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Information on EC 1.14.12.8 - 4-sulfobenzoate 3,4-dioxygenase

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IUBMB Comments
A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.
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Word Map
  • 1.14.12.8
  • 25-hydroxyvitamin
  • cyp24a1
  • 1,25-dihydroxyvitamin
  • rickets
  • d-dependent
  • 1alpha-hydroxylase
  • 1alpha,25-dihydroxyvitamin
  • hypocalcemia
  • 1alpha-hydroxylation
  • extra-renal
  • non-renal
  • d3-1alpha-hydroxylase
  • hypophosphatemia
The expected taxonomic range for this enzyme is: Comamonas testosteroni
Synonyms
4-sulfobenzoate 3,4-dioxygenase system, oxygenase, 4-sulfobenzoate di-, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + sulfite + NAD+
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