Information on EC 1.14.13.209 - salicyloyl-CoA 5-hydroxylase

for references in articles please use BRENDA:EC1.14.13.209

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EC Tree 1 Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor 1.14.13.209 salicyloyl-CoA 5-hydroxylase

IUBMB Comments

The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase.

The enzyme appears in viruses and cellular organisms

1.14.13.209
urodynamic
labas
neurourol
alpha-tropanyl-1h-indole-3-carboxylic
tiotropium

Reaction Schemes

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Synonyms
salicylyl-coa 5-hydroxylase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

salicylyl-CoA 5-hydroxylase

sdgC

sdgC

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O

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PATHWAY SOURCE

PATHWAYS

MetaCyc

salicylate degradation IV

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SYSTEMATIC NAME

IUBMB Comments

salicyloyl-CoA,NADH:oxygen oxidoreductase (5-hydroxylating)

The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

2-hydroxybenzoyl-CoA + NADH + H+ + O2

gentisyl-CoA + NAD+ + H2O

Streptomyces sp.

Q7X281

733151

Substrates: -
Products: -

additional information

2 entries

additional information

Streptomyces sp.

Q7X281

733151

Substrates: direct conversion of salicylate to gentisate is not observed
Products: -

additional information

Streptomyces sp.

733151

Substrates: direct conversion of salicylate to gentisate is not observed
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-hydroxybenzoyl-CoA + NADH + H+ + O2

gentisyl-CoA + NAD+ + H2O

Streptomyces sp.

Q7X281

733151

Substrates: -
Products: -

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADH

Streptomyces sp.

Q7X281

required, neither NADPH nor FAD can replace NADH

733151

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Streptomyces sp.

733151

Q7X281

UniProt

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q7X281 pBLAST

SDGC_STRSQ

Streptomyces sp

517

56572

Swiss-Prot