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Adenocarcinoma
Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma.
Adenocarcinoma of Lung
Histone demethylase KDM5A enhances cell proliferation, induces EMT in lung adenocarcinoma cells, and have a strong causal association with paclitaxel resistance.
African Swine Fever
An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1.
Aortic Valve Stenosis
Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program.
Ataxia
A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report.
Breast Neoplasms
A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.
Breast Neoplasms
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
Breast Neoplasms
A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo.
Breast Neoplasms
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448.
Breast Neoplasms
Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
Breast Neoplasms
Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer.
Breast Neoplasms
Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
Breast Neoplasms
Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B.
Breast Neoplasms
Expression of ANRIL-Polycomb Complexes-CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value.
Breast Neoplasms
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Breast Neoplasms
FBXL10 promotes ERR? protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERR?.
Breast Neoplasms
Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.
Breast Neoplasms
Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer.
Breast Neoplasms
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.
Breast Neoplasms
Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.
Breast Neoplasms
Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen.
Breast Neoplasms
Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast.
Breast Neoplasms
Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Breast Neoplasms
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Breast Neoplasms
JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer.
Breast Neoplasms
JARID1B is a luminal lineage-driving oncogene in breast cancer.
Breast Neoplasms
JARID1B modulates breast cancer cell apoptosis by regulating p53 expression.
Breast Neoplasms
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Breast Neoplasms
KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming.
Breast Neoplasms
Long noncoding RNA RHPN1-AS1, induced by KDM5B, is involved in breast cancer via sponging miR-6884-5p.
Breast Neoplasms
Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.
Breast Neoplasms
MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.
Breast Neoplasms
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.
Breast Neoplasms
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
Breast Neoplasms
PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
Breast Neoplasms
PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.
Breast Neoplasms
Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
Breast Neoplasms
Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer.
Breast Neoplasms
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Breast Neoplasms
Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.
Breast Neoplasms
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines.
Breast Neoplasms
T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients.
Breast Neoplasms
The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis.
Breast Neoplasms
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Breast Neoplasms
Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer.
Breast Neoplasms
Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes.
Bronchiolitis
Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis.
Carcinogenesis
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Carcinogenesis
Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer.
Carcinogenesis
FBXL10 promotes ERR? protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERR?.
Carcinogenesis
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Carcinogenesis
H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Carcinogenesis
Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3.
Carcinogenesis
Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein.
Carcinogenesis
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.
Carcinogenesis
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor.
Carcinogenesis
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo.
Carcinogenesis
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex.
Carcinogenesis
Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor.
Carcinogenesis
Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase.
Carcinogenesis
Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling.
Carcinogenesis
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Carcinogenesis
KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation.
Carcinogenesis
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
Carcinogenesis
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.
Carcinogenesis
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Carcinogenesis
Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency.
Carcinogenesis
MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.
Carcinogenesis
miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B.
Carcinogenesis
Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway.
Carcinogenesis
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Carcinogenesis
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Carcinogenesis
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.
Carcinogenesis
The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis.
Carcinogenesis
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Carcinogenesis
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Carcinoma
Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection.
Carcinoma
Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.
Carcinoma
Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer.
Carcinoma
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
Carcinoma
Epigenetic modifiers: activities in renal cell carcinoma.
Carcinoma
Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma.
Carcinoma
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).
Carcinoma
Genomic Alterations and Outcomes with VEGF-Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma
Genomic Landscape of Chinese Clear Cell Renal Cell Carcinoma Patients With Venous Tumor Thrombus Identifies Chromosome 9 and 14 Deletions and Related Immunosuppressive Microenvironment.
Carcinoma
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.
Carcinoma
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.
Carcinoma
KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck.
Carcinoma
Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma.
Carcinoma
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Carcinoma
LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma.
Carcinoma
microRNA-486-5p functions as a tumor suppressor in gastric carcinoma via directly targeting KDM5B.
Carcinoma
miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells.
Carcinoma
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer.
Carcinoma
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Carcinoma
Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.
Carcinoma
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Carcinoma
Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations.
Carcinoma
Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer.
Carcinoma
Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma.
Carcinoma
Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.
Carcinoma
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Carcinoma
[Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6].
Carcinoma, Ductal
Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer.
