The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on propan-2-ol, converting it to propane-1,2-diol. Depending on the substrate, the enzyme also catalyses EC 1.14.19.48, tert-amyl alcohol desaturase.
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SYSTEMATIC NAME
IUBMB Comments
tert-butyl alcohol,NADPH:oxygen oxidoreductase
The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on propan-2-ol, converting it to propane-1,2-diol. Depending on the substrate, the enzyme also catalyses EC 1.14.19.48, tert-amyl alcohol desaturase.
degradation of tert-butyl alcohol leads to formation of isobutene. Both tert-alkyl alcohol degradation and alkene production are strictly oxygen dependent, the relative contribution of the dehydration reaction to total alcohol conversion increases with decreasing oxygen concentrations
degradation of tert-butyl alcohol leads to formation of isobutene. Both tert-alkyl alcohol degradation and alkene production are strictly oxygen dependent, the relative contribution of the dehydration reaction to total alcohol conversion increases with decreasing oxygen concentrations
degradation of tert-butyl alcohol leads to formation of isobutene. Both tert-alkyl alcohol degradation and alkene production are strictly oxygen dependent, the relative contribution of the dehydration reaction to total alcohol conversion increases with decreasing oxygen concentrations
MdpJ knockout mutants are not able to grow on the tertiary alcohols tert-butanol and tert-amyl alcohol, whereas 2-methylpropan-1,2-diol, the putative product of tert-butanol hydroxylation by MdpJ catalysis can still be used as the sole source of energy and carbon. The postulated 2-methylpropan-1,2-diol intermediate 2-hydroxyisobutanoate is metabolized by wild-type and mutant strains at the same rates
degradation of tert-butyl alcohol leads to formation of isobutene. Both tert-alkyl alcohol degradation and alkene production are strictly oxygen dependent, the relative contribution of the dehydration reaction to total alcohol conversion increases with decreasing oxygen concentrations; MdpJ knockout mutants are not able to grow on the tertiary alcohols tert-butanol and tert-amyl alcohol, whereas 2-methylpropan-1,2-diol, the putative product of tert-butanol hydroxylation by MdpJ catalysis can still be used as the sole source of energy and carbon. The postulated 2-methylpropan-1,2-diol intermediate 2-hydroxyisobutanoate is metabolized by wild-type and mutant strains at the same rates
Schaefer, F.; Breuer, U.; Benndorf, D.; von Bergen, M.; Harms, H.; Mueller, R.
Growth of Aquincola tertiaricarbonis L108 on tert-butyl alcohol leads to the induction of a phthalate dioxygenase-related protein and its associated oxidoreductase subunit
Schuster, J.; Schaefer, F.; Huebler, N.; Brandt, A.; Rosell, M.; Haertig, C.; Harms, H.; Mueller, R.H.; Rohwerder, T.
Bacterial degradation of tert-amyl alcohol proceeds via hemiterpene 2-methyl-3-buten-2-ol by employing the tertiary alcohol desaturase function of the Rieske nonheme mononuclear iron oxygenase MdpJ
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1.14.13.229 tert-butyl alcohol monooxygenase
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