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Information on EC 1.14.15.14 - methyl-branched lipid omega-hydroxylase

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IUBMB Comments
The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme.
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Word Map
  • 1.14.15.14
  • phakic
  • collamer
  • acuity
  • uncorrected
  • visian
  • toric
  • astigmatism
  • diopters
  • staar
  • myopic
  • vault
  • keratoconus
  • hyperopic
  • monochloride
  • logmar
  • lasik
The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Reaction Schemes
+
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
=
+
+
2
oxidized ferredoxin [iron-sulfur] cluster
Synonyms
CYP124, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a methyl-branched lipid + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = an omega-hydroxy-methyl-branched lipid + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
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