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IUBMB Comments A cytochrome P -450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
Synonyms ftmC , FtmC protein,
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EC 1.14.13.176
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ftmC
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FtmC protein
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
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MetaCyc
fumitremorgin C biosynthesis
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tryprostatin B,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
Substrates: -
?
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Gene Links
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malfunction
disruption of the ftmC gene leads to substantial accumulation of tryprostatin B and its cyclization product demethoxyfumitremorgin C
malfunction
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disruption of the ftmC gene leads to substantial accumulation of tryprostatin B and its cyclization product demethoxyfumitremorgin C
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FTMC_ASPFM
559
3
64183
Swiss-Prot
other Location (Reliability: 4 )
FTMC_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
559
3
64183
Swiss-Prot
other Location (Reliability: 4 )
FTMC_NEOFI
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
548
3
63189
Swiss-Prot
Secretory Pathway (Reliability: 3 )
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expressed in Saccharomyces cerevisiae strain YPH500
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Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus
ChemBioChem
10
920-928
2009
Aspergillus fumigatus (B9WZX1), Aspergillus fumigatus BM939 (B9WZX1)
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