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Information on EC 1.14.14.176 - taxadiene 5alpha-hydroxylase

for references in articles please use BRENDA:EC1.14.14.176

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IUBMB Comments

This microsomal cytochrome-P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.

The expected taxonomic range for this enzyme is: Taxus

Synonyms
cyp725a4, taxadiene 5alpha-hydroxylase, taxa-4(5),11(12)-diene 5alpha-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
taxol biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links