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IUBMB Comments A cytochrome P -450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of β-amyrin such as erythrodiol or oleanolic acid.
Synonyms
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C-16alpha hydroxylase
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CYP87D16
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
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beta-amyrin,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (16alpha-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of beta-amyrin such as erythrodiol or oleanolic acid.
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
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Substrates: no activity with lupeol
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
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Substrates: -
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
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Substrates: -
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
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UniProt
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Highest Expressing Human Cell Lines
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metabolism
the enzyme is involved in maesasaponin biosynthesis
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C87D1_MAELA
475
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53412
Swiss-Prot
Secretory Pathway (Reliability: 4 )
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expressed in Saccharomyces cerevisiae strain TM21
expressed in Saccharomyces cerevisiae strain TM48
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Moses, T.; Pollier, J.; Faizal, A.; Apers, S.; Pieters, L.; Thevelein, J.M.; Geelen, D.; Goossens, A.
Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata
Mol. Plant
8
122-135
2015
Maesa lanceolata (A0A0B4KZX8), Maesa lanceolata
brenda
Moses, T.; Pollier, J.; Almagro, L.; Buyst, D.; Van Montagu, M.; Pedreo, M.; Martins, J.; Thevelein, J.; Goossens, A.
Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16alpha hydroxylase from Bupleurum falcatum
Proc. Natl. Acad. Sci. USA
111
1634-1639
2014
Bupleurum falcatum
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