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EC Tree
IUBMB Comments The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
The enzyme appears in viruses and cellular organisms
Synonyms
Prm1ABCD, PrmA,
prmABCD ,
RHA1_ro00441 ,
more
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Prm1ABCD
Q08KD8 ; Q08KD7 and Q08KD6; Q08KD5, Q08KE2 ; Q08KE1 and Q08KE0; Q08KD9-
prmABCD
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prmABCD
Q768T5 ; Q768T4 and Q768T3; Q768T2
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propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O
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propane,NADH:oxygen oxidoreductase (2-hydroxylating)
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
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propane + NADPH + H+ + O2
propan-2-ol + NADP+ + H2O
Q08KD8 ; Q08KD7 and Q08KD6; Q08KD5, Q08KE2 ; Q08KE1 and Q08KE0; Q08KD9-
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Iron
Q768T5 ; Q768T4 and Q768T3; Q768T2
enzyme is a dinuclear-iron-containing multicomponent monooxygenase
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Q768T5 i.e. subunit PrmA, Q768T4 i.e. subunit PrmB, Q768T3 i.e. subunit PrmC, Q768T2 i.e. subunit PrmD
Q768T5 ; Q768T4 and Q768T3; Q768T2
UniProt
brenda
large subunit PrmA
UniProt
brenda
Q08KD8 i.e. subunit Prm1A, Q08KD7 i.e. subunit Prm1B, Q08KD6 i.e. subunit Prm1C, Q08KD5 i.e. subunit Prm1D, respectively
Q08KD8 ; Q08KD7 and Q08KD6; Q08KD5
UniProt
brenda
Q08KE2 i.e. subunit Prm1A, Q08KE1 i.e. subunit Prm1B, Q08KD0 i.e. subunit Prm1C, Q08KE9 i.e. subunit Prm1D, respectively
Q08KE2 ; Q08KE1 and Q08KE0; Q08KD9
UniProt
brenda
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physiological function
deletion mutagenesis of prmA, the gene encoding the large hydroxylase component of propane monooxygenase, abolishes both growth on propane and removal of N-nitrosodimethylamine from growth medium
physiological function
Q768T5 ; Q768T4 and Q768T3; Q768T2
disruption of the gene encoding subunit PrmB leads to loss of the ability to grow on propane
physiological function
Q08KD8 ; Q08KD7 and Q08KD6; Q08KD5, Q08KE2 ; Q08KE1 and Q08KE0; Q08KD9propane is oxidized to 1-propanol and 2-propanol through both terminal and subterminal oxidations in Pseudonocardia sp. TY-7
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expression of prm gene clusters is induced by gaseous n-alkanes (C2-C4) except methane
Q08KD8 ; Q08KD7 and Q08KD6; Q08KD5, Q08KE2 ; Q08KE1 and Q08KE0; Q08KD9
growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes
polycistronic transcription of the prm genes is induced during its growth on propane
Q768T5 ; Q768T4 and Q768T3; Q768T2
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degradation
Rhodococcus sp. strain RHA1 can constitutively degrade N-nitrosodimethylamine. Activity toward this water contaminant is enhanced by approximately 500fold after growth on propane. Growth on propane elicits the upregulation of gene clusters associated with the oxidation of propane and the oxidation of substituted benzenes
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Sharp, J.; Sales, C.; LeBlanc, J.; Liu, J.; Wood, T.; Eltis, L.; Mohn, W.; Alvarez-Cohen, L.
An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1
Appl. Environ. Microbiol.
73
6930-6938
2007
Rhodococcus jostii (Q0SJK9)
brenda
Kotani, T.; Yamamoto, T.; Yurimoto, H.; Sakai, Y.; Kato, N.
Propane monooxygenase and NAD+-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5
J. Bacteriol.
185
7120-7128
2003
Gordonia sp. (Q768T5 and Q768T4 and Q768T3 and Q768T2), Gordonia sp.
brenda
Kotani, T.; Kawashima, Y.; Yurimoto, H.; Kato, N.; Sakai, Y.
Gene structure and regulation of alkane monooxygenases in propane-utilizing Mycobacterium sp. TY-6 and Pseudonocardia sp. TY-7
J. Biosci. Bioeng.
102
184-192
2006
Pseudonocardia sp. TY-7 (Q08KD8 and Q08KD7 and Q08KD6 and Q08KD5), Pseudonocardia sp. TY-7 (Q08KE2 and Q08KE1 and Q08KE0 and Q08KD9)
brenda
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