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Information on EC 1.14.13.227 - propane 2-monooxygenase and Organism(s) Rhodococcus jostii and UniProt Accession Q0SJK9

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IUBMB Comments
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
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Rhodococcus jostii
UNIPROT: Q0SJK9
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The taxonomic range for the selected organisms is: Rhodococcus jostii
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
prmabcd, propane 2-monooxygenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
prmABCD
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
propane,NADH:oxygen oxidoreductase (2-hydroxylating)
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
large subunit PrmA
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
deletion mutagenesis of prmA, the gene encoding the large hydroxylase component of propane monooxygenase, abolishes both growth on propane and removal of N-nitrosodimethylamine from growth medium
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
degradation
Rhodococcus sp. strain RHA1 can constitutively degrade N-nitrosodimethylamine. Activity toward this water contaminant is enhanced by approximately 500fold after growth on propane. Growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sharp, J.; Sales, C.; LeBlanc, J.; Liu, J.; Wood, T.; Eltis, L.; Mohn, W.; Alvarez-Cohen, L.
An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1
Appl. Environ. Microbiol.
73
6930-6938
2007
Rhodococcus jostii (Q0SJK9)
Manually annotated by BRENDA team