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Information on EC 1.14.13.171 - neopentalenolactone D synthase for references in articles please use BRENDA:EC1.14.13.171Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Streptomyces
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neopentalenolactone D synthase
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = neopentalenolactone D + NADP+ + H2O
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neopentalenoketolactone and pentalenate biosynthesis
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1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D forming)
A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction.
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penE
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pntE
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ptlE
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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1-deoxy-11-oxopentalenate + NADPH + H+ + O2
neopentalenolactone D + NADP+ + H2O
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FAD
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64000
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x * 64000, SDS-PAGE
65826
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x * 65826, predicted from amino acid sequence
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x * 64000, SDS-PAGE; x * 65826, predicted from amino acid sequence
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ammonium sulfate precipitation, butyl-Sepharose column chromatography, gel filtration
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expressed in Escherichia coli BL21(DE3) cells
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PTLE_STRAW
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
594
65925
Swiss-Prot
A0A100JSX2_STRSC
617
68586
TrEMBL
A0A1F2Q6C1_RHOER
597
67033
TrEMBL
A0A2X3L7U9_9ACTN
613
69407
TrEMBL
A0A245ZSY2_9SPHN
606
67710
TrEMBL
A0A231HAB0_9NOCA
608
68443
TrEMBL
A0AD32_STRAM
611
68190
TrEMBL
A0A2S8BH55_9MYCO
612
68693
TrEMBL
A0A2X3KRJ1_9ACTN
608
68382
TrEMBL
A0A2S8BC64_9MYCO
252
28324
TrEMBL
A0A2S6TWI1_9PROT
621
70235
TrEMBL
A0A0J6VVH8_9MYCO
612
68149
TrEMBL
A0A2U3Q3X4_9BRAD
617
69661
TrEMBL
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Jiang, J.; Tetzlaff, C.N.; Takamatsu, S.; Iwatsuki, M.; Komatsu, M.; Ikeda, H.; Cane, D.E.
Genome mining in Streptomyces avermitilis: A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree
Biochemistry
48
6431-6440
2009
Streptomyces avermitilis
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Seo, M.J.; Zhu, D.; Endo, S.; Ikeda, H.; Cane, D.E.
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone
Biochemistry
50
1739-1754
2011
Streptomyces arenae, Streptomyces arenae TUE469, Streptomyces avermitilis, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319
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