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Information on EC 1.14.13.212 - 1,3,7-trimethyluric acid 5-monooxygenase

for references in articles please use BRENDA:EC1.14.13.212

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IUBMB Comments

The enzyme, characterized from the bacterium Pseudomonas sp. CBB1, is part of the bacterial C-8 oxidation-based caffeine degradation pathway. The product decomposes spontaneously to a racemic mixture of 3,6,8-trimethylallantoin. The enzyme shows no acitivity with urate. cf. EC 1.14.13.113, FAD-dependent urate hydroxylase.

The expected taxonomic range for this enzyme is: Pseudomonas sp.

Synonyms
nadh-dependent trimethyluric acid monooxygenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,3,7-trimethylurate + NADH + H+ + O2 = 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O
show the reaction diagram
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