Carcinoma, Hepatocellular
Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27.
Carcinoma, Hepatocellular
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Carcinoma, Hepatocellular
Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.
Carcinoma, Hepatocellular
Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212.
Carcinoma, Hepatocellular
Increased Expression of Lysine-Specific Demethylase 5B (KDM5B) Promotes Tumor Cell Growth in Hep3B Cells and is an Independent Prognostic Factor in Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling.
Carcinoma, Hepatocellular
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Carcinoma, Hepatocellular
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression.
Carcinoma, Hepatocellular
MiR-22 regulated T cell differentiation and hepatocellular carcinoma growth by directly targeting Jarid2.
Carcinoma, Hepatocellular
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression.
Carcinoma, Non-Small-Cell Lung
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1.
Carcinoma, Non-Small-Cell Lung
Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1?-Suppression Mediated Methylation of PTEN.
Carcinoma, Non-Small-Cell Lung
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
Carcinoma, Ovarian Epithelial
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer.
Carcinoma, Renal Cell
Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
Carcinoma, Renal Cell
Epigenetic modifiers: activities in renal cell carcinoma.
Carcinoma, Renal Cell
Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).
Carcinoma, Renal Cell
Genomic Alterations and Outcomes with VEGF-Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.
Carcinoma, Renal Cell
Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Carcinoma, Renal Cell
Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations.
Carcinoma, Squamous Cell
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.
Carcinoma, Squamous Cell
KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Carcinoma, Squamous Cell
[Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6].
Cardiomyopathies
Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.
Cardiomyopathy, Dilated
Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice.
CHARGE Syndrome
Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.
Cholangiocarcinoma
KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma.
Cleft Lip
Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts.
Cleft Lip
Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate.
Cleft Lip
Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate.
Cleft Palate
Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts.
Cleft Palate
Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate.
Cleft Palate
Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate.
Colitis
MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2.
Colitis
MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2.
Coloboma
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Colonic Neoplasms
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
Colonic Neoplasms
JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.
Colonic Neoplasms
KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.
Colonic Neoplasms
KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis.
Colorectal Neoplasms
Depletion of JARID1B induces cellular senescence in human colorectal cancer.
Colorectal Neoplasms
JARID1B promotes colorectal cancer proliferation and Wnt/?-catenin signaling via decreasing CDX2 level.
Colorectal Neoplasms
Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/?-catenin pathway.
Dehydration
Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response.
Diabetic Cardiomyopathies
FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC ?2 pathway.
Diffuse Intrinsic Pontine Glioma
Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells.
Endometriosis
Peritoneal Modulators of EZH2-miR-155 Cross-Talk in Endometriosis.
Epilepsy
A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX.
Epilepsy
Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability.
Epilepsy
Variable Phenotypes of Epilepsy, Intellectual Disability, and Schizophrenia Caused by 12p13.33-p13.32 Terminal Microdeletion in a Korean Family: A Case Report and Literature Review.
Esophageal Neoplasms
Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth.
Esophageal Neoplasms
MicroRNA let-7i Inhibits Histone Lysine Demethylase KDM5B to Halt Esophageal Cancer Progression.
Esophageal Squamous Cell Carcinoma
Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection.
Esophageal Squamous Cell Carcinoma
LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells.
Esophageal Squamous Cell Carcinoma
Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.
Familial Primary Pulmonary Hypertension
Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
Glioblastoma
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1?-dependent pathway.
Glioblastoma
Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells.
Glioblastoma
Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells.
Glioblastoma
The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.
Glioma
Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1.
Glioma
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Glioma
Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Glioma
Reduced expression of Jumonji, AT-rich interactive domain 2 (JARID2) in glioma inhibits tumor growth in vitro and in vivo.
Glioma
SNHG1 promotes malignant biological behaviors of glioma cells via microRNA-154-5p/miR-376b-3p- FOXP2- KDM5B participating positive feedback loop.
Glioma
Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells.
Glioma
The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ).
Glioma
[Corrigendum] Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Head and Neck Neoplasms
KDM5 histone demethylases repress immune response via suppression of STING.
Heart Defects, Congenital
Epigenetic mechanisms in cardiac development and disease.
