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Information on EC 1.14.14.90 - isoflavone 2'-hydroxylase

for references in articles please use BRENDA:EC1.14.14.90
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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC 1.14.14.89, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.
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The enzyme appears in viruses and cellular organisms
Synonyms
AmI2'H, CYP Ge-3, CYP81E, CYP81E1, CYP81E11, CYP81E12, CYP81E13, CYP81E42, I2'H, isoflavone 2'-monooxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an isoflavone + [reduced NADPH-hemoprotein reductase] + O2 = a 2'-hydroxyisoflavone + [oxidized NADPH-hemoprotein reductase] + H2O
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