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Information on EC 1.14.13.33 - 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]

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IUBMB Comments
A flavoprotein (FAD). The enzyme from Corynebacterium cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses NADH and NADPH at approximately equal rates (cf. EC 1.14.13.2 4-hydroxybenzoate 3-monooxygenase). It is less specific for NADPH than EC 1.14.13.2.
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The enzyme appears in viruses and cellular organisms
Synonyms
4-HBA 3-hydroxylase, 4-HBA 3-monooxygenase, 4-hydroxybenzoate 3-hydroxylase, 4-hydroxybenzoate 3-monooxygenase (NAD(P)H), 4-hydroxybenzoate 3-monooxygenase (NAD(P)H2), 4-hydroxybenzoate-3-hydroxylase, 4HB 3-hydroxylase, oxygenase, 4-hydroxybenzoate 3-mono- (reduced nicotinamide adenine dinucleotide (phosphate)), PobA, Xcc0356, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O
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