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Information on EC 1.14.13.231 - tetracycline 11a-monooxygenase

for references in articles please use BRENDA:EC1.14.13.231
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IUBMB Comments
A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.
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The enzyme appears in viruses and cellular organisms
Synonyms
tetx2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
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tetracycline + NADPH + H+ + O2 = 11a-hydroxytetracycline + NADP+ + H2O
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