Heart Diseases
Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
Heart Failure
Comprehensive Myocardial Proteogenomics Profiling Reveals C/EBP? as the Key Factor in the Lipid Storage of ARVC.
Heart Failure
DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure.
Heart Failure
Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening.
Heart Septal Defects, Ventricular
Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
Hepatitis B
Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.
Hirschsprung Disease
KDM5B promotes cell migration by regulating the noncanonical Wnt/PCP pathway in Hirschsprung's disease.
Hyperglycemia
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Hyperglycinemia, Nonketotic
Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics.
Hypersensitivity
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Hypertension
Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
Hypertension
The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains.
Hypertension, Pulmonary
Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension via nuclear factor-kappa B (NFkB).
Infections
Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection.
Infections
Changes of host DNA methylation in domestic chickens infected with Salmonella enterica.
Infections
RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.
Infections
The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.
Insulin Resistance
The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.
Intellectual Disability
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
Intellectual Disability
A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability.
Intellectual Disability
A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report.
Intellectual Disability
A novel mutation in JARID1C gene associated with mental retardation.
Intellectual Disability
A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay.
Intellectual Disability
A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX.
Intellectual Disability
Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability.
Intellectual Disability
Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
Intellectual Disability
Different X-linked KDM5C Mutations in Affected Male Siblings: Is Maternal Reversion Error Involved?
Intellectual Disability
DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation.
Intellectual Disability
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance.
Intellectual Disability
Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability.
Intellectual Disability
Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
Intellectual Disability
Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics.
Intellectual Disability
JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome.
Intellectual Disability
KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature.
Intellectual Disability
Microdeletion of the escape genes KDM5C and IQSEC2 in a girl with severe intellectual disability and autistic features.
Intellectual Disability
Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome.
Intellectual Disability
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia.
Intellectual Disability
Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.
Intellectual Disability
Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.
Intellectual Disability
Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation.
Intellectual Disability
Novel human pathological mutations. Gene symbol: JARID1C. Disease: mental retardation, X-linked.
Intellectual Disability
Novel KDM5B splice variants identified in patients with developmental disorders: Functional consequences.
Intellectual Disability
Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.
Intellectual Disability
Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
Intellectual Disability
[Clinical features and gene variant of a pedigree affected with X-linked recessive mental retardation Claes-Jensen type].
Intellectual Disability
[Clinical phenotype and genetic analysis of a Chinese patient featuring X-linked Claes-Jensen type syndromic mental retardation].
Intellectual Disability
[Monogenic causes of X-linked mental retardation.]
Intellectual Disability
[Progress on X-linked mental retardation related gene JARID1C.]
Ischemic Stroke
Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis.
Kidney Neoplasms
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.
Klinefelter Syndrome
Epigenetics and genomics in Turner syndrome.
Laminopathies
Identification of Genes and Pathways Regulated by Lamin A in Heart.
Learning Disabilities
Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation.
Leukemia
Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.
Leukemia
Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions.
Leukemia
Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.
Leukemia
JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines.
Leukemia
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
Leukemia
Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Leukemia
Keeping methylation at bay.
Leukemia
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX-gene expression pattern.
Leukemia
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.
Leukemia
Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.
Leukemia
[Research Advances in Lysine-specific Demethylase 6A and Its Application in Treating Leukemia].
Leukemia
[The effects of JARID1B siRNA on proliferation and apoptosis in HL-60 cell].
Leukemia, Lymphoid
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
Leukemia, Megakaryoblastic, Acute
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX-gene expression pattern.
Leukemia, Monocytic, Acute
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions.
Leukemia, Myeloid, Acute
Identification and characterization of small molecule inhibitors of a plant homeodomain finger.
Leukemia, Myeloid, Acute
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Leukemia, Myeloid, Acute
Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view.
Leukemia, Myeloid, Acute
The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal.
Leukemia, Promyelocytic, Acute
[The effects of JARID1B siRNA on proliferation and apoptosis in HL-60 cell].
Liver Cirrhosis
Histone demethylase retinoblastoma binding protein 2 regulates the expression of ?-smooth muscle actin and vimentin in cirrhotic livers.
Liver Neoplasms
KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation.
Lung Neoplasms
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Lung Neoplasms
Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen.
Lung Neoplasms
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer.
