood.
steroid 11beta-monooxygenase deficiency
A Case of 11beta-Hydroxylase Deficiency Detected in a Newborn Screening Program by Second-Tier LC-MS/MS.
steroid 11beta-monooxygenase deficiency
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
steroid 11beta-monooxygenase deficiency
A compound heterozygote case of type II aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.
steroid 11beta-monooxygenase deficiency
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
A novel CYP11B2 gene mutation in an Asian family with aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
A novel missense mutation, GGC(Arg454) --> TGC(Cys), of CYP11B1 gene identified in a Chinese family with steroid 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
A particular phenotype in a girl with aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
steroid 11beta-monooxygenase deficiency
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs.
steroid 11beta-monooxygenase deficiency
Abnormalities of aldosterone synthesis and action in children.
steroid 11beta-monooxygenase deficiency
Absence of nonclassical congenital adrenal hyperplasia in patients with precocious adrenarche.
steroid 11beta-monooxygenase deficiency
Absence of steroid biosynthetic defects in heterozygote individuals for classic 11 beta-hydroxylase deficiency due to a R448H mutation in the CYP11B1 gene.
steroid 11beta-monooxygenase deficiency
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
steroid 11beta-monooxygenase deficiency
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
steroid 11beta-monooxygenase deficiency
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
steroid 11beta-monooxygenase deficiency
Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche.
steroid 11beta-monooxygenase deficiency
ADRENOCORTICAL 11-BETA-HYDROXYLASE DEFICIENCY AND VIRILISM FIRST MANIFEST IN THE ADULT WOMEN.
steroid 11beta-monooxygenase deficiency
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
steroid 11beta-monooxygenase deficiency
Aldosterone secretion a molecular perspective.
steroid 11beta-monooxygenase deficiency
Aldosterone signaling defect in young infants: single-center report and review.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase (CYP11B2) deficiency among Palestinian infants: Three novel variants and genetic heterogeneity.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency and related disorders.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency type I with no documented homozygous mutations in the CYP11B2 gene.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency type I: hormonal and genetic analyses of two cases.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency type II with hypospadias.
steroid 11beta-monooxygenase deficiency
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
steroid 11beta-monooxygenase deficiency
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
steroid 11beta-monooxygenase deficiency
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
steroid 11beta-monooxygenase deficiency
An inherited defect in aldosterone biosynthesis caused by a mutation in or near the gene for steroid 11-hydroxylase.
steroid 11beta-monooxygenase deficiency
Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
steroid 11beta-monooxygenase deficiency
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Androgen metabolism in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Apparent double defect in C11 beta and C21-steroid hydroxylation in congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Benign testicular tumors in children with congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
steroid 11beta-monooxygenase deficiency
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
steroid 11beta-monooxygenase deficiency
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Bone turnover and bone mineral density in patients with congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Catch-up growth and discontinuation of fludrocortisone treatment in aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency.
steroid 11beta-monooxygenase deficiency
Classic steroid 11 beta-hydroxylase deficiency caused by a C-->G transversion in exon 7 of CYP11B1.
steroid 11beta-monooxygenase deficiency
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
steroid 11beta-monooxygenase deficiency
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Clinical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11).
steroid 11beta-monooxygenase deficiency
Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome.
steroid 11beta-monooxygenase deficiency
Combination growth hormone and gonadotropin releasing hormone analog therapy in 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia - how to improve the transition from adolescence to adult life.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia 11beta-hydroxylase deficiency: two cases managed with bilateral adrenalectomy.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia and P450 oxidoreductase deficiency.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency in Saudi Arabia: clinical and biochemical characteristics.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency in a Tunisian family.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: description of a new mutation, R384X.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia in pregnancy.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia in Sweden 1969-1986. Prevalence, symptoms and age at diagnosis.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia masquerading as periodic paralysis in an adolescent girl.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia secondary to 11beta-hydroxylase deficiency in a domestic cat.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia with 11-hydroxylase deficiency. A case report and contribution to diagnosis.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol.
steroid 11beta-monooxygenase deficiency
Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.
steroid 11beta-monooxygenase deficiency
Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene.
steroid 11beta-monooxygenase deficiency
Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene.
steroid 11beta-monooxygenase deficiency
Congenital primary adrenal insufficiency and selective aldosterone defects presenting as salt-wasting in infancy: a single center 10-year experience.
steroid 11beta-monooxygenase deficiency
Correction: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
steroid 11beta-monooxygenase deficiency
Corticosterone Methyl Oxidase Deficiency Type 1 with Normokalemia in an Infant.
steroid 11beta-monooxygenase deficiency
Cortisol production rate in children by gas chromatography/mass spectrometry using [1,2,3,4-13C]cortisol.
steroid 11beta-monooxygenase deficiency
Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family.
steroid 11beta-monooxygenase deficiency
CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
steroid 11beta-monooxygenase deficiency
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Deoxycorticosterone and 17-ketosteroids. Elevated levels in adult hypertensive patients.
steroid 11beta-monooxygenase deficiency
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
steroid 11beta-monooxygenase deficiency
Determination of 11-deoxycortisol (Reichstein's compound S) in human plasma by clinical isotope dilution mass spectrometry using benchtop gas chromatography-mass selective detection.
steroid 11beta-monooxygenase deficiency
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
steroid 11beta-monooxygenase deficiency
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
steroid 11beta-monooxygenase deficiency
Diagnosis of congenital adrenal hyperplasia with 11-hydroxylase deficiency by determination of tetrahydro-11-desoxycortisol in urine.
steroid 11beta-monooxygenase deficiency
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
steroid 11beta-monooxygenase deficiency
Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect.
steroid 11beta-monooxygenase deficiency
Disorders of steroid 11 beta-hydroxylase isozymes.
steroid 11beta-monooxygenase deficiency
Disorders of steroid 17 alpha-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
steroid 11beta-monooxygenase deficiency
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
steroid 11beta-monooxygenase deficiency
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Does primary salt wasting occur in 11-beta-hydroxylase deficiency?
steroid 11beta-monooxygenase deficiency
Donor splice mutation in the 11beta-hydroxylase (CypllB1) gene resulting in sex reversal: a case report and review of the literature.
steroid 11beta-monooxygenase deficiency
Early diagnosis of 11 beta-hydroxylase deficiency in two siblings confirmed by analysis of a novel steroid metabolite in newborn urine.
steroid 11beta-monooxygenase deficiency
Effects of fetal androgen on childhood behavior.
steroid 11beta-monooxygenase deficiency
Endocrine causes of hypertension.
steroid 11beta-monooxygenase deficiency
Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia.
steroid 11beta-monooxygenase deficiency
Evidence for a new biologic pathway of androstenedione synthesis from 11-deoxycortisol.
steroid 11beta-monooxygenase deficiency
Evidence for endocrinological abnormalities in heterozygotes for adrenal 11 beta-hydroxylase deficiency of a family with the R448H mutation in the CYP11B1 gene.
steroid 11beta-monooxygenase deficiency
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
steroid 11beta-monooxygenase deficiency
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
steroid 11beta-monooxygenase deficiency
Evidence of 11 beta-hydroxylase deficiency in childhood adrenocortical tumors. The plasma corticosterone/11-deoxycorticosterone ratio as a possible marker for malignancy.
steroid 11beta-monooxygenase deficiency
Familial pericentric inversion chromosome 3 and R448C mutation of CYP11B1 gene in Turkish kindred with 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.
steroid 11beta-monooxygenase deficiency
Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses.
steroid 11beta-monooxygenase deficiency
Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Gender identity in congenital adrenal hyperplasia secondary to 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Gender Identity in Patients with Congenital Adrenal Hyperplasia.
steroid 11beta-monooxygenase deficiency
Genetic aspects of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Genetic diseases of steroid metabolism.
steroid 11beta-monooxygenase deficiency
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Growth and pubertal development in patients with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Gynaecomastia in two prepubertal boys with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997.
steroid 11beta-monooxygenase deficiency
High frequency of congenital adrenal hyperplasia (classic 11 beta-hydroxylase deficiency) among Jews from Morocco.
steroid 11beta-monooxygenase deficiency
HLA and congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
HLA and hormonal data for identification of heterozygotes in 11 beta- and 17 alpha-hydroxylase deficiency syndromes.
steroid 11beta-monooxygenase deficiency
Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
steroid 11beta-monooxygenase deficiency
Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism.
steroid 11beta-monooxygenase deficiency
Hormonal hypertension in children: 11beta-hydroxylase deficiency and apparent mineralocorticoid excess.
steroid 11beta-monooxygenase deficiency
Hormonal studies in obligate heterozygotes and siblings of patients with 11 beta-hydroxylase deficiency congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Hyperplasia of adrenal rest tissue causing a retroperitoneal mass in a child with 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Hypertension in a neonate with 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Hypertension in a patient with aldosterone deficiency.
steroid 11beta-monooxygenase deficiency
Hypertensive congenital adrenal enzymatic defects detected by high-performance liquid chromatography of corticosteroids.
steroid 11beta-monooxygenase deficiency
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Impairment of 11 beta-hydroxylase but not 21-hydroxylase in adrenal 'incidentalomas'.
steroid 11beta-monooxygenase deficiency
Inborn errors of adrenal steroidogenesis.
steroid 11beta-monooxygenase deficiency
Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene.
steroid 11beta-monooxygenase deficiency
Kinetics and metabolism of 11-deoxycortisol in a patient with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Late-onset congenital adrenal hyperplasia in women with hirsutism.
steroid 11beta-monooxygenase deficiency
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
steroid 11beta-monooxygenase deficiency
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis.
steroid 11beta-monooxygenase deficiency
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
steroid 11beta-monooxygenase deficiency
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Missense mutation in CYP11B1 (CGA[Arg-384]-->GGA[Gly]) causes steroid 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency.
steroid 11beta-monooxygenase deficiency
Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.
steroid 11beta-monooxygenase deficiency
Molecular genetics of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Molecular genetics of disorders of sex development in a highly consanguineous population.
steroid 11beta-monooxygenase deficiency
Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients.
steroid 11beta-monooxygenase deficiency
Mutations in CYP11B1 and congenital adrenal hyperplasia in Moroccan Jews.
steroid 11beta-monooxygenase deficiency
Mutations in CYP11B1 gene: phenotype-genotype correlations.
steroid 11beta-monooxygenase deficiency
Mutations in human 11 beta-hydroxylase genes: 11 beta-hydroxylase deficiency in Jews of Morocco and corticosterone methyl-oxidase II deficiency in Jews of Iran.
steroid 11beta-monooxygenase deficiency
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
steroid 11beta-monooxygenase deficiency
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
steroid 11beta-monooxygenase deficiency
New aspects of mineralocorticoid hypertension.
steroid 11beta-monooxygenase deficiency
New molecular genetic defects causing 11beta-hydroxylase deficiency (CAH).
steroid 11beta-monooxygenase deficiency
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
No linkage between HLA and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Nonclassic 11 beta-hydroxylase deficiency: report of two patients and review.
steroid 11beta-monooxygenase deficiency
Novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency.
steroid 11beta-monooxygenase deficiency
Novel missense mutations, GCC [Ala306]- > GTC [Val] and ACG [Thr318]- > CCG [Pro], in the CYP11B1 gene cause steroid 11beta-hydroxylase deficiency in the Chinese.
steroid 11beta-monooxygenase deficiency
Novel mutations in CYP11B1 gene leading to 11 beta-hydroxylase deficiency in Brazilian patients.
steroid 11beta-monooxygenase deficiency
Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency.
steroid 11beta-monooxygenase deficiency
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
steroid 11beta-monooxygenase deficiency
Over 50 Years of Progress in the Treatment of the Hypertensive Form of Congenital Adrenal Hyperplasia due to Steroid 11-Beta-Hydroxylase Deficiency. Commentary on Simm PJ and Zacharin MR: Successful Pregnancy in a Patient with severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene (Horm Res 2007;68:294-297).
steroid 11beta-monooxygenase deficiency
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
steroid 11beta-monooxygenase deficiency
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
steroid 11beta-monooxygenase deficiency
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
steroid 11beta-monooxygenase deficiency
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
steroid 11beta-monooxygenase deficiency
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
steroid 11beta-monooxygenase deficiency
Prenatal diagnosis of 11beta-hydroxylase deficiency congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Prenatal treatment of congenital adrenal hyperplasia. The United States experience.
steroid 11beta-monooxygenase deficiency
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
steroid 11beta-monooxygenase deficiency
Prevalence of late-onset 11 beta-hydroxylase deficiency in hirsute patients.
steroid 11beta-monooxygenase deficiency
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Prolongation of growth by treatment of 11-hydroxylase deficiency with depot-leuprolide, growth hormone, and hydrocortisone.
steroid 11beta-monooxygenase deficiency
Prostatic ejaculate in assigned males with 46,XX congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
steroid 11beta-monooxygenase deficiency
Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH).
steroid 11beta-monooxygenase deficiency
Regulation of the mineralocorticoid hormones in adrenocortical disorders with adrenocorticotropin excess.
steroid 11beta-monooxygenase deficiency
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
steroid 11beta-monooxygenase deficiency
Requirement of mineralocorticoid in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Restriction fragment length polymorphisms of the CYP11B1 gene in the Japanese population.
steroid 11beta-monooxygenase deficiency
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
steroid 11beta-monooxygenase deficiency
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Serum 11 beta-hydroxyandrostenedione as an indicator of the source of excess androgen production in women with polycystic ovaries.
steroid 11beta-monooxygenase deficiency
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
steroid 11beta-monooxygenase deficiency
Sex reassignment in a girl with 11 beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene.
steroid 11beta-monooxygenase deficiency
Sonographic findings in infants with congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Steroid 11 beta-hydroxylase deficiency and related disorders.
steroid 11beta-monooxygenase deficiency
Steroid 11 beta-hydroxylase deficiency caused by a five base pair duplication in the CYP11B1 gene.
steroid 11beta-monooxygenase deficiency
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
steroid 11beta-monooxygenase deficiency
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
steroid 11beta-monooxygenase deficiency
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
steroid 11beta-monooxygenase deficiency
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients.
steroid 11beta-monooxygenase deficiency
Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function.
steroid 11beta-monooxygenase deficiency
Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia: detection by ultrasonography.
steroid 11beta-monooxygenase deficiency
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Testicular enlargement in patients with 11-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
steroid 11beta-monooxygenase deficiency
The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome.
steroid 11beta-monooxygenase deficiency
The natural history of salt-wasting disorders of adrenal and renal origin.
steroid 11beta-monooxygenase deficiency
The prevalence of late onset congenital adrenal hyperplasia in hirsute women from Central Anatolia.
steroid 11beta-monooxygenase deficiency
The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population.
steroid 11beta-monooxygenase deficiency
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
steroid 11beta-monooxygenase deficiency
The steroid metabolite 16(?)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.
steroid 11beta-monooxygenase deficiency
The steroid response to controlled adrenal stimulation in congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
The value of low dose (1 microg) ACTH stimulation test in the investigation of non-classic adrenal hyperplasia due to 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Three novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11Beta-hydroxylase deficiency in a moroccan population.
steroid 11beta-monooxygenase deficiency
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
steroid 11beta-monooxygenase deficiency
Triple-x syndrome accompanied by congenital adrenal hyperplasia: case report.
steroid 11beta-monooxygenase deficiency
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Two novel mutations of the CYP11B2 gene in a Japanese patient with aldosterone deficiency type 1.
steroid 11beta-monooxygenase deficiency
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
steroid 11beta-monooxygenase deficiency
Type 1 aldosterone synthase deficiency presenting in a middle-aged man.
steroid 11beta-monooxygenase deficiency
Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia.
steroid 11beta-monooxygenase deficiency
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
steroid 11beta-monooxygenase deficiency
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
steroid 11beta-monooxygenase deficiency
X-linked adrenal hypoplasia congenita caused by a novel intronic mutation of the DAX-1 gene.
steroid 11beta-monooxygenase deficiency
[11 beta hydroxylase deficiency: a clinical study of seven cases]
steroid 11beta-monooxygenase deficiency
[11 beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[11-beta-hydroxylase deficiency and glucocorticoid-sensitive hyperaldosteronism]
steroid 11beta-monooxygenase deficiency
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
steroid 11beta-monooxygenase deficiency
[11beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[11Beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[Adrenal enzymatic block with late-onset caused by 11-hydroxylase deficiency. Apropos of 29 cases]
steroid 11beta-monooxygenase deficiency
[Aldosterone synthase deficiency]
steroid 11beta-monooxygenase deficiency
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[Clinical and genetic analysis of an infant with aldosterone synthase deficiency].
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency. A case report]
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency - different HLA genotypes in 2 brothers]
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia. Presentation of a case and review of the literature]
steroid 11beta-monooxygenase deficiency
[Congenital adrenal hyperplasia]
steroid 11beta-monooxygenase deficiency
[Congenital virilizing adrenal hyperplasia due to 11 beta-hydroxylase deficiency. Study of eleven cases (author's transl)]
steroid 11beta-monooxygenase deficiency
[Defects of adrenal steroidogenesis in patients with hirsutism]
steroid 11beta-monooxygenase deficiency
[Diagnosis of the adrenogenital syndrome caused by 11beta-hydroxylase deficiency using gas chromatographic-mass spectrometric analysis of the urinary steroid profile]
steroid 11beta-monooxygenase deficiency
[Endocrine and neurogenic hypertension in childhood]
steroid 11beta-monooxygenase deficiency
[Familial congenital adrenal hyperplasia caused by 11 beta-hydroxylase. Failure of prevention of sexual ambiguity and prenatal diagnosis]
steroid 11beta-monooxygenase deficiency
[Four cases of aldosterone synthase deficiency in childhood].
steroid 11beta-monooxygenase deficiency
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
steroid 11beta-monooxygenase deficiency
[Late diagnosis hyperandrogenism due to adrenal enzyme deficiency (author's transl)]
steroid 11beta-monooxygenase deficiency
[Molecular genetic verification of isolated mineralocorticoid deficiency due to aldosterone synthase deficiency].
steroid 11beta-monooxygenase deficiency
[Partial 3-beta-hydroxysteroid dehydrogenase deficiencies]
steroid 11beta-monooxygenase deficiency
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
steroid 11beta-monooxygenase deficiency
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
steroid 11beta-monooxygenase deficiency
[Rare forms of female pseudohermaphroditism: when to investigate?]
steroid 11beta-monooxygenase deficiency
[Severe form of congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency in a 3-year old boy]
steroid 11beta-monooxygenase deficiency
[Treatment of male adrenogenital syndrome (report of 17 cases)]
steroid 11beta-monooxygenase deficiency
[Variations of production rate of cortisol, corticosterone, aldosterone and desoxycorticosterone in 4 cases of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency]
steroid 17alpha-monooxygenase deficiency
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
steroid 21-monooxygenase deficiency
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
steroid 21-monooxygenase deficiency
15 beta-hydroxylated steroids may be diagnostically misleading in confirming congenital adrenal hyperplasia suspected by a newborn screening programme.
steroid 21-monooxygenase deficiency
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
21-hydroxylase deficiency transiently mimicking combined 21- and 11beta-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
steroid 21-monooxygenase deficiency
A detailed investigation of hirsutism in a Turkish population: idiopathic hyperandrogenemia as a perplexing issue.
steroid 21-monooxygenase deficiency
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
steroid 21-monooxygenase deficiency
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
steroid 21-monooxygenase deficiency
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
steroid 21-monooxygenase deficiency
Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche.
steroid 21-monooxygenase deficiency
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.
steroid 21-monooxygenase deficiency
Benign testicular tumors in children with congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Bone turnover and bone mineral density in patients with congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia family studies using the short ACTH test.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia in pregnancy.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia in Sweden 1969-1986. Prevalence, symptoms and age at diagnosis.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
steroid 21-monooxygenase deficiency
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
steroid 21-monooxygenase deficiency
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Effect of hydrocortisone dose schedule on adrenal steroid secretion in congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Effects of fetal androgen on childhood behavior.
steroid 21-monooxygenase deficiency
Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia.
steroid 21-monooxygenase deficiency
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Late-onset congenital adrenal hyperplasia in women with hirsutism.
steroid 21-monooxygenase deficiency
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
steroid 21-monooxygenase deficiency
Molecular genetics of congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
steroid 21-monooxygenase deficiency
Prenatal treatment of congenital adrenal hyperplasia. The United States experience.
steroid 21-monooxygenase deficiency
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients.
steroid 21-monooxygenase deficiency
Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function.
steroid 21-monooxygenase deficiency
Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia: detection by ultrasonography.
steroid 21-monooxygenase deficiency
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
steroid 21-monooxygenase deficiency
The steroid response to controlled adrenal stimulation in congenital adrenal hyperplasia.
steroid 21-monooxygenase deficiency
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
steroid 21-monooxygenase deficiency
[Results of genitoplasty for virilized genitalia of 41 females with congenital adrenal hyperplasia]
steroid 21-monooxygenase deficiency
[Treatment of male adrenogenital syndrome (report of 17 cases)]
Stroke
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
Stroke
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Stroke
Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension.
Stroke
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Stroke
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Stroke
Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis.
Stroke
The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis.
Testicular Neoplasms
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
Testicular Neoplasms
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Tuberous Sclerosis
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Ventricular Dysfunction, Left
Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart.
Ventricular Dysfunction, Left
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0000016
(R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Homo sapiens
competitive inhibition, pH 7.4
0.0000024
(1R)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000003
(1S)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000099
(R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Homo sapiens
competitive inhibition, pH 7.4, 25°C
0.000448
1-(1H-inden-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B2 IC50: 448 nM, no inhibition of CYP11B1, recombinant enzymes
0.000334 - 0.000639
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole
0.000143 - 0.000365
1-(3-bromobenzyl)-1H-imidazole
0.000151 - 0.000457
1-(3-chlorobenzyl)-1H-imidazole
0.001
1-(3-cyanobenzyl)-1H-imidazole
0.000206 - 0.000815
1-(3-fluorobenzyl)-1H-imidazole
0.000236 - 0.001
1-(4-aminobenzyl)-1H-imidazole
0.000211 - 0.000479
1-(4-bromobenzyl)-1H-imidazole
0.0000051 - 0.000007
1-(4-bromobenzyl)-5-phenyl-1H-imidazole
0.001
1-(4-chlorobenzyl)-1H-imidazole
0.0000058 - 0.000025
1-(4-chlorobenzyl)-5-phenyl-1H-imidazole
0.000368 - 0.000372
1-(4-cyanobenzyl)-1H-imidazole
0.0000023 - 0.00002
1-(4-cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole
0.0000037 - 0.0000057
1-(4-cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole
0.0000055 - 0.000032
1-(4-cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole
0.0000052 - 0.0000062
1-(4-cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole
0.000025 - 0.000027
1-(4-cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole
0.000117 - 0.00013
1-(4-cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole
0.000307 - 0.000407
1-(4-cyanobenzyl)-5-(4-pyridyl)-1H-imidazole
0.000007 - 0.000048
1-(4-cyanobenzyl)-5-(methyl carboxylate)-1H-imidazole
0.000044 - 0.000213
1-(4-cyanobenzyl)-5-(methylene-acetate)-1H-imidazole
0.000023 - 0.000073
1-(4-cyanobenzyl)-5-bromo-1H-imidazole
0.000062 - 0.000478
1-(4-cyanobenzyl)-5-formyl-1H-imidazole
0.000029 - 0.000285
1-(4-cyanobenzyl)-5-hydroxymethyl-1H-imidazole
0.000012 - 0.000141
1-(4-cyanobenzyl)-5-methyl-1H-imidazole
0.0000017 - 0.000028
1-(4-cyanobenzyl)-5-phenyl-1H-imidazole
0.00033 - 0.001799
1-(4-fluorobenzyl)-1H-imidazole
0.000011 - 0.000016
1-(4-fluorobenzyl)-5-phenyl-1H-imidazole
0.000011 - 0.000014
1-(4-methoxybenzyl)-5-phenyl-1H-imidazole
0.000411 - 0.000763
1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole
0.0000048 - 0.000011
1-benzyl-5-phenyl-1H-imidazole
0.0000161 - 0.000166
2,4,5-trifluoro-N-(pyridin-3-yl)benzamide
0.0000052
2-(4-chlorobenzyl)-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000186
2-benzyl-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000094
2-[(1R)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000617
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000007
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(3-methoxy-2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000013
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(cyclopropylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000078
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(3-methyloxetan-3-yl)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000008
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(propan-2-yloxy)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000059 - 0.0000535
3,4-difluoro-N-(pyridin-3-yl)benzamide
0.000181 - 0.000286
3-(1-benzyl-1H-imidazol-5-yl)-1-propanol
0.00003 - 0.002117
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine
0.000007 - 0.001268
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine
0.00039 - 0.0006
3-(1H-imidazol-1-ylmethyl)aniline
0.000007 - 0.001729
3-(3,4-dihydronaphthalen-2-yl)pyridine
0.000005 - 0.000503
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000176 - 0.001615
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000013 - 0.001291
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000004 - 0.005684
3-(6-methoxy-1H-inden-2-yl)pyridine
0.000002 - 0.000578
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
0.000045
3-(7-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 45 nM, no inhibition of CYP11B1, recombinant enzymes
0.000288 - 0.000735
3-[(Z)-2-phenylvinyl]pyridine
0.0000062 - 0.000018
3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000044 - 0.000055
3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000013 - 0.000048
3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000016 - 0.000116
3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000012 - 0.000059
3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-1-propanol
0.0000114
3-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-2-methylpropan-1-ol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000005 - 0.0000017
4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile
0.000117
4-(2-methylpropyl)-2-(thiophen-2-ylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000104
4-(2-methylpropyl)-2-[4-(trifluoromethoxy)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000121
4-(2-methylpropyl)-2-[4-(trifluoromethyl)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.002529 - 0.002834
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
0.000104 - 0.000167
4-bromo-N-(pyridin-3-yl)benzamide
0.0000102 - 0.000065
4-chloro-N-(pyridin-3-yl)benzamide
0.0000075 - 0.000078
4-cyano-N-(pyridin-3-yl)benzamide
0.0000143 - 0.000082
4-fluoro-N-(pyridin-3-yl)benzamide
0.0000248 - 0.000145
4-nitro-N-(pyridin-3-yl)benzamide
0.0000002 - 0.000033
6-(5,8-dihydroisoquinolin-4-yl)-3,4-dihydroquinolin-2(1H)-one
0.000089 - 0.002077
8-(1H-imidazol-1-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000001 - 0.000158
8-(5-ethoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000044 - 0.001288
8-(5-fluoropyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000043 - 0.002045
8-(5-hydroxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000006 - 0.000247
8-(5-methoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000013 - 0.000058
8-(5-phenylpyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]-quinolin-4-one
0.0000002 - 0.000013
8-(isoquinolin-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000011 - 0.000715
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000012 - 0.000333
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-thione
0.000056 - 0.02855
8-(pyrimidin-5-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000036 - 0.000183
8-[5-(2,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000007 - 0.000043
8-[5-(2-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000024 - 0.000128
8-[5-(2-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000023 - 0.000496
8-[5-(3,4-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000018 - 0.001748
8-[5-(3,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000014 - 0.00049
8-[5-(3-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000012 - 0.000044
8-[5-(3-hydroxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000046 - 0.001374
8-[5-(3-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000009 - 0.00004
8-[5-(4-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000014 - 0.000021
8-[5-(4-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000022 - 0.000103
8-[5-(propan-2-yloxy)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000059 - 0.000141
8-[5-(trifluoromethyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000016 - 0.002058
8-[5-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000033 - 0.004646
8-[5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000009 - 0.000545
9-(5-methoxypyridin-3-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
0.0000024 - 0.002296
9-(pyridin-3-yl)-1,2,6,7-tetrahydro-5H-pyrido[ 3,2,1-ij]quinolin-3-one
0.0000002 - 0.000034
9-[6-(isoquinolin-4-yl)pyridin-3-yl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
0.000001 - 0.00001
fadrozole
0.000081 - 0.000224
ketoconazole
0.000193 - 0.000326
methyl 3-(1-benzyl-1H-imidazol-5-yl)-propanoate
0.000004 - 0.000057
methyl 3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-propanoate
0.000123 - 0.000177
methyl 3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-propanoate
0.0000035 - 0.000031
methyl 3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-propanoate
0.00005 - 0.000104
methyl 3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-propanoate
0.000111 - 0.000121
methyl 3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-propanoate
0.0000146 - 0.000072
Metyrapone
0.000006 - 0.000119
R-fadrozole
0.00004 - 0.000171
S-fadrozole
0.000206 - 0.001174
[3-(1H-imidazol-1-ylmethyl)phenyl]methanol
0.000695 - 0.001
[4-(1H-imidazol-1-ylmethyl)phenyl]methanol
0.0001
additional information
Homo sapiens
-
development and analysis of inhibitory potency of diverse inhibitors by superimposition of active and non-active compounds, modelling based on two pyridyl substituted acenaphthene derivatives, IC50 values of good inhibitors below 100 nM and of weak inhibi
-
0.000334
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B2 IC50: 334 nM, recombinant enzymes
0.000639
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B1 IC50: 639 nM
0.000143
1-(3-bromobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000365
1-(3-bromobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000151
1-(3-chlorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000457
1-(3-chlorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.001
1-(3-cyanobenzyl)-1H-imidazole
Homo sapiens
-
above, inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001
1-(3-cyanobenzyl)-1H-imidazole
Homo sapiens
-
above, inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000206
1-(3-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000815
1-(3-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000236
1-(4-aminobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001
1-(4-aminobenzyl)-1H-imidazole
Homo sapiens
-
above, inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000211
1-(4-bromobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000479
1-(4-bromobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000051
1-(4-bromobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000007
1-(4-bromobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001
1-(4-chlorobenzyl)-1H-imidazole
Homo sapiens
-
above, inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001
1-(4-chlorobenzyl)-1H-imidazole
Homo sapiens
-
above, inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000058
1-(4-chlorobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000025
1-(4-chlorobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000368
1-(4-cyanobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000372
1-(4-cyanobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000023
1-(4-cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.00002
1-(4-cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0000037
1-(4-cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000057
1-(4-cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0000055
1-(4-cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000032
1-(4-cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0000052
1-(4-cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000062
1-(4-cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000025
1-(4-cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000027
1-(4-cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000117
1-(4-cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.00013
1-(4-cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000307
1-(4-cyanobenzyl)-5-(4-pyridyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000407
1-(4-cyanobenzyl)-5-(4-pyridyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000007
1-(4-cyanobenzyl)-5-(methyl carboxylate)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000048
1-(4-cyanobenzyl)-5-(methyl carboxylate)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000044
1-(4-cyanobenzyl)-5-(methylene-acetate)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000213
1-(4-cyanobenzyl)-5-(methylene-acetate)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000023
1-(4-cyanobenzyl)-5-bromo-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000073
1-(4-cyanobenzyl)-5-bromo-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000062
1-(4-cyanobenzyl)-5-formyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000478
1-(4-cyanobenzyl)-5-formyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000029
1-(4-cyanobenzyl)-5-hydroxymethyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000285
1-(4-cyanobenzyl)-5-hydroxymethyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000012
1-(4-cyanobenzyl)-5-methyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000141
1-(4-cyanobenzyl)-5-methyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0000017
1-(4-cyanobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000028
1-(4-cyanobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.00033
1-(4-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000494
1-(4-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000709
1-(4-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001799
1-(4-fluorobenzyl)-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000011
1-(4-fluorobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000016
1-(4-fluorobenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000011
1-(4-methoxybenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000014
1-(4-methoxybenzyl)-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000411
1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B2 IC50: 411 nM, recombinant enzymes
0.000763
1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B1 IC50: 763 nM
0.0000048
1-benzyl-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000011
1-benzyl-5-phenyl-1H-imidazole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000161
2,4,5-trifluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000166
2,4,5-trifluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000059
3,4-difluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000535
3,4-difluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000181
3-(1-benzyl-1H-imidazol-5-yl)-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000286
3-(1-benzyl-1H-imidazol-5-yl)-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.00003
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine
Homo sapiens
-
CYP11B2 IC50: 30 nM, recombinant enzymes
0.002117
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine
Homo sapiens
-
CYP11B1 IC50: 2117 nM
0.000007
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine
Homo sapiens
-
CYP11B2 IC50: 7 nM, recombinant enzymes
0.001268
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine
Homo sapiens
-
CYP11B1 IC50: 1268 nM
0.00039
3-(1H-imidazol-1-ylmethyl)aniline
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0006
3-(1H-imidazol-1-ylmethyl)aniline
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000007
3-(3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 7 nM, recombinant enzymes
0.001729
3-(3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B1 IC50: 1729 nM
0.000005
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 5 nM, recombinant enzymes
0.000503
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B1 IC50: 503 nM
0.000176
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 176 nM, recombinant enzymes
0.001615
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B1 IC50: 1615 nM
0.000013
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
, CYP11B2 IC50: 13 nM, recombinant enzymes
0.001291
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B1 IC50: 1291 nM
0.000004
3-(6-methoxy-1H-inden-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 4 nM, recombinant enzymes
0.005684
3-(6-methoxy-1H-inden-2-yl)pyridine
Homo sapiens
-
competitive, CYP11B1 IC50: 5684 nM
0.000002
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 2 nM, recombinant enzymes
0.000578
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
competitive, CYP11B1 IC50: 578 nM
0.000288
3-[(Z)-2-phenylvinyl]pyridine
Homo sapiens
-
CYP11B1 IC50: 288 nM
0.000735
3-[(Z)-2-phenylvinyl]pyridine
Homo sapiens
-
CYP11B2 IC50: 735 nM, no inhibition by the 3-[(E)-2-phenylvinyl]pyridine isomer, recombinant enzymes
0.0000062
3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000018
3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000044
3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000055
3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000013
3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000048
3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000016
3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000116
3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000012
3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000059
3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-1-propanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000005
4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.0000017
4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.002529
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B1 IC50: 2529 nM
0.002834
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 2834 nM, recombinant enzymes
0.000104
4-bromo-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000167
4-bromo-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000102
4-chloro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000065
4-chloro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000075
4-cyano-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000078
4-cyano-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000143
4-fluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000082
4-fluoro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000248
4-nitro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000145
4-nitro-N-(pyridin-3-yl)benzamide
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.0000002
6-(5,8-dihydroisoquinolin-4-yl)-3,4-dihydroquinolin-2(1H)-one
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000033
6-(5,8-dihydroisoquinolin-4-yl)-3,4-dihydroquinolin-2(1H)-one
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000089
8-(1H-imidazol-1-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.002077
8-(1H-imidazol-1-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000001
8-(5-ethoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000158
8-(5-ethoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000044
8-(5-fluoropyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001288
8-(5-fluoropyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000043
8-(5-hydroxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.002045
8-(5-hydroxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000006
8-(5-methoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000247
8-(5-methoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000013
8-(5-phenylpyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]-quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000058
8-(5-phenylpyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]-quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000002
8-(isoquinolin-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000013
8-(isoquinolin-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000011
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000715
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000012
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-thione
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000333
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-thione
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000056
8-(pyrimidin-5-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.02855
8-(pyrimidin-5-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000036
8-[5-(2,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000183
8-[5-(2,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000007
8-[5-(2-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000043
8-[5-(2-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000024
8-[5-(2-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000128
8-[5-(2-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000023
8-[5-(3,4-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000496
8-[5-(3,4-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000018
8-[5-(3,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001748
8-[5-(3,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000014
8-[5-(3-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.00049
8-[5-(3-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000012
8-[5-(3-hydroxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000044
8-[5-(3-hydroxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000046
8-[5-(3-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001374
8-[5-(3-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000009
8-[5-(4-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.00004
8-[5-(4-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000014
8-[5-(4-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000021
8-[5-(4-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000022
8-[5-(propan-2-yloxy)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000103
8-[5-(propan-2-yloxy)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000059
8-[5-(trifluoromethyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000141
8-[5-(trifluoromethyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000016
8-[5-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.002058
8-[5-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000033
8-[5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.004646
8-[5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000009
9-(5-methoxypyridin-3-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000545
9-(5-methoxypyridin-3-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000024
9-(pyridin-3-yl)-1,2,6,7-tetrahydro-5H-pyrido[ 3,2,1-ij]quinolin-3-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.002296
9-(pyridin-3-yl)-1,2,6,7-tetrahydro-5H-pyrido[ 3,2,1-ij]quinolin-3-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000002
9-[6-(isoquinolin-4-yl)pyridin-3-yl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000034
9-[6-(isoquinolin-4-yl)pyridin-3-yl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000001
fadrozole
Homo sapiens
-
CYP11B2 IC50: 1 nM
0.00001
fadrozole
Homo sapiens
-
CYP11B1 IC50: 10 nM, recombinant enzymes
0.000081
ketoconazole
Homo sapiens
-
CYP11B2 IC50: 81 nM
0.000224
ketoconazole
Homo sapiens
-
IC50 CYP11B1 IC50: 224 nM, recombinant enzymes
0.000193
methyl 3-(1-benzyl-1H-imidazol-5-yl)-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000326
methyl 3-(1-benzyl-1H-imidazol-5-yl)-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000004
methyl 3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000057
methyl 3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000123
methyl 3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000177
methyl 3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000035
methyl 3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000031
methyl 3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.00005
methyl 3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000104
methyl 3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000111
methyl 3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000121
methyl 3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-propanoate
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000146
Metyrapone
Homo sapiens
-
inhibition of CYP11B1, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000072
Metyrapone
Homo sapiens
-
inhibition of CYP11B2, substrate 11-deoxycorticosterone, pH not specified in the publication, temperature not specified in the publication
0.000006
R-fadrozole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000119
R-fadrozole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.00004
S-fadrozole
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.000171
S-fadrozole
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000206
[3-(1H-imidazol-1-ylmethyl)phenyl]methanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001174
[3-(1H-imidazol-1-ylmethyl)phenyl]methanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000695
[4-(1H-imidazol-1-ylmethyl)phenyl]methanol
Homo sapiens
-
inhibition of CYP11B1, pH not specified in the publication, temperature not specified in the publication
0.001
[4-(1H-imidazol-1-ylmethyl)phenyl]methanol
Homo sapiens
-
above, inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.14.15.4 steroid 11beta-monooxygenase
more
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
