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Information on EC 1.14.14.3 - bacterial luciferase

for references in articles please use BRENDA:EC1.14.14.3

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IUBMB Comments

The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
luciferase, bacterial luciferase, luxab, luxcdabe, vibrio harveyi luciferase, vibrio fischeri luciferase, aldehyde monooxygenase, gluc luciferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + H2O + hnu
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
bacterial bioluminescence