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Information on EC 1.14.12.1 - anthranilate 1,2-dioxygenase (deaminating, decarboxylating) and Organism(s) Burkholderia cepacia and UniProt Accession Q84BZ3

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EC Tree
IUBMB Comments
Requires Fe2+.
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This record set is specific for:
Burkholderia cepacia
UNIPROT: Q84BZ3
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Word Map
The taxonomic range for the selected organisms is: Burkholderia cepacia
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
antdo, two-component anthranilate 1,2-dioxygenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
anthranilate hydroxylase
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anthranilic acid hydroxylase
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anthranilic hydroxylase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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Deamination
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redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Requires Fe2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-17-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
anthranilic acid + alanine + O2
?
show the reaction diagram
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-
-
?
anthranilic acid + alanine + O2
catechol + CO2 + NH3 + ?
show the reaction diagram
involved in the tryptophan degradation pathway
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-
?
anthranilic acid + NAD(P)H + O2 + H2O
catechol + CO2 + NAD(P)+ + NH3
show the reaction diagram
benzoate + NAD(P)H + O2 + H2O
benzoate dihydrodiol + ?
show the reaction diagram
poor substrate
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-
?
salicylic acid + NAD(P)H + O2 + H2O
?
show the reaction diagram
-
-
-
?
anthranilic acid + alanine + O2
?
show the reaction diagram
-
-
-
?
anthranilic acid + alanine + O2
catechol + CO2 + NH3 + ?
show the reaction diagram
involved in the tryptophan degradation pathway
-
-
?
anthranilic acid + NAD(P)H + O2 + H2O
catechol + CO2 + NAD(P)+ + NH3
show the reaction diagram
benzoate + NAD(P)H + O2 + H2O
benzoate dihydrodiol + ?
show the reaction diagram
poor substrate
-
-
?
salicylic acid + NAD(P)H + O2 + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
anthranilic acid + alanine + O2
catechol + CO2 + NH3 + ?
show the reaction diagram
involved in the tryptophan degradation pathway
-
-
?
anthranilic acid + NAD(P)H + O2 + H2O
catechol + CO2 + NAD(P)+ + NH3
show the reaction diagram
involved in the tryptophan degradation pathway
-
-
?
anthranilic acid + alanine + O2
catechol + CO2 + NH3 + ?
show the reaction diagram
involved in the tryptophan degradation pathway
-
-
?
anthranilic acid + NAD(P)H + O2 + H2O
catechol + CO2 + NAD(P)+ + NH3
show the reaction diagram
involved in the tryptophan degradation pathway
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iron-sulfur centre
proximal Rieske [2Fe-2S] center
iron-sulfur centre
proximal Rieske [2Fe-2S] center
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
large subunit; three component type of enzyme
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ANDAC_BURCE
423
0
48049
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
18900
AndAd, product of ORF4, calculated from deduced amino acid sequence
48000
AndAc, product of ORF3, calculated from deduced amino acid sequence
18900
AndAd, product of ORF4, calculated from deduced amino acid sequence
48000
AndAc, product of ORF3, calculated from deduced amino acid sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli TOP10F'
expressed in Escherichia coli TOP10F'
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chang, H.K.; Mohseni, P.; Zylstra, G.J.
Characterization and regulation of the genes for a novel anthranilate 1,2-dioxygenase from Burkholderia cepacia DBO1
J. Bacteriol.
185
5871-5881
2003
Burkholderia cepacia (Q84BZ2), Burkholderia cepacia (Q84BZ3), Burkholderia cepacia, Burkholderia cepacia DBO1 / ATCC 29424 (Q84BZ2), Burkholderia cepacia DBO1 / ATCC 29424 (Q84BZ3)
Manually annotated by BRENDA team