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3alpha-hydroxy-3,5-dihydromonacolin L acid
monacolin L acid + H2O
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
3alpha-hydroxy-3,5-dihydromonacolin L acid
monacolin L acid + H2O
Substrates: spontaneous
Products: (1b), spontaneous
?
3alpha-hydroxy-3,5-dihydromonacolin L acid
monacolin L acid + H2O
-
Substrates: spontaneous
Products: (1b), spontaneous
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin
Products: -
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase
Products: -
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: -
Products: product is unstable und under mildly acidic conditions and elevated temperature, it converts to monacolin L
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate
Products: -
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: reaction of cell free extract in presence of air
Products: -
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase
Products: -
?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
Substrates: monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
Products: -
?
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dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2
3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin
Products: -
?
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LOVA_ASPTN
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
528
0
60579
Swiss-Prot
-
MOKC_MONPI
524
0
60541
Swiss-Prot
Secretory Pathway (Reliability: 4)
LOVA_ASPTE
528
0
60593
Swiss-Prot
-
A0A0F0IBR4_ASPPU
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
523
0
59328
TrEMBL
-
A0A0F0ICV0_ASPPU
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
512
0
58176
TrEMBL
-
A0A0F0IKK3_ASPPU
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
507
0
57195
TrEMBL
other Location (Reliability: 1)
A0A0L1IP77_ASPN3
Aspergillus nomiae NRRL (strain ATCC 15546 / NRRL 13137 / CBS 260.88 / M93)
525
0
59563
TrEMBL
-
A0A0L1JHC4_ASPN3
Aspergillus nomiae NRRL (strain ATCC 15546 / NRRL 13137 / CBS 260.88 / M93)
508
0
57326
TrEMBL
-
A0A124BXE7_ASPNG
516
0
58582
TrEMBL
-
A0A1L9N015_ASPTC
Aspergillus tubingensis (strain CBS 134.48)
516
0
58569
TrEMBL
-
A0A1L9V0Y7_ASPBC
Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)
516
0
58366
TrEMBL
-
A0A1R3RXB0_ASPC5
Aspergillus carbonarius (strain ITEM 5010)
516
0
58360
TrEMBL
-
A0A1S9DKS4_ASPOZ
499
0
56896
TrEMBL
-
A0A1S9DF86_ASPOZ
507
0
57123
TrEMBL
-
A0A1S9DPB7_ASPOZ
520
0
58843
TrEMBL
other Location (Reliability: 2)
A0A2G7FX09_9EURO
523
0
59367
TrEMBL
other Location (Reliability: 1)
A0A2G7FZE6_9EURO
499
0
56647
TrEMBL
Mitochondrion (Reliability: 4)
A0A2G7G6Q8_9EURO
507
0
57261
TrEMBL
-
A0A2I1CZT3_ASPC2
Aspergillus campestris (strain IBT 28561)
522
0
58953
TrEMBL
-
A0A2I2F8A2_ASPCN
508
0
57316
TrEMBL
other Location (Reliability: 2)
A0A2I2FKL3_ASPCN
522
0
58914
TrEMBL
other Location (Reliability: 3)
A0A2J5HX42_9EURO
523
0
59148
TrEMBL
-
A0A2J5I9H5_9EURO
508
0
57013
TrEMBL
-
A0A2J5I5F2_9EURO
499
0
56459
TrEMBL
-
A0A317US14_ASPEC
Aspergillus eucalypticola (strain CBS 122712 / IBT 29274)
516
0
58511
TrEMBL
-
A0A317X0S2_9EURO
516
0
58548
TrEMBL
other Location (Reliability: 2)
A0A318Z283_ASPNB
Aspergillus neoniger (strain CBS 115656)
516
0
58546
TrEMBL
-
A0A319BIN9_ASPVC
Aspergillus vadensis (strain CBS 113365 / IMI 142717 / IBT 24658)
516
0
58504
TrEMBL
-
A0A319EMB5_ASPSB
Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)
516
0
58448
TrEMBL
-
A0A370BQB5_ASPNG
559
0
63431
TrEMBL
Mitochondrion (Reliability: 2)
A0A395H0P3_9EURO
516
0
58394
TrEMBL
-
A0A3F3QBV3_9EURO
516
0
58484
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3F3RSS0_ASPNG
516
0
58496
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5M3Z4C4_ASPTE
524
0
59164
TrEMBL
-
A0A5M9MH98_9EURO
569
0
64548
TrEMBL
-
A0A5N5WP42_9EURO
501
0
56612
TrEMBL
other Location (Reliability: 4)
A0A5N5X5X5_9EURO
541
0
61190
TrEMBL
-
A0A5N5WT53_9EURO
512
0
58039
TrEMBL
-
