Reference on EC 1.14.14.B11 - nicotine demethylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Siminszky, B.; Gavilano, L.; Bowen, S.W.; Dewey, R.E.
Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase
Proc. Natl. Acad. Sci. USA
102
14919-14924
2005
Nicotiana tabacum (Q38Q86), Nicotiana tabacum
Yamanaka, H.; Nakajima, M.; Fukami, T.; Sakai, H.; Nakamura, A.; Katoh, M.; Takamiya, M.; Aoki, Y.; Yokoi, T.
CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions
Drug Metab. Dispos.
33
1811-1818
2005
Homo sapiens
Gavilano, L.B.; Coleman, N.P.; Burnley, L.E.; Bowman, M.L.; Kalengamaliro, N.E.; Hayes, A.; Bush, L.; Siminszky, B.
Genetic engineering of Nicotiana tabacum for reduced nornicotine content
J. Agric. Food Chem.
54
9071-9078
2006
Nicotiana tabacum
Gavilano, L.B.; Coleman, N.P.; Bowen, S.W.; Siminszky, B.
Functional analysis of nicotine demethylase genes reveals insights into the evolution of modern tobacco
J. Biol. Chem.
282
249-256
2007
Nicotiana tabacum, Nicotiana tomentosiformis (A1YJE2), Nicotiana tomentosiformis (A1YJE3), Nicotiana tomentosiformis
Hao, D.; Yeoman, M.M.
Evidence in favor of an oxidative N-demethylation of nicotine to nornicotine in tobacco cell cultures
J. Plant Physiol.
152
420-426
1998
Nicotiana tabacum
-
Chakrabarti, M.; Meekins, K.M.; Gavilano, L.B.; Siminszky, B.
Inactivation of the cytochrome P450 gene CYP82E2 by degenerative mutations was a key event in the evolution of the alkaloid profile of modern tobacco
New Phytol.
175
565-574
2007
Nicotiana sylvestris (A7KMF3), Nicotiana sylvestris
Lewis, R.S.; Jack, A.M.; Morris, J.W.; Robert, V.J.; Gavilano, L.B.; Siminszky, B.; Bush, L.P.; Hayes, A.J.; Dewey, R.E.
RNA interference (RNAi)-induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves
Plant Biotechnol. J.
6
346-354
2008
Nicotiana tabacum
Gavilano, L.B.; Siminszky, B.
Isolation and characterization of the cytochrome P450 gene CYP82E5v2 that mediates nicotine to nornicotine conversion in the green leaves of tobacco
Plant Cell Physiol.
48
1567-1574
2007
Nicotiana tabacum (A9QNE6), Nicotiana tabacum
Xu, D.; Shen, Y.; Chappell, J.; Cui, M.; Nielsen, M.T.
Biochemical and molecular characterizations of nicotine demethylase in tobacco
Physiol. Plant.
129
307-319
2007
Nicotiana tabacum (Q38Q87)
Lian, J.; Wang, D.; Xie, J.
Data mining of nicotine demethylase genes in modern tobacoo
Adv. Mater. Res.
787
356-360
2013
Nicotiana tabacum
-
Cai, B.; Bush, L.
Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf
J. Agric. Food Chem.
60
11586-11591
2012
Nicotiana tabacum
Cai, B.; Siminszky, B.; Chappell, J.; Dewey, R.; Bush, L.
Enantioselective demethylation of nicotine as a mechanism for variable nornicotine composition in tobacco leaf
J. Biol. Chem.
287
42804-42811
2012
Nicotiana tabacum
Pakdeechanuan, P.; Teoh, S.; Shoji, T.; Hashimoto, T.
Non-functionalization of two CYP82E nicotine N-demethylase genes abolishes nornicotine formation in nicotiana langsdorffii
Plant Cell Physiol.
53
2038-2046
2012
Nicotiana alata (J7M2E3), Nicotiana alata (J7M5N9), Nicotiana alata (J7MB22), Nicotiana alata (J7MDR0), Nicotiana alata, Nicotiana langsdorffii (J7M8Q0), Nicotiana langsdorffii
Wang, S.; Yang, S.; An, B.; Wang, S.; Yin, Y.; Lu, Y.; Xu, Y.; Hao, D.
Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase
PLoS ONE
6
e23342
2011
Nicotiana tabacum
Liedschulte, V.; Schwaar, J.D.; Laparra, H.; Vuarnoz, A.; Philippon, B.; Bakaher, N.; Sierro, N.; Bovet, L.; Lang, G.; Goepfert, S.
Identification of CYP82E21 as a functional nicotine N-demethylase in tobacco flowers
Phytochemistry
131
9-16
2016
Nicotiana tabacum
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