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2,3,5,6-Tetrafluoro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
2,3,5,6-Tetrafluoro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
2,4-Dihydroxybenzoate + NADH + O2
1,2,4-Trihydroxybenzene + NAD+ + CO2
2,4-dihydroxybenzoate + NADPH + O2
1,2,4-trihydroxybenzene + NADP+ + CO2
-
-
-
-
2,5-Difluoro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
2,5-Difluoro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
2,6-Difluoro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
2,6-Difluoro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
2-chloro-4-hydroxybenzoate + NADH + O2
?
2-Chloro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
2-fluoro-4-hydroxybenzoate + NADH + O2
2-fluoro-1,4-dihydroxybenzene + NAD+ + CO2
2-fluoro-4-hydroxybenzoate + NADPH + O2
2-fluoro-1,4-dihydroxybenzene + NADP+ + CO2
-
-
-
-
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
3,4-Dihydroxybenzoate + NADH + O2
1,2,4-Trihydroxybenzene + NAD+ + CO2
-
-
-
-
3,4-Dihydroxybenzoate + NADPH + O2
1,2,4-Trihydroxybenzene + NADP+ + CO2
-
-
-
-
3,5-Difluoro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
3,5-Difluoro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
3-Amino-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
3-Amino-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
3-Chloro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
3-Chloro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
3-Fluoro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
3-Fluoro-4-hydroxybenzoate + NADPH + O2
?
-
-
-
-
-
4-Hydroxy-3-methoxybenzoate + NADH + O2
?
-
-
-
-
-
4-Hydroxy-3-methoxybenzoate + NADPH + O2
?
-
-
-
-
-
4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
4-Hydroxy-3-nitrobenzoate + NADH + O2
?
-
-
-
-
-
4-Hydroxy-3-nitrobenzoate + NADPH + O2
?
-
-
-
-
-
4-hydroxybenzoate + NAD(P)H + H+ + O2
hydroquinone + NAD(P)+ + H2O + CO2
4-Hydroxybenzoate + NAD(P)H + O2
?
4-hydroxybenzoate + NADH + 2 H+ + O2
hydroquinone + NAD+ + H2O + CO2
4-Hydroxybenzoate + NADH + O2
1,4-Dihydroxybenzene + NAD+ + CO2
4-hydroxybenzoate + NADH + O2
hydroquinone + NAD+ + CO2
4-Hydroxybenzoate + NADPH + O2
1,4-Dihydroxybenzene + NADP+ + CO2
4-hydroxybenzoate + NADPH + O2
hydroquinone + NADP+ + CO2
protocatechuate + NAD(P)H + H+ + O2
?
tetrafluoro-4-hydroxybenzoate + NAD(P)H + O2
2,3,5,6-tetrafluorohydroquinone + NAD(P)+ + CO2
-
-
-
-
?
additional information
?
-
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2

benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
2,4-Dihydroxybenzoate + NADH + O2

1,2,4-Trihydroxybenzene + NAD+ + CO2
-
-
-
-
2,4-Dihydroxybenzoate + NADH + O2
1,2,4-Trihydroxybenzene + NAD+ + CO2
-
-
-
-
2-chloro-4-hydroxybenzoate + NADH + O2

?
-
-
-
-
-
2-chloro-4-hydroxybenzoate + NADH + O2
?
-
-
-
-
-
2-fluoro-4-hydroxybenzoate + NADH + O2

2-fluoro-1,4-dihydroxybenzene + NAD+ + CO2
-
-
-
-
2-fluoro-4-hydroxybenzoate + NADH + O2
2-fluoro-1,4-dihydroxybenzene + NAD+ + CO2
-
-
-
-
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2

benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-hydroxy-3-nitrobenzoate + NAD(P)H + O2

2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
-
-
-
?
4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
-
-
-
?
4-hydroxybenzoate + NAD(P)H + H+ + O2

hydroquinone + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-hydroxybenzoate + NAD(P)H + H+ + O2
hydroquinone + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-Hydroxybenzoate + NAD(P)H + O2

?
-
initial reaction of the catabolism of 4-hydroxybenzoate
-
-
-
4-Hydroxybenzoate + NAD(P)H + O2
?
-
the enzyme is induced when the yeast is grown on either 4-hydroxybenzoate, 2,3-dihydroxybenzoate, or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
4-Hydroxybenzoate + NAD(P)H + O2
?
-
initial reaction of the catabolism of 4-hydroxybenzoate
-
-
-
4-hydroxybenzoate + NADH + 2 H+ + O2

hydroquinone + NAD+ + H2O + CO2
-
-
-
-
?
4-hydroxybenzoate + NADH + 2 H+ + O2
hydroquinone + NAD+ + H2O + CO2
-
-
-
-
?
4-Hydroxybenzoate + NADH + O2

