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Information on EC 1.14.15.16 - vitamin D3 24-hydroxylase

for references in articles please use BRENDA:EC1.14.15.16

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IUBMB Comments

This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide
calcitriol
+
2
reduced adrenodoxin
+
2
H+
+
O2
=
calcitetrol
+
2
oxidized adrenodoxin
+
H2O
+
2
reduced adrenodoxin
+
2
+
=
+
2
+
calcidiol
+
2
reduced adrenodoxin
+
2
H+
+
O2
=
secalciferol
+
2
oxidized adrenodoxin
+
H2O
+
2
reduced adrenodoxin
+
2
+
=
+
2
+

Synonyms
24-hydroxylase, 24-ohase, 25-hydroxyvitamin d3-24-hydroxylase, 25-hydroxyvitamin d-24-hydroxylase, 24ohase, vitamin d 24-hydroxylase, vitamin d-24-hydroxylase, p450cc24, cytochrome p450 24a1, vitamin d3 24-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
(2)
-
-
-
calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
(1)
-
-
-
PATHWAY SOURCE
PATHWAYS