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Information on EC 1.14.14.175 - ferruginol synthase and Organism(s) Salvia fruticosa and UniProt Accession A0A0C5QRZ2

for references in articles please use BRENDA:EC1.14.14.175
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EC Tree
IUBMB Comments
A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
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This record set is specific for:
Salvia fruticosa
UNIPROT: A0A0C5QRZ2
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Word Map
The taxonomic range for the selected organisms is: Salvia fruticosa
The enzyme appears in selected viruses and cellular organisms
Synonyms
cyp76ah1, cyp76ah24, cyp76ah4, ferruginol synthase, miltiradiene oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CYP76AH1
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-
-
-
Cyp76AH22
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-
Cyp76AH23
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-
CYP76AH24
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-
SYSTEMATIC NAME
IUBMB Comments
abieta-8,11,13-triene,[reduced NADPH-hemoprotein reductase]:oxygen 12-oxidoreductase (ferruginol-forming)
A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2
ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
-
?
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2
ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
enzymes carry out not a single but two successive oxidations leading to 11-hydroxyferruginol from abieta-8,11,13-triene, i.e. reactions of EC 1.14.14.175 and 1.14.14.60
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
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-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
transient expression in Nicothiana benthamiana leads to synthese of ferruginol in leaf
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
C76H2_SALFT
492
0
55616
Swiss-Prot
Secretory Pathway (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Scheler, U.; Brandt, W.; Porzel, A.; Rothe, K.; Manzano, D.; Bozic, D.; Papaefthimiou, D.; Balcke, G.; Henning, A.; Lohse, S.; Marillonnet, S.; Kanellis, A.; Ferrer, A.; Tissier, A.
Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast
Nat. Commun.
7
12942
2016
Salvia fruticosa, Salvia miltiorrhiza (S4UX02), Salvia miltiorrhiza, Salvia rosmarinus
Manually annotated by BRENDA team
Bozic, D.; Papaefthimiou, D.; Brueckner, K.; de Vos, R.C.; Tsoleridis, C.A.; Katsarou, D.; Papanikolaou, A.; Pateraki, I.; Chatzopoulou, F.M.; Dimitriadou, E.; Kostas, S.; Manzano, D.; Scheler, U.; Ferrer, A.; Tissier, A.; Makris, A.M.; Kampranis, S.C.; Kanellis, A.K.
Towards elucidating carnosic acid biosynthesis in Lamiaceae Functional characterization of the three first steps of the pathway in Salvia fruticosa and Rosmarinus officinalis
PLoS ONE
10
e0124106
2015
Salvia fruticosa (A0A0C5QRZ2), Salvia rosmarinus (A0A0C5Q4Y6), Salvia rosmarinus (A0A0C5QEW3)
Manually annotated by BRENDA team