1,4-Dihydroxybenzene + NAD+ + CO2
-
-
-
-
4-Hydroxybenzoate + NADH + O2
1,4-Dihydroxybenzene + NAD+ + CO2
-
NADH is the preferred electron donor
-
-
4-Hydroxybenzoate + NADH + O2
1,4-Dihydroxybenzene + NAD+ + CO2
-
-
-
-
4-Hydroxybenzoate + NADH + O2
1,4-Dihydroxybenzene + NAD+ + CO2
-
NADH is the preferred electron donor
-
-
4-hydroxybenzoate + NADH + O2

hydroquinone + NAD+ + CO2
-
the enzyme prefers NADH over NADPH as electron donor
-
-
?
4-hydroxybenzoate + NADH + O2
hydroquinone + NAD+ + CO2
-
the enzyme prefers NADH over NADPH as electron donor
-
-
?
4-Hydroxybenzoate + NADPH + O2

1,4-Dihydroxybenzene + NADP+ + CO2
-
-
-
-
4-Hydroxybenzoate + NADPH + O2
1,4-Dihydroxybenzene + NADP+ + CO2
-
NADH is the preferred electron donor
-
-
4-Hydroxybenzoate + NADPH + O2
1,4-Dihydroxybenzene + NADP+ + CO2
-
-
-
-
4-Hydroxybenzoate + NADPH + O2
1,4-Dihydroxybenzene + NADP+ + CO2
-
NADH is the preferred electron donor
-
-
4-hydroxybenzoate + NADPH + O2

hydroquinone + NADP+ + CO2
-
the enzyme prefers NADH over NADPH as electron donor
-
-
?
4-hydroxybenzoate + NADPH + O2
hydroquinone + NADP+ + CO2
-
the enzyme prefers NADH over NADPH as electron donor
-
-
?
protocatechuate + NAD(P)H + H+ + O2

?
-
-
-
-
?
protocatechuate + NAD(P)H + H+ + O2
?
-
-
-
-
?
additional information

?
-
-
the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
additional information
?
-
-
the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring
-
-
-
additional information
?
-
-
the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
additional information
?
-
-
the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
4-hydroxybenzoate + NAD(P)H + H+ + O2
hydroquinone + NAD(P)+ + H2O + CO2
4-Hydroxybenzoate + NAD(P)H + O2
?
protocatechuate + NAD(P)H + H+ + O2
?
additional information
?
-
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2

benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
2,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2

benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
3,4-dihydroxybenzoate + NAD(P)H + H+ + O2
benzene-1,2,4-triol + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-hydroxybenzoate + NAD(P)H + H+ + O2

hydroquinone + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-hydroxybenzoate + NAD(P)H + H+ + O2
hydroquinone + NAD(P)+ + H2O + CO2
-
-
-
-
?
4-Hydroxybenzoate + NAD(P)H + O2

?
-
initial reaction of the catabolism of 4-hydroxybenzoate
-
-
-
4-Hydroxybenzoate + NAD(P)H + O2
?
-
the enzyme is induced when the yeast is grown on either 4-hydroxybenzoate, 2,3-dihydroxybenzoate, or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
4-Hydroxybenzoate + NAD(P)H + O2
?
-
initial reaction of the catabolism of 4-hydroxybenzoate
-
-
-
protocatechuate + NAD(P)H + H+ + O2

?
-
-
-
-
?
protocatechuate + NAD(P)H + H+ + O2
?
-
-
-
-
?
additional information

?
-
-
the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
additional information
?
-
-
the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
van Berkel, W.J.H.; Eppink, M.H.M.; Middelhoven, W.J.; Vervoort, J.; Rietjens, I.M.C.M.
Catabolism of 4-hydroxybenzoate in Candida parapsilosis proceeds through initial oxidative decarboxylation by a FAD-dependent 4-hydroxybenzoate 1-hydroxylase
FEMS Microbiol. Lett.
121
207-216
1994
Candida parapsilosis, Candida parapsilosis CBS604
brenda
Eppink, M.H.M.; Boeren, S.A.; Vervoort, J.; van Berkel, W.J.H.
Purification and properties of 4-hydroxybenzoate 1-hydroxylase (decarboxylating), a novel flavin adenine dinucleotide-dependent monooxygenase from Candida parapsilosis CBS604
J. Bacteriol.
179
6680-6687
1997
Candida parapsilosis, Candida parapsilosis CBS604
brenda
Moonen, M.J.H.; Fraaije, M.W.; Rietjens, I.M.C.M.; Laane, C.; Van Berkel, W.J.H.
Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds
Adv. Synth. Catal.
344
1023-1035
2002
Candida parapsilosis, Candida parapsilosis CBS604
-
brenda
Holesova, Z.; Jakubkova, M.; Zavadiakova, I.; Zeman, I.; Tomaska, L.; Nosek, J.
Gentisate and 3-oxoadipate pathways in the yeast Candida parapsilosis: identification and functional analysis of the genes coding for 3-hydroxybenzoate 6-hydroxylase and 4-hydroxybenzoate 1-hydroxylase
Microbiology
157
2152-2163
2011
Candida parapsilosis
brenda
Shen, X.; Wang, J.; Wang, J.; Chen, Z.; Yuan, Q.; Yan, Y.
High-level de novo biosynthesis of arbutin in engineered Escherichia coli
Metab. Eng.
42
52-58
2017
Candida parapsilosis, Candida parapsilosis CBS604
brenda