show all | hide all No of entries

Information on EC 1.14.13.225 - F-actin monooxygenase

for references in articles please use BRENDA:EC1.14.13.225
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization . Free methionine is not a substrate . The reaction is stereospecific and generates the (R)-sulfoxide .
Specify your search results
Select one or more organisms in this record:
Word Map
  • 1.14.13.225
  • plexins
  • calponine
  • semaphorin-plexin
  • sema3a
  • semaphorin3a
  • plexa
The enzyme appears in viruses and cellular organisms
Reaction Schemes
[F-actin]-L-methionine
+
+
+
=
[F-actin]-L-methionine-(R)-S-oxide
+
+
Synonyms
mical, mical1, mical-1, mical2, mical-2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
Select items on the left to see more content.