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EC Tree
IUBMB Comments The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit is a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues.
Word Map
1.14.13.239
surfactant
bromide
tension
micelle
adsorbed
alkyltrimethylammonium
air-water
interfacial
alkane
reorientation
baumannii
n-alkyl
langmuir
rieske-type
fluorocarbon
flocculation
anisotropic
co-adsorption
rieske
The enzyme appears in viruses and cellular organisms
Synonyms
carnitine TMA lyase,
cntAB ,
yeaWX ,
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carnitine TMA lyase
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cntAB
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yeaWX
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L-carnitine + NAD(P)H + H+ + O2 = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD(P)+ + H2O
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L-carnitine,NAD(P)H:oxygen oxidoreductase (trimethylamine-forming)
The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit is a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues.
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D-carnitine + NADH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
D-carnitine + NADPH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
D-carnitine + NADH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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D-carnitine + NADH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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D-carnitine + NADH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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D-carnitine + NADPH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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D-carnitine + NADPH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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D-carnitine + NADPH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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the enzyme shows higher activity with D-carnitine compared to L-carnitine
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
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NADH
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NADPH
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alpha subunit and beta subunit
SwissProt
brenda
alpha subunit and beta subunit
SwissProt
brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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His-tag affinity column chromatography
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expressed in Escherichia coli BL21pLysS cells
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expressed in Escherichia coli BLR(DE3) pLysS cells
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Ditullio, D.; Anderson, D.; Chen, C.S.; Sih, C.J.
L-carnitine via enzyme-catalyzed oxidative kinetic resolution
Bioorg. Med. Chem.
2
415-420
1994
Acinetobacter calcoaceticus, Acinetobacter calcoaceticus ATCC 39648, Acinetobacter calcoaceticus ATCC 39647
brenda
Koeth, R.; Levison, B.; Culley, M.; Buffa, J.; Wang, Z.; Gregory, J.; Org, E.; Wu, Y.; Li, L.; Smith, J.; Tang, W.; Didonato, J.; Lusis, A.; Hazen, S.
gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO
Cell Metab.
20
799-812
2014
Escherichia coli, Escherichia coli DH10B
brenda
Zhu, Y.; Jameson, E.; Crosatti, M.; Schaefer, H.; Rajakumar, K.; Bugg, T.D.; Chen, Y.
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
Proc. Natl. Acad. Sci. USA
111
4268-4273
2014
Acinetobacter baumannii (D0C9N6 AND D0C9N8), Acinetobacter baumannii, Acinetobacter baumannii ATCC19606 (D0C9N6 AND D0C9N8)
brenda
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Enzyme Nomenclature
1.14.13.239 carnitine monooxygenase
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