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Information on EC 1.14.14.81 - flavanoid 3',5'-hydroxylase

for references in articles please use BRENDA:EC1.14.14.81

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IUBMB Comments

A cytochrome P-450 (heme-thiolate) protein found in plants. The 3′,5′-dihydroxyflavanone is formed via the 3′-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4′-trihydroxyflavanone (naringenin) at either the 3′ position to form eriodictyol or at both the 3′ and 5′ positions to form 5,7,3′,4′,5′-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3′,4′-pentahydroxyflavanone (taxifolin) at the 5′ position, forming ampelopsin.

The enzyme appears in viruses and cellular organisms

Synonyms
f3'5'h, flavonoid 3',5'-hydroxylase, flavonoid 3'5'-hydroxylase, flavonoid 3'5' hydroxylase, cyp75a, cyp75a31, f3',5'h, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3'-hydroxyflavanone + [reduced NADPH-hemoprotein reductase] + O2 = a 3',5'-dihydroxyflavanone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1b)
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a flavanone + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = a 3',5'-dihydroxyflavanone + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
overall reaction
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a flavanone + [reduced NADPH-hemoprotein reductase] + O2 = a 3'-hydroxyflavanone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
flavonol biosynthesis