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IUBMB Comments This cytochrome P -450 (heme-thiolate) enzyme, found in Aspergillus nidulans , is involved in the degradation of phenylacetate.
Synonyms
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phenylacetate, NAD(P):oxygen oxidoreductase (2-hydroxylating)
PA 2-hydroxylase
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phaA
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phenylacetate, NAD(P):oxygen oxidoreductase (2-hydroxylating)
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phenylacetate, NAD(P):oxygen oxidoreductase (2-hydroxylating)
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phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 = (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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phenylacetate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)
This cytochrome P-450 (heme-thiolate) enzyme, found in Aspergillus nidulans, is involved in the degradation of phenylacetate.
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phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
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phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
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phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
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UniProt
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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malfunction
enzyme gene disruption results in increased penicillin production
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PHACA_EMEND
518
0
58495
Swiss-Prot
Mitochondrion (Reliability: 4 )
Q9URR6_PENCH
516
1
58072
TrEMBL
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L181F
the mutation is responsible for the reduced function of the enzyme
L181F
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the mutation is responsible for the reduced function of the enzyme
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gene transcription is strongly induced by phenylacetate
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Rodriguez-Saiz, M.; Barredo, J.L.; Moreno, M.A.; Fernandez-Canon, J.M.; Penalva, M.A.; Diez, B.
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains
J. Bacteriol.
183
5465-5471
2001
Penicillium chrysogenum (Q9URR6), Penicillium chrysogenum, Penicillium chrysogenum NRRL 1951 (Q9URR6)
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Mingot, J.; Pealva, M.; Fernandez-Canon, J.
Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction
J. Biol. Chem.
274
14545-14550
1999
Aspergillus nidulans (Q9Y7G5), Aspergillus nidulans
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