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BRENDA support

Information on EC 1.14.13.225 - F-actin monooxygenase

for references in articles please use BRENDA:EC1.14.13.225

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IUBMB Comments

The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization . Free methionine is not a substrate . The reaction is stereospecific and generates the (R)-sulfoxide . In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5].

The enzyme appears in viruses and cellular organisms
Reaction Schemes
[F-actin]-L-methionine
+
+
+
=
[F-actin]-L-methionine-(R)-S-oxide
+
+

Synonyms
mical, mical2, mical1, mical-1, mical3, mical-2, mical2pv, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
show the reaction diagram
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Highest Expressing Human Cell Lines
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