A0A5N6DQ03_ASPPA
507
0
57235
TrEMBL
-
A0A5N6DNK1_ASPPA
523
0
59328
TrEMBL
-
A0A5N6E490_ASPPA
499
0
56652
TrEMBL
-
A0A5N6EF53_9EURO
544
0
61652
TrEMBL
-
A0A5N6ES32_9EURO
498
0
56526
TrEMBL
-
A0A5N6FY35_PETAA
522
0
59311
TrEMBL
other Location (Reliability: 2)
A0A5N6F907_9EURO
507
0
57460
TrEMBL
-
A0A5N6GWN9_ASPFL
499
0
56701
TrEMBL
-
A0A5N6HMB0_9EURO
523
0
59482
TrEMBL
-
A0A5N6HDT6_ASPFL
507
0
57193
TrEMBL
Mitochondrion (Reliability: 5)
A0A5N6HBX3_ASPFL
544
0
61604
TrEMBL
-
A0A5N6JFC6_9EURO
507
0
57014
TrEMBL
-
A0A5N6JMZ0_9EURO
499
0
56966
TrEMBL
-
A0A5N6SQ19_ASPPS
523
0
59556
TrEMBL
-
A0A5N6TD86_9EURO
524
0
59675
TrEMBL
-
A0A5N6UJE8_ASPTM
523
0
59580
TrEMBL
-
A0A5N6VBZ1_ASPTM
507
0
57852
TrEMBL
-
A0A5N6V7E3_ASPTM
503
0
56814
TrEMBL
other Location (Reliability: 2)
A0A5N6VUK8_9EURO
499
0
56848
TrEMBL
Mitochondrion (Reliability: 4)
A0A5N6WIX5_9EURO
544
0
61733
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5N6X453_9EURO
499
0
56767
TrEMBL
-
A0A5N6X5P9_9EURO
523
0
59207
TrEMBL
-
A0A5N6XH21_9EURO
507
0
57641
TrEMBL
-
A0A5N6YK56_9EURO
499
0
56732
TrEMBL
-
A0A5N6YJ85_9EURO
507
0
57313
TrEMBL
-
A0A5N6Z7E9_9EURO
524
0
59388
TrEMBL
-
A0A5N7A870_9EURO
499
0
56763
TrEMBL
-
A0A5N7AHU0_9EURO
523
0
59520
TrEMBL
-
A0A5N7ALS0_9EURO
507
0
57662
TrEMBL
-
A0A5N7B0F8_9EURO
546
0
62398
TrEMBL
-
A0A5N7ATB9_9EURO
522
0
59384
TrEMBL
other Location (Reliability: 5)
A0A5N7B849_9EURO
506
0
57474
TrEMBL
-
A0A5N7CDE4_PETAA
483
0
54860
TrEMBL
-
A0A5N7DG70_9EURO
507
0
57551
TrEMBL
-
A0A6J3X1M5_9EURO
508
0
57115
TrEMBL
-
A0A7D5BQ45_9EURO
508
0
57119
TrEMBL
-
A0A7R7WJW5_ASPKA
516
0
58557
TrEMBL
-
A0A7U2MGF2_ASPFN
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)
499
0
56836
TrEMBL
-
A0A7U2QRS8_ASPFN
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)
523
0
59254
TrEMBL
-
A0A8G1R4F7_9EURO
516
0
58524
TrEMBL
-
A0A8H3SVG4_ASPTU
516
0
58582
TrEMBL
-
A0A9W5YPE6_9EURO
516
0
58352
TrEMBL
-
A0A9W6A840_ASPNG
510
0
57816
TrEMBL
-
A0AAD4CMZ1_ASPNN
750
0
84363
TrEMBL
-
A0AAD4GS40_ASPNN
525
0
59404
TrEMBL
Secretory Pathway (Reliability: 4)
A0AAJ8BQS2_ASPNG
577
0
65576
TrEMBL
other Location (Reliability: 3)
A0AB74BSV0_ASPFL
496
0
56358
TrEMBL
other Location (Reliability: 3)
A0AB74C4S1_ASPFL
523
0
59226
TrEMBL
-
A0AB74CD98_ASPFL
507
0
57296
TrEMBL
-
A2QVM8_ASPNC
Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
577
0
65576
TrEMBL
-
D4QC68_ASPOZ
499
0
56870
TrEMBL
-
D4QC43_ASPOZ
507
0
57194
TrEMBL
-
D4QC99_ASPOZ
523
0
59226
TrEMBL
-
G3YC66_ASPNA
Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
516
0
58496
TrEMBL
Secretory Pathway (Reliability: 1)
I8A9P1_ASPO3
Aspergillus oryzae (strain 3.042)
499
0
56870
TrEMBL
-
I7ZLP9_ASPO3
Aspergillus oryzae (strain 3.042)
523
0
59198
TrEMBL
Secretory Pathway (Reliability: 2)
I8TMV7_ASPO3
Aspergillus oryzae (strain 3.042)
507
0
57193
TrEMBL
-
Q0CKE0_ASPTN
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
524
0
59025
TrEMBL
-
Q0CV32_ASPTN
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
499
0
56259
TrEMBL
-
Q2TWF1_ASPOR
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
507
0
57194
TrEMBL
-
Q2UIZ6_ASPOR
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
499
0
56870
TrEMBL
-
Q2UM74_ASPOR
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
523
0
59226
TrEMBL
other Location (Reliability: 2)
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Barriuso, J.; Nguyen, D.T.; Li, J.W.; Roberts, J.N.; MacNevin, G.; Chaytor, J.L.; Marcus, S.L.; Vederas, J.C.; Ro, D.K.
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA
J. Am. Chem. Soc.
133
8078-8081
2011
Aspergillus terreus (Q9Y7C8)
brenda
Nakamura, T.; Komagata, D.; Murakawa, S.; Sakai, K.; Endo, A.
Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L
J. Antibiot.
43
1597-1600
1990
Monascus ruber
brenda
Treiber, L.; Reamer, R.; Rooney, C.; Ramjit, H.
Origin of monacolin L from Aspergillus terreus cultures
J. Antibiot.
42
30-36
1989
Aspergillus terreus
brenda
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