Lung Neoplasms
JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression.
Lung Neoplasms
JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.
Lung Neoplasms
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1.
Lung Neoplasms
KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a.
Lung Neoplasms
Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer.
Lung Neoplasms
MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines.
Lung Neoplasms
Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells.
Lung Neoplasms
Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1?-Suppression Mediated Methylation of PTEN.
Lung Neoplasms
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer.
Lung Neoplasms
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
Lung Neoplasms
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Lung Neoplasms
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Lung Neoplasms
Y disruption, autosomal hypomethylation and poor male lung cancer survival.
Lymphatic Metastasis
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor.
Lymphatic Metastasis
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Lymphatic Metastasis
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Lymphoma
JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines.
Lymphoma
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.
Lymphoma, B-Cell
FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.
Lymphoma, Large B-Cell, Diffuse
FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.
Lymphoma, Mantle-Cell
JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines.
Medulloblastoma
OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
Melanoma
A role for the JARID1B stem cell marker for continuous melanoma growth.
Melanoma
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.
Melanoma
Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma?
Melanoma
Depletion of JARID1B induces cellular senescence in human colorectal cancer.
Melanoma
Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade.
Melanoma
Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.
Melanoma
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.
Melanoma
Humoral immune response against melanoma antigens induced by vaccination with cytokine gene-modified autologous tumor cells.
Melanoma
JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines.
Melanoma
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Melanoma
JARID1B protein expression and prognostic implications in uveal melanoma.
Melanoma
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.
Melanoma
Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth.
Melanoma
KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.
Melanoma
MicroRNA-363-3p/p21(Cip1/Waf1) axis is regulated by HIF-2? in mediating stemness of melanoma cells.
Melanoma
Phenformin enhances the efficacy of ERK inhibition in NF1-mutant melanoma.
Melanoma
Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.
Melanoma
Prognostic significance of RBP2-H1 variant of JARID1B in melanoma.
Melanoma
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Melanoma
Targeting the H3K4 Demethylase KDM5B Reprograms the Metabolome and Phenotype of Melanoma Cells.
Memory Disorders
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
Memory Disorders
Short-term memory deficits in carrier females with KDM5C mutations.
Mental Retardation, X-Linked
A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.
Mental Retardation, X-Linked
Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model.
Mental Retardation, X-Linked
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.
Mental Retardation, X-Linked
Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics.
Mental Retardation, X-Linked
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia.
Mental Retardation, X-Linked
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation.
Mental Retardation, X-Linked
Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease.
Mental Retardation, X-Linked
Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development.
Mental Retardation, X-Linked
Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate.
Mental Retardation, X-Linked
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.
Mental Retardation, X-Linked
X-linked mental retardation and severe short stature with a novel mutation of the KDM5C gene.
Mental Retardation, X-Linked
[Progress on X-linked mental retardation related gene JARID1C.]
Mental Retardation, X-Linked
[Two cases of X-linked mental retardation, Claes-Jensen syndrome caused by variation of KDM5C gene].
Microcephaly
Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics.
Microcephaly
[Monogenic causes of X-linked mental retardation.]
Mouth Neoplasms
Correction: JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.
Mouth Neoplasms
JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.
Movement Disorders
A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report.
Multiple Endocrine Neoplasia
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Multiple Endocrine Neoplasia Type 1
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Multiple Myeloma
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma.
Myelodysplastic Syndromes
Polycomb segment myeloid malignancies.
Myocardial Infarction
Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress.
Myocardial Ischemia
Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress.
Nasopharyngeal Carcinoma
FBXL10 contributes to the progression of nasopharyngeal carcinoma via involving in PI3K/mTOR pathway.
Nasopharyngeal Carcinoma
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion.
Nasopharyngeal Carcinoma
Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-181a retards nasopharyngeal carcinoma development by mediating KDM5C.
Neoplasm Metastasis
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448.
Neoplasm Metastasis
Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
Neoplasm Metastasis
Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma.
Neoplasm Metastasis
Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
Neoplasm Metastasis
ETV4 promotes the progression of gastric cancer through regulating KDM5D.
Neoplasm Metastasis
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Neoplasm Metastasis
Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma.
Neoplasm Metastasis
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor.
