Information on EC 1.14.14.177 - ultra-long-chain fatty acid omega-hydroxylase

for references in articles please use BRENDA:EC1.14.14.177
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IUBMB Comments
The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.
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The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms
CYP4F22, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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