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Information on EC 1.14.13.248 - L-aspartate N-monooxygenase (nitrosuccinate-forming)

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EC Tree
IUBMB Comments
The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites. Requires an FAD cofactor.
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The expected taxonomic range for this enzyme is: Streptomyces
Reaction Schemes
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Synonyms
bn159_4422, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-2-nitrosobutanedioate + NADPH + H+ + O2 = (2S)-2-nitrobutanedioate + NADP+ + H2O
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1d
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L-aspartate + 3 NADPH + 3 H+ + 3 O2 = (2S)-2-nitrobutanedioate + 3 NADP+ + 4 H2O
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L-aspartate + NADPH + H+ + O2 = N-hydroxy-L-aspartate + NADP+ + H2O
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1a
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N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O
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1c, spontaneous
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N-hydroxy-L-aspartate + NADPH + H+ + O2 = N,N-dihydroxy-L-aspartate + NADP+ + H2O
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1b
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