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Information on EC 1.14.13.22 - cyclohexanone monooxygenase

for references in articles please use BRENDA:EC1.14.13.22

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IUBMB Comments

A flavoprotein (FAD). In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen . This enzyme is able to catalyse a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions , sulfoxidations , amine oxidations and epoxidations .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
cyclohexanone monooxygenase, cyclohexanone oxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cyclohexanone + NADPH + H+ + O2 = hexano-6-lactone + NADP+ + H2O
show the reaction diagram