Neoplasm Metastasis
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.
Neoplasm Metastasis
Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1.
Neoplasm Metastasis
Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor.
Neoplasm Metastasis
Histone demethylase lysine demethylase 5B in development and cancer.
Neoplasm Metastasis
Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner.
Neoplasm Metastasis
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Neoplasm Metastasis
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Neoplasm Metastasis
JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
Neoplasm Metastasis
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.
Neoplasm Metastasis
JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling.
Neoplasm Metastasis
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.
Neoplasm Metastasis
KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance.
Neoplasm Metastasis
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.
Neoplasm Metastasis
KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming.
Neoplasm Metastasis
KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a.
Neoplasm Metastasis
KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma.
Neoplasm Metastasis
KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male.
Neoplasm Metastasis
Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia.
Neoplasm Metastasis
Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1.
Neoplasm Metastasis
LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT.
Neoplasm Metastasis
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression.
Neoplasm Metastasis
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Neoplasm Metastasis
Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.
Neoplasm Metastasis
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines.
Neoplasm Metastasis
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Neoplasms
A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.
Neoplasms
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
Neoplasms
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Neoplasms
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.
Neoplasms
Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448.
Neoplasms
Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.
Neoplasms
Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression.
Neoplasms
Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma?
Neoplasms
Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression.
Neoplasms
Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial.
Neoplasms
ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.
Neoplasms
Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
Neoplasms
Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection.
Neoplasms
Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer.
Neoplasms
Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
Neoplasms
Characterizing recurrent and lethal small renal masses in clear cell renal cell carcinoma using recurrent somatic mutations.
Neoplasms
cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases.
Neoplasms
Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence.
Neoplasms
Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer.
Neoplasms
Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.
Neoplasms
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
Neoplasms
Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.
Neoplasms
Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27.
Neoplasms
Depletion of JARID1B induces cellular senescence in human colorectal cancer.
Neoplasms
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5?C Degraders.
Neoplasms
Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).
Neoplasms
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the
Neoplasms
Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes.
Neoplasms
Endometrial cancer with an EML4-ALK rearrangement.
Neoplasms
Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.
Neoplasms
Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression.
Neoplasms
Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade.
Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Neoplasms
Epigenetic modifiers: activities in renal cell carcinoma.
Neoplasms
Epigenetic regulation in RCC: opportunities for therapeutic intervention?
Neoplasms
Evaluation of histone-modifying enzymes in stem cell populations.
Neoplasms
Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer.
Neoplasms
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Neoplasms
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer.
Neoplasms
Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer.
Neoplasms
Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma.
Neoplasms
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Neoplasms
F-box protein 10, an NF-?B-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway.
Neoplasms
FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.
Neoplasms
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.
Neoplasms
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).
Neoplasms
Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA.
Neoplasms
Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer.
Neoplasms
Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection.
Neoplasms
Genomic Landscape of Chinese Clear Cell Renal Cell Carcinoma Patients With Venous Tumor Thrombus Identifies Chromosome 9 and 14 Deletions and Related Immunosuppressive Microenvironment.
Neoplasms
Genomically annotated risk model for advanced renal-cell carcinoma: a retrospective cohort study.
Neoplasms
Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells.
Neoplasms
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.
Neoplasms
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation, in part, via transcriptional repression of histone H3 lysine 4 demethylases.
Neoplasms
Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3.
Neoplasms
Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein.
Neoplasms
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.
Neoplasms
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor.
Neoplasms
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.
Neoplasms
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.
Neoplasms
Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1.
Neoplasms
Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor.
Neoplasms
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy.
Neoplasms
Histone demethylase lysine demethylase 5B in development and cancer.
Neoplasms
Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/?-catenin signaling pathway.
Neoplasms
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.
Neoplasms
Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway.
Neoplasms
Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.
Neoplasms
Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-181a retards nasopharyngeal carcinoma development by mediating KDM5C.
Neoplasms
Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase.
Neoplasms
Identification of Genes and Pathways Regulated by Lamin A in Heart.
Neoplasms
Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen.
Neoplasms
Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast.
Neoplasms
Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications.
Neoplasms
In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.
Neoplasms
Increased Expression of Lysine-Specific Demethylase 5B (KDM5B) Promotes Tumor Cell Growth in Hep3B Cells and is an Independent Prognostic Factor in Patients with Hepatocellular Carcinoma.
