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Information on EC 1.14.15.25 - p-cymene methyl-monooxygenase

for references in articles please use BRENDA:EC1.14.15.25
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IUBMB Comments
The enzyme, characterized from several Pseudomonas strains, initiates p-cymene catabolism through hydroxylation of the methyl group. The enzyme has a distinct preference for substrates containing at least an alkyl or heteroatom substituent at the para-position of toluene. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. In Pseudomonas chlororaphis the presence of a third component of unknown function greatly increases the activity. cf. EC 1.14.15.26, toluene methyl-monooxygenase.
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The expected taxonomic range for this enzyme is: Pseudomonas
Reaction Schemes
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+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
=
+
2
oxidized ferredoxin [iron-sulfur] cluster
+
Synonyms
cymA, cymAa, CymB, CymM, p-cymene methyl hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
p-cymene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 4-isopropylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
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