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beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
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beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
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Infections
Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.
Infections
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
Tuberculosis
Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 in Mycobacterium tuberculosis.
Tuberculosis
Identification of Novel Mutations in LprG (rv1411c), rv0521, rv3630, rv0010c, ppsC, and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis.
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physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
physiological function
Cyp128 is the enzyme responsible for the terminal oxidation of the polyisoprenoid chain of dihydromenaquinone-9, thereby allowing sulfation of the resulting hydroxyl moiety by Stf3. The sulfated metabolite S881 is associated with virulence in Mycobacterium tuberculosis
physiological function
-
the enzyme is involved in synthesis of electron transport molecules such as menaquinone-9 (MK9)
physiological function
-
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
-
physiological function
-
Cyp128 is the enzyme responsible for the terminal oxidation of the polyisoprenoid chain of dihydromenaquinone-9, thereby allowing sulfation of the resulting hydroxyl moiety by Stf3. The sulfated metabolite S881 is associated with virulence in Mycobacterium tuberculosis
-
physiological function
-
the enzyme is involved in synthesis of electron transport molecules such as menaquinone-9 (MK9)
-
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Holsclaw, C.; Sogi, K.; Gilmore, S.; Schelle, M.; Leavell, M.; Bertozzi, C.; Leary, J.
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis
ACS Chem. Biol.
3
619-624
2008
Mycobacterium tuberculosis (P9WPN7), Mycobacterium tuberculosis H37Rv (P9WPN7)
brenda
Sogi, K.M.; Holsclaw, C.M.; Fragiadakis, G.K.; Nomura, D.K.; Leary, J.A.; Bertozzi, C.R.
Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis
ACS Infect. Dis.
2
800-806
2016
Mycobacterium tuberculosis (P9WPN7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPN7)
brenda
Shi, W.; Chen, J.; Zhang, S.; Zhang, W.; Zhang, Y.
Identification of novel mutations in LprG (rv1411c), rv0521, rv3630, rv0010c, ppsC, and cyp128 associated with pyrazinoic acid/pyrazinamide resistance in Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
62
e00430-18
2018
Mycobacterium tuberculosis, Mycobacterium tuberculosis 3H4
brenda
Ngcobo, N.S.; Chiliza, Z.E.; Chen, W.; Yu, J.H.; Nelson, D.R.; Tuszynski, J.A.; Preto, J.; Syed, K.
Comparative analysis, structural insights, and substrate/drug interaction of CYP128A1 in Mycobacterium tuberculosis
Int. J. Mol. Sci.
21
4816
2020
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
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