Neoplasms
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.
Neoplasms
Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2+ Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression.
Neoplasms
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Neoplasms
Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy.
Neoplasms
JARID1 Histone Demethylases: Emerging Targets in Cancer.
Neoplasms
JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines.
Neoplasms
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Neoplasms
JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells.
Neoplasms
JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression.
Neoplasms
JARID1B promotes colorectal cancer proliferation and Wnt/?-catenin signaling via decreasing CDX2 level.
Neoplasms
JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells.
Neoplasms
JARID1B protein expression and prognostic implications in uveal melanoma.
Neoplasms
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.
Neoplasms
JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells.
Neoplasms
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
Neoplasms
JARID2 Is a Tumor Suppressor in Myeloid Neoplasms.
Neoplasms
Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer.
Neoplasms
JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling.
Neoplasms
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1.
Neoplasms
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Neoplasms
Jumonji AT-rich interactive domain 1B promotes the growth of pancreatic tumors via the phosphatase and tensin homolog/protein kinase B signaling pathway.
Neoplasms
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.
Neoplasms
Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e.
Neoplasms
Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth.
Neoplasms
KDM5 histone demethylases repress immune response via suppression of STING.
Neoplasms
KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.
Neoplasms
KDM5A Regulates a Translational Program that Controls p53 Protein Expression.
Neoplasms
KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation.
Neoplasms
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.
Neoplasms
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.
Neoplasms
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.
Neoplasms
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
Neoplasms
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.
Neoplasms
KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming.
Neoplasms
KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis.
Neoplasms
KDM5B-mediated microRNA-448 up-regulation restrains papillary thyroid cancer cell progression and slows down tumor growth via TGIF1 repression.
Neoplasms
KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a.
Neoplasms
KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.
Neoplasms
KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy.
Neoplasms
KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma.
Neoplasms
KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male.
Neoplasms
LncRNA TNK2-AS1/miR-125a-5p axis promotes tumor growth and modulated PI3K/AKT pathway.
Neoplasms
Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer.
Neoplasms
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Neoplasms
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Neoplasms
LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT.
Neoplasms
LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma.
Neoplasms
Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target.
Neoplasms
Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/?-catenin pathway.
Neoplasms
Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma.
Neoplasms
Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma.
Neoplasms
Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression.
Neoplasms
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.
Neoplasms
MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines.
Neoplasms
Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.
Neoplasms
Metastatic renal cell carcinoma without evidence of a renal primary.
Neoplasms
Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells.
Neoplasms
microRNA-139-3p Inhibits Malignant Behaviors of Laryngeal Cancer Cells via the KDM5B/SOX2 Axis and the Wnt/?-Catenin Pathway.
Neoplasms
microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C.
Neoplasms
microRNA-206 Suppresses Cholangiocarcinoma Cell Growth and Invasion by Targeting Jumonji AT-Rich Interactive Domain 2.
Neoplasms
microRNA-486-5p functions as a tumor suppressor in gastric carcinoma via directly targeting KDM5B.
Neoplasms
miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B.
Neoplasms
MiR-29a suppresses prostate cell proliferation and induces apoptosis via KDM5B protein regulation.
Neoplasms
MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.
Neoplasms
miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis.
Neoplasms
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
Neoplasms
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Neoplasms
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma.
Neoplasms
New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein.
Neoplasms
Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Neoplasms
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer.
Neoplasms
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Neoplasms
Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma.
Neoplasms
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Neoplasms
p21WAF-1 reorganizes the nucleus in tumor suppression.
Neoplasms
Personalized Survival Prediction of Patients With Acute Myeloblastic Leukemia Using Gene Expression Profiling.
Neoplasms
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.
Neoplasms
Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development.
Neoplasms
PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
Neoplasms
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
Neoplasms
PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
Neoplasms
PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.
Neoplasms
PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.
Neoplasms
Polycomb segment myeloid malignancies.
Neoplasms
Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer.
Neoplasms
Prediction of High-Grade Clear Cell Renal Cell Carcinoma Based on Plasma mRNA Profiles in Patients with Localized Pathologic T1N0M0 Stage Disease.
Neoplasms
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer.
Neoplasms
Prognostic significance of RBP2-H1 variant of JARID1B in melanoma.
Neoplasms
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Neoplasms
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia.
Neoplasms
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A.
Neoplasms
Reduced expression of Jumonji, AT-rich interactive domain 2 (JARID2) in glioma inhibits tumor growth in vitro and in vivo.
Neoplasms
Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer.
Neoplasms
Reticuloendotheliosis virus strain T induces miR-155 which targets JARID2 and promotes cell survival.
Neoplasms
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
Neoplasms
Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.
Neoplasms
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Neoplasms
Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma.
Neoplasms
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.
Neoplasms
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines.
Neoplasms
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.
Neoplasms
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Neoplasms
Targeting histone demethylase KDM5B for cancer treatment.
Neoplasms
Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view.
Neoplasms
Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.
Neoplasms
Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer.
Neoplasms
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Neoplasms
The emerging role of KDM5A in human cancer.
Neoplasms
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation.
Neoplasms
The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis.
Neoplasms
The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling.
Neoplasms
The KDM5 family of histone demethylases as targets in oncology drug discovery.
Neoplasms
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Neoplasms
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
Neoplasms
The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Neoplasms
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Neoplasms
The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer.
Neoplasms
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.
Neoplasms
Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types.
Neoplasms
Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile.
Neoplasms
Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer.
Neoplasms
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.
Neoplasms
Y disruption, autosomal hypomethylation and poor male lung cancer survival.
Neoplasms
[Application of human adipose-derived stromal cells in bone tissue engineering].
Neoplasms, Squamous Cell
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Neural Tube Defects
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Neural Tube Defects
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.
Neuroblastoma
Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein.
Neuroblastoma
JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells.
Neuroblastoma
Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma.
Neuroblastoma
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.
Neuroblastoma
Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.
Nevus
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Osteopetrosis
Diversity of copy number variation in the worldwide goat population.
Osteoporosis
KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.
Osteosarcoma
Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3.
Osteosarcoma
Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor.
Ovarian Neoplasms
KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance.
Ovarian Neoplasms
Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway.
Ovarian Neoplasms
Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance.
Ovarian Neoplasms
MiR-135b-5p affected malignant behaviors of ovarian cancer cells by targeting KDM5B.
Ovarian Neoplasms
miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer.
Ovarian Neoplasms
Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation.
Ovarian Neoplasms
Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells.
Pancreatic Neoplasms
Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells.
Papilloma
KDM5 histone demethylases repress immune response via suppression of STING.
Persistent Infection
Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection.
Pinealoma
Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.
Pre-Eclampsia
Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia.
Pre-Eclampsia
Redox-Sensitive Transcription Factor NRF2 Enhances Trophoblast Differentiation via Induction of miR-1246 and Aromatase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Down-regulation of JARID1B expression inhibits cell proliferation, induces apoptosis and blocks cell cycle in human acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
MiR-137 inhibits cell proliferation in acute lymphoblastic leukemia by targeting JARID1B.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.
Prostatic Neoplasms
Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression.
Prostatic Neoplasms
AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer.
Prostatic Neoplasms
Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression.
Prostatic Neoplasms
ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.
Prostatic Neoplasms
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5?C Degraders.
Prostatic Neoplasms
Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer.
Prostatic Neoplasms
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Prostatic Neoplasms
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy.
Prostatic Neoplasms
Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen.
Prostatic Neoplasms
Investigation of Histone Lysine-Specific Demethylase 5D KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach.
Prostatic Neoplasms
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.
Prostatic Neoplasms
JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
Prostatic Neoplasms
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
Prostatic Neoplasms
KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy.
Prostatic Neoplasms
KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN.
Prostatic Neoplasms
Re: Resistance to Docetaxel in Prostate Cancer is Associated with Androgen Receptor Activation and Loss of KDM5D Expression.
Prostatic Neoplasms
Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.
Prostatic Neoplasms
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.
Prostatic Neoplasms
Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer.
Prostatic Neoplasms
Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145).
Reflex, Abnormal
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia.
Renal Insufficiency
The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice.
Reperfusion Injury
Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress.
Respiratory Insