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Information on EC 1.14.13.113 - FAD-dependent urate hydroxylase and Organism(s) Klebsiella oxytoca and UniProt Accession B5B0J6

for references in articles please use BRENDA:EC1.14.13.113
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IUBMB Comments
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.
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This record set is specific for:
Klebsiella oxytoca
UNIPROT: B5B0J6
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The taxonomic range for the selected organisms is: Klebsiella oxytoca
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
urate hydroxylase, hpxo enzyme, fad-dependent urate oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming)
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
show the reaction diagram
part of the purine catabolic pathway
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
show the reaction diagram
part of the purine catabolic pathway
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HPXO_KLEOX
384
0
42130
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pope, S.D.; Chen, L.L.; Stewart, V.
Purine utilization by Klebsiella oxytoca M5al: genes for ring-oxidizing and -opening enzymes
J. Bacteriol.
191
1006-1017
2008
Klebsiella oxytoca (B5B0J6), Klebsiella oxytoca M5al (B5B0J6)
Manually annotated by BRENDA team