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Information on EC - nitroarene dioxygenase

for references in articles please use BRENDA:EC1.14.12.23
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IUBMB Comments
This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It can typically act on many different nitroaromatic compounds, including chlorinated species. Enzymes found in different strains may have different substrate preferences. Requires Fe2+.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
2ntdo, nitroarene dioxygenase, mntab, cnbaa, cnbab, cnbac, cnbad, nbzaa, nbzab, nbzac, more
nitrobenzene + NADH + O2 = catechol + nitrite + NAD+
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