Any feedback?
No. of entries
Information on EC 1.14.11.80 - methylcytosine dioxygenase
for references in articles please use BRENDA:EC1.14.11.80
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 1 Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
1.14.11.80 methylcytosine dioxygenase
IUBMB Comments
The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
show+
+
=
5-hydroxymethylcytosine in DNA
+
+
5-hydroxymethylcytosine in DNA
+
+
=
5-formylcytosine in DNA
+
+
+
5-formylcytosine in DNA
+
+
=
5-carboxycytosine in DNA
+
+
Synonyms
5-methylcytosine dioxygenase, DNA methylcytosine dioxygenase, ten eleven translocation, ten-eleven translocase-2, Ten-eleven translocation, Ten-eleven translocation 2, ten-eleven translocation dioxygenase, Ten-eleven translocation protein, ten-eleven-translocation 2, ten-eleven-translocation-2, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Ten-eleven translocation
TET1
TET2
TET3
TET1
-
-
-
-
TET2
-
-
-
-
TET3
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
5-formylcytosine in DNA + 2-oxoglutarate + O2 = 5-carboxycytosine in DNA + succinate + CO2
(3)
-
-
-
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2 = 5-formylcytosine in DNA + succinate + CO2 + H2O
(2)
-
-
-
5-methylcytosine in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine in DNA + succinate + CO2
(1)
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
5-methylcytosine in DNA,2-oxoglutarate:oxygen oxidoreductase
The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: isoform TET2 shows stronger binding to 5-methylcytosine over 5-hydroxymethylcytosine and 5-formylcytosine
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
-
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: the enzyme shows a preference for 5-methylcytosine-guanine mismatch in DNA as substrate. Replacing the 3'-guanine with adenine, thymine or cytosine results in reduction of the rate of 5-methylcytosine conversion by a factor of about 1.75, 3.8 and 5.8, respectively
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-formylcytosine in DNA + 2-oxoglutarate + O2
5-carboxycytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2
5-formylcytosine in DNA + succinate + CO2 + H2O
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: isoform TET2 shows stronger binding to 5-methylcytosine over 5-hydroxymethylcytosine and 5-formylcytosine
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
-
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
D0VLQ4
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
5-methylcytosine in DNA + 2-oxoglutarate + O2
5-hydroxymethylcytosine in DNA + succinate + CO2
Substrates: -
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe2+
Fe2+
0.075 mM ammonium iron(II) sulfate is used in optimized assay conditions
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-hydroxyglutarate
competitive inhibitor; competitive inhibitor; competitive inhibitor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ascorbate
ascorbate (0.0001-1 mM) significantly and specifically enhances enzyme-mediated generation of 5-hydroxymethylcytosine to 4fold above basal levels
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
D0VLQ4
knockdown of Tet1 in preimplantation embryos results in a bias towards trophectoderm differentiation. Tet1 knockdown prevents embryonic cell specification towards the ICM
malfunction
deletion of the Tet2 gene in T cells decreases their cytokine expression, associated with reduced p300 recruitment
malfunction
-
somatic isoform TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes, including chronic myelomonocytic leukemia, and acute myeloid leukemia
physiological function
D0VLQ4
Tet1 plays an important role in mouse embryonic stem cell maintenance through maintaining the expression of Nanog. Tet1 plays a role in regulating DNA methylation status
physiological function
enzyme form tet2 maintains GnRH peptide neuronal function and neuroendocrine control of male reproduction
physiological function
Tet proteins are crucial for diverse biological processes, including zygotic epigenetic reprogramming, pluripotent stem cell differentiation, hematopoiesis, and development of leukemia
physiological function
isoform Tet2 is one of the major tumor suppressors within the hematopoietic system. The enzyme sustains the immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression
physiological function
in vivo, isoform Tet2 plays a critical role in the control of cytokine gene expression in autoimmune disease. Isoform Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
Show AA Sequence and Transmembrane Helices (3734 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PDB
SCOP
CATH
UNIPROT
ORGANISM
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme complexed with DNA containing a 5-methylcytosine-guanine mismatch site, sitting drop vapor diffusion method, using 2 M ammonium sulfate, 0.1 M Bis-Tris-HCl, pH 5.4-5.6
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
D234A
the mutation results in almost complete reduction of 5-methylcytosine conversion compared to the wild type enzyme
D234N
the mutation results in about 80% reduction of 5-methylcytosine conversion compared to the wild type enzyme
H297N
the mutation results in about 70% reduction of 5-methylcytosine conversion compared to the wild type enzyme
H297Q
the mutation results in about 50% reduction of 5-methylcytosine conversion compared to the wild type enzyme
N147D
the mutation results in about 50% reduction of 5-methylcytosine conversion compared to the wild type enzyme
Q310A
the mutation results in about 60% reduction of 5-methylcytosine conversion compared to the wild type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
nickel-charged chelating column chromatography, HiTrap Q column chromatography, SP column chromatography, and Superdex 75 gel filtration
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme tet2 expression increases with age in the developing mouse preoptic area-hypothalamus and is substantially higher in a mature than an immature GnRH cell line. Enzyme tet2 expression increases in male and female mice between postnatal day 15 and 25
isoform Tet2 expression is increased in intratumoral myeloid cells by interleukin-1 receptor signaling
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
isoform TET2 mutations have a poor prognostic impact on the survival of patients with acute myeloid leukemia
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, L.; Lu, X.; Lu, J.; Liang, H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.; He, C.
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
Nat. Chem. Biol.
8
328-330
2012
Mus musculus (Q8BG87), Mus musculus (Q3URK3), Mus musculus (Q4JK59)
brenda
Taka, N.; Yoshida, W.
Quantification of global DNA methylation level using 5-methylcytosine dioxygenase
Anal. Bioanal. Chem.
412
5299-5305
2020
Homo sapiens (Q6N021)
brenda
Kurian, J.R.; Louis, S.; Keen, K.L.; Wolfe, A.; Terasawa, E.; Levine, J.E.
The methylcytosine dioxygenase ten-eleven translocase-2 (tet2) enables elevated GnRH gene expression and maintenance of male reproductive function
Endocrinology
157
3588-3603
2016
Mus musculus (Q4JK59)
brenda
Wu, H.; Zhang, Y.
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Genes Dev.
25
2436-2452
2011
Mus musculus (Q8BG87), Mus musculus (D0VLQ4), Mus musculus (D0VLQ5)
brenda
Ichiyama, K.; Chen, T.; Wang, X.; Yan, X.; Kim, B.S.; Tanaka, S.; Ndiaye-Lobry, D.; Deng, Y.; Zou, Y.; Zheng, P.; Tian, Q.; Aifantis, I.; Wei, L.; Dong, C.
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
Immunity
42
613-626
2015
Mus musculus (Q4JK59)
brenda
Pan, W.; Zhu, S.; Qu, K.; Meeth, K.; Cheng, J.; He, K.; Ma, H.; Liao, Y.; Wen, X.; Roden, C.; Tobiasova, Z.; Wei, Z.; Zhao, J.; Liu, J.; Zheng, J.; Guo, B.; Khan, S.A.; Bosenberg, M.; Flavell, R.A.; Lu, J.
The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression
Immunity
47
284-297.e5
2017
Mus musculus (Q4JK59)
brenda
Maiti, A.; Drohat, A.
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine Potential implications for active demethylation of CpG sites
J. Biol. Chem.
286
35334-35338
2011
Homo sapiens (O43151), Homo sapiens (Q6N021), Homo sapiens (Q8NFU7)
brenda
Minor, E.A.; Court, B.L.; Young, J.I.; Wang, G.
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
J. Biol. Chem.
288
13669-13674
2013
Mus musculus (Q8BG87), Mus musculus (Q3URK3), Mus musculus (Q4JK59)
brenda
Liu, W.J.; Tan, X.H.; Luo, X.P.; Guo, B.P.; Wei, Z.J.; Ke, Q.; He, S.; Cen, H.
Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutations in adult patients with acute myeloid leukemia a meta-analysis
Leuk. Lymphoma
55
2691-2698
2014
Homo sapiens
brenda
Liu, M.; Denizio, J.; Kohli, R.
Quantification of oxidized 5-methylcytosine bases and TET enzyme activity
Methods Enzymol.
573
365-385
2016
Homo sapiens (O43151), Homo sapiens (Q6N021), Homo sapiens (Q8NFU7)
brenda
Ito, S.; Dalessio, A.; Taranova, O.; Hong, K.; Sowers, L.; Zhang, Y.
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
Nature
466
1129-1133
2010
Mus musculus (D0VLQ4)
brenda
Hashimoto, H.; Pais, J.E.; Zhang, X.; Saleh, L.; Fu, Z.Q.; Dai, N.; Correa, I.R.; Zheng, Y.; Cheng, X.
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
Nature
506
391-395
2014
Naegleria gruberi (D2W6T1)
brenda
Lu, J.; Hu, L.; Cheng, J.; Fang, D.; Wang, C.; Yu, K.; Jiang, H.; Cui, Q.; Xu, Y.; Luo, C.
A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2)
Phys. Chem. Chem. Phys.
18
4728-4738
2016
Homo sapiens (Q6N021)
brenda
Ito, S.; Shen, L.; Dai, Q.; Wu, S.; Collins, L.; Swenberg, J.; He, C.; Zhang, Y.
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Science
333
1300-1303
2011
Mus musculus (Q8BG87), Mus musculus (Q3URK3), Mus musculus (Q4JK59)
brenda
EXTERNAL LINKS (specific for EC-Number 1.14.11.80)
html completed
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
