Reference on EC 1.14.15.24 - beta-carotene 3-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, I.J.; Ko, K.C.; Nam, T.S.; Kim, Y.W.; Chung, W.I.; Kim, C.S.
Expression and activity of citrus phytoene synthase and beta-carotene hydroxylase in Escherichia coli
J. Microbiol.
41
212-218
2003
Pantoea ananatis
-
Alvarez, V.; Rodriguez-Saiz, M.; de la Fuente, J.L.; Gudina, E.J.; Godio, R.P.; Martin, J.F.; Barredo, J.L.
The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls
Fungal Genet. Biol.
43
261-272
2006
Phaffia rhodozyma, Phaffia rhodozyma VKPM Y2410
Blasco, F.; Kauffmann, I.; Schmid, R.
CYP175A1 from Thermus thermophilus HB27, the first beta-carotene hydroxylase of the P450 superfamily
Appl. Microbiol. Biotechnol.
64
671-674
2004
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Choi, S.; Matsuda, S.; Hoshino, T.; Peng, X.; Misawa, N.
Characterization of bacterial beta-carotene 3,3-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli
Appl. Microbiol. Biotechnol.
72
1238-1246
2006
Pantoea ananatis (P21688), Pantoea ananatis, Paracoccus sp. (P54973), Paracoccus sp. (Q44262), Brevundimonas sp. (Q4W8B0), marine bacterium P99-3 (Q7WT73), marine bacterium P99-3, Brevundimonas sp. SD212 (Q4W8B0)
Tian, L.; DellaPenna, D.
Progress in understanding the origin and functions of carotenoid hydroxylases in plants
Arch. Biochem. Biophys.
430
22-29
2004
Arabidopsis thaliana (Q9SZZ8)
Momoi, K.; Hofmann, U.; Schmid, R.; Urlacher, V.
Reconstitution of beta-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase
Biochem. Biophys. Res. Commun.
339
331-336
2006
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Bouvier, F.; Keller, Y.; DHarlingue, A.; Camara, B.
Xanthophyll biosynthesis: Molecular and functional characterization of carotenoid hydroxylases from pepper fruits (Capsicum annuum L.)
Biochim. Biophys. Acta
1391
320-328
1998
Capsicum annuum (O49814)
Linden, H.
Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation
Biochim. Biophys. Acta
1446
203-212
1999
Haematococcus lacustris (Q9SPK6), Haematococcus lacustris, Haematococcus lacustris Flotow NIES-144 (Q9SPK6)
Zhu, C.; Yamamura, S.; Nishihara, M.; Koiwa, H.; Sandmann, G.
cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development
Biochim. Biophys. Acta
1625
305-308
2003
Gentiana lutea (B3SGL0), Gentiana lutea
Fraser, P.D.; Shimada, H.; Misawa, N.
Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay
Eur. J. Biochem.
252
229-236
1998
Agrobacterium aurantiacum
Hundle, B.; OBrien, D.; Beyer, P.; Kleining, H.; Hearst, J.
In vitro expression and activity of lycopene cyclase and beta-carotene hydroxylase from Erwinia herbicola
FEBS Lett.
315
329-334
1993
Pantoea agglomerans
Fiore, A.; DallOsto, L.; Fraser, P.; Bassi, R.; Giuliano, G.
Elucidation of the beta-carotene hydroxylation pathway in Arabidopsis thaliana
FEBS Lett.
580
4718-4722
2006
Arabidopsis thaliana
Sun, Z.; Gantt, E.; Cunningham, F.X.
Cloning and functional analysis of the beta-carotene hydroxylase of Arabidopsis thaliana
J. Biol. Chem.
271
24349-24352
1996
Arabidopsis thaliana (Q9SZZ8), Arabidopsis thaliana
Fraser, P.D.; Miura, Y.; Misawa, N.
In vitro characterization of astaxanthin biosynthetic enzymes
J. Biol. Chem.
272
6128-6135
1997
Alcaligenes sp., Pantoea ananatis, Agrobacterium aurantiacum
Deog, H.; Yu, J.; Choi, C.; Lee, H.; Park, J.; Dane, F.; Kang, K.
Astaxanthin production in transgenic Arabidopsis with chyB gene encoding beta-carotene hydroxylase
J. Plant Biol.
51
58-63
2008
Arabidopsis thaliana (Q9LTG0)
-
Ojima, K.; Breitenbach, J.; Visser, H.; Setoguchi, Y.; Tabata, K.; Hoshino, T.; van den Berg, J.; Sandmann, G.
Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase
Mol. Genet. Genomics
275
148-158
2006
Phaffia rhodozyma, Phaffia rhodozyma ATCC 96594
Davison, P.; Hunter, C.; Horton, P.
Overexpression of beta-carotene hydroxylase enhances stress tolerance in Arabidopsis
Nature
418
203-206
2002
Arabidopsis thaliana (Q9SZZ8), Arabidopsis thaliana
Rissler, H.M.; Pogson, B.J.
Antisense inhibition of the beta-carotene hydroxylase enzyme in Arabidopsis and the implications for carotenoid accumulation, photoprotection and antenna assembly
Photosynth. Res.
67
127-137
2001
Arabidopsis thaliana (Q9SZZ8), Arabidopsis thaliana
Kim, J.; Cheng, K.; Craft, N.; Hamberger, B.; Douglas, C.
Over-expression of Arabidopsis thaliana carotenoid hydroxylases individually and in combination with a beta-carotene ketolase provides insight into in vivo functions
Phytochemistry
71
168-178
2010
Arabidopsis thaliana
Kim, J.; Smith, J.; Tian, L.; DellaPenna, D.
The evolution and function of carotenoid hydroxylases in Arabidopsis
Plant Cell Physiol.
50
463-479
2009
Arabidopsis thaliana
Tian, L.; Magallanes-Lundback, M.; Musetti, V.; DellaPenna, D.
Functional analysis of beta- and epsilon-ring carotenoid hydroxylases in Arabidopsis
Plant Cell
15
1320-1332
2003
Arabidopsis thaliana (Q9LTG0), Arabidopsis thaliana (Q9SZZ8)
Steinbrenner, J.; Linden, H.
Regulation of two carotenoid biosynthesis genes coding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis
Plant Physiol.
125
810-817
2001
Haematococcus lacustris, Haematococcus lacustris Flotow NIES-144
Du, H.; Wang, N.; Cui, F.; Li, X.; Xiao, J.; Xiong, L.
Characterization of the beta-carotene hydroxylase gene DSM2 conferring drought and oxidative stress resistance by increasing xanthophylls and abscisic acid synthesis in rice
Plant Physiol.
154
1304-1318
2010
Oryza sativa
Kim, I.; Ko, K.; Kim, C.; Chung, W.
Isolation and characterization of cDNAs encoding beta-carotene hydroxylase in Citrus
Plant Sci.
161
1005-1010
2001
Citrus unshiu (Q9FUB9), Citrus unshiu (Q9FUN2)
-
Yu, B.; Lydiate, D.; Schfer, U.; Hannoufa, A.
Characterization of a beta-carotene hydroxylase of Adonis aestivalis and its expression in Arabidopsis thaliana
Planta
226
181-192
2007
Adonis aestivalis
D'Ambrosio, C.; Stigliani, A.; Giorio, G.
Overexpression of CrtR-b2 (carotene beta hydroxylase 2) from S. lycopersicum L. differentially affects xanthophyll synthesis and accumulation in transgenic tomato plants
Transgenic Res.
20
47-60
2011
Solanum lycopersicum (Q0GGX1), Solanum lycopersicum
Inoue, K.
Carotenoid hydroxylation - P450 finally!
Trends Plant Sci.
9
515-517
2004
Arabidopsis thaliana
Scaife, M.A.; Ma, C.A.; Ninlayarn, T.; Wright, P.C.; Armenta, R.E.
Comparative analysis of ?-carotene hydroxylase genes for astaxanthin biosynthesis
J. Nat. Prod.
75
1117-1124
2012
Saccharolobus solfataricus (Q97UT7), Saccharolobus solfataricus P2 (Q97UT7)
Fiore, A.; DallOsto, L.; Cazzaniga, S.; Diretto, G.; Giuliano, G.; Bassi, R.
A quadruple mutant of Arabidopsis reveals a beta-carotene hydroxylation activity for LUT1/CYP97C1 and a regulatory role of xanthophylls on determination of the PSI/PSII ratio
BMC Plant Biol.
12
50
2012
Arabidopsis thaliana
Misawa, N.
Carotenoid beta-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls
Mar. Drugs
9
757-771
2011
Paracoccus sp., Brevundimonas sp., Brevundimonas sp. SD212
Kim, S.H.; Ahn, Y.O.; Ahn, M.J.; Lee, H.S.; Kwak, S.S.
Down-regulation of beta-carotene hydroxylase increases beta-carotene and total carotenoids enhancing salt stress tolerance in transgenic cultured cells of sweetpotato
Phytochemistry
74
69-78
2012
Ipomoea batatas (H6TBL3)
Lv, M.Z.; Chao, D.Y.; Shan, J.X.; Zhu, M.Z.; Shi, M.; Gao, J.P.; Lin, H.X.
Rice carotenoid beta-ring hydroxylase CYP97A4 is involved in lutein biosynthesis
Plant Cell Physiol.
53
987-1002
2012
Oryza sativa
Zhao, D.; Zhou, C.; Sheng, Y.; Liang, G.; Tao, J.
Molecular cloning and expression of phytoene synthase, lycopene beta-cyclase, and beta-carotene hydroxylase genes in persimmon (Diospyros kaki L.) fruits
Plant Mol. Biol. Rep.
29
345-351
2011
Diospyros kaki (C0LZJ0)
-
Quinlan, R.; Shumskaya, M.; Bradbury, L.; Beltran, J.; Ma, C.; Kennelly, E.; Wurtzel, E.
Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesis
Plant Physiol.
160
204-214
2012
Oryza sativa
Borovsky, Y.; Tadmor, Y.; Bar, E.; Meir, A.; Lewinsohn, E.; Paran, I.
Induced mutation in beta-CAROTENE HYDROXYLASE results in accumulation of beta-carotene and conversion of red to orange color in pepper fruit
Theor. Appl. Genet.
126
557-565
2013
Capsicum annuum (D7P8N7)
Zhou, P.; Xie, W.; Li, A.; Wang, F.; Yao, Z.; Bian, Q.; Zhu, Y.; Yu, H.; Ye, L.
Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae
Enzyme Microb. Technol.
100
28-36
2017
Haematococcus lacustris (Q9SPK6)
Wang, R.; Gu, X.; Yao, M.; Pan, C.; Liu, H.; Xiao, W.; Wang, Y.; Yuan, Y.
Engineering of beta-carotene hydroxylase and ketolase for astaxanthin overproduction in Saccharomyces cerevisiae
Front. Chem. Sci. Engin.
11
89-99
2017
Alcaligenes sp. PC-1, Alcaligenes sp. PC-1 (Q44262)
-
Lu, Q.; Bu, Y.F.; Liu, J.Z.
Metabolic engineering of Escherichia coli for producing astaxanthin as the predominant carotenoid
Mar. Drugs
15
E296
2017
Pantoea ananatis (D4GFL0)
Simon, D.; Anila, N.; Gayathri, K.; Sarada, R.
Heterologous expression of beta-carotene hydroxylase in Dunaliella salina by Agrobacterium-mediated genetic transformation
Algal Res.
18
257-265
2016
Chlamydomonas reinhardtii
-
Chang, J.; Thia, C.; Lin, H.; Liu, H.; Ho, F.; Wu, J.; Shih, M.; Li, W.; Huang, C.
Integrating an algal beta-carotene hydroxylase gene into a designed carotenoid-biosynthesis pathway increases carotenoid production in yeast
Biores. Technol.
184
2-8
2015
Chlamydomonas reinhardtii, Haematococcus lacustris, Chromochloris zofingiensis
Wu, J.; Ji, J.; Wang, G.; Li, Z.; Diao, J.; Wu, G.
Cloning and characterization of a novel beta-carotene hydroxylase gene from Lycium barbarum and its expression in Escherichia coli
Biotechnol. Appl. Biochem.
61
637-645
2014
Lycium barbarum (U5Y6R4)
Zhao, Q.; Wang, G.; Ji, J.; Jin, C.; Wu, W.; Zhao, J.
Over-expression of Arabidopsis thaliana beta-carotene hydroxylase (chyB) gene enhances drought tolerance in transgenic tobacco
J. Plant Biochem. Biotechnol.
23
190-198
2014
Arabidopsis thaliana
-
Choudhary, M.; Hossain, F.; Muthusamy, V.; Thirunavukkarasu, N.; Saha, S.; Pandey, N.; Jha, S.; Gupta, H.
Microsatellite marker-based genetic diversity analyses of novel maize inbreds possessing rare allele of beta-carotene hydroxylase (crtRB1) for their utilization in beta-carotene enrichment
J. Plant Biochem. Biotechnol.
25
12-20
2016
Zea mays
-
Henke, N.; Heider, S.; Peters-Wendisch, P.; Wendisch, V.
Production of the marine carotenoid astaxanthin by metabolically engineered Corynebacterium glutamicum
Mar. Drugs
14
124
2016
Fulvimarina pelagi
Zunjare, R.; Hossain, F.; Muthusamy, V.; Baveja, A.; Chauhan, H.; Thirunavukkarasu, N.; Saha, S.; Gupta, H.
Influence of rare alleles of beta-carotene hydroxylase and lycopene epsilon cyclase genes on accumulation of provitamin A carotenoids in maize kernels
Plant Breed.
136
872-880
2017
Zea mays
-
Wu, J.; Ji, J.; Wang, G.; Wu, G.; Diao, J.; Li, Z.; Chen, X.; Chen, Y.; Luo, L.
Ectopic expression of the Lycium barbarum beta-carotene hydroxylase gene (chyb) enhances drought and salt stress resistance by increasing xanthophyll cycle pool in tobacco
Plant Cell
121
559-569
2015
Lycium barbarum (U5Y6R4)
-
Kang, L.; Ji, C.Y.; Kim, S.H.; Ke, Q.; Park, S.C.; Kim, H.S.; Lee, H.U.; Lee, J.S.; Park, W.S.; Ahn, M.J.; Lee, H.S.; Deng, X.; Kwak, S.S.
Suppression of the beta-carotene hydroxylase gene increases beta-carotene content and tolerance to abiotic stress in transgenic sweetpotato plants
Plant Physiol. Biochem.
117
24-33
2017
Ipomoea batatas
Kilcrease, J.; Rodriguez-Uribe, L.; Richins, R.; Arcos, J.; Victorino, J.; O'Connell, M.
Correlations of carotenoid content and transcript abundances for fibrillin and carotenogenic enzymes in Capsicum annum fruit pericarp
Plant Sci.
232
57-66
2015
Capsicum annuum (D7P8N7)
Tao, L.; Rouviere, P.E.; Cheng, Q.
A carotenoid synthesis gene cluster from a non-marine Brevundimonas that synthesizes hydroxylated astaxanthin
Gene
379
101-108
2006
Brevundimonas vesicularis (Q0H2D7), Brevundimonas vesicularis DC2630 (Q0H2D7)
Martin, J.F.; Gudina, E.; Barredo, J.L.
Conversion of beta-carotene into astaxanthin Two separate enzymes or a bifunctional hydroxylase-ketolase protein?
Microb. Cell Fact.
7
3
2008
Phaffia rhodozyma, Phaffia rhodozyma ATCC 96815
Kildegaard, K.R.; Adiego-Perez, B.; Domenech Belda, D.; Khangura, J.K.; Holkenbrink, C.; Borodina, I.
Engineering of Yarrowia lipolytica for production of astaxanthin
Synth. Syst. Biotechnol.
2
287-294
2017
Pantoea ananatis (P21688)
Shindo, K.; Hasunuma, T.; Asagi, E.; Sano, A.; Hotta, E.; Minemura, N.; Miyake, C.; Maoka, T.; Misawa, N.
4-Ketoantheraxanthin, a novel carotenoid produced by the combination of the bacterial enzyme beta-carotene ketolase CrtW and endogenous carotenoid biosynthetic enzymes in higher plants
Tetrahedron Lett.
49
3294-3296
2008
Brevundimonas sp. NBRC 101024 (Q4W8B0)
-
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