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Information on EC 1.14.11.B19 - [histone H3]-trimethyl-L-lysine56 demethylase and Organism(s) Homo sapiens and UniProt Accession B2RXH2

for references in articles please use BRENDA:EC1.14.11.B19
preliminary BRENDA-supplied EC number
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This record set is specific for:
Homo sapiens
UNIPROT: B2RXH2 not found.
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine56
+
3
+
3
=
a [histone H3]-L-lysine56
+
3
+
3
+
3
Synonyms
kdm4dl, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lysine-specific demethylase 4E
-
SYSTEMATIC NAME
IUBMB Comments
[histone H3]-N6,N6,N6-trimethyl-L-lysine56,2-oxoglutarate:oxygen oxidoreductase
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2
[histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2
[histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
-
?
additional information
?
-
trimethylation of H3K56 is removed by members of the JMJD2 family of demethylases that also target H3K9me3, reaction of EC 1.14.11.65
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cf. EC 1.14.11.65
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low expression level
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
predominant expression
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
overexpression of human KDM4E strongly diminishes [histone H3]-N6,N6,N6-trimethyl-L-lysine9, as well as [histone H3]-N6,N6,N6-trimethyl-L-lysine56 signals, in HeLa Kyoto cells. The loss of the respective trimethyl signal is accompanied with an increase in the monomethyl, but not dimethyl state. the activity is dependent on the enzymatic active jmjC domain
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KDM4E_HUMAN
506
0
56804
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jack, A.P.M.; Bussemer, S.; Hahn, M.; Pnzeler, S.; Snyder, M.; Wells, M.; Csankovszki, G.; Solovei, I.; Schotta, G.; Hake, S.B.
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization
PLoS ONE
8
e51765
2013
Homo sapiens (B2RXH2), Mus musculus (Q3U2K5)
Manually annotated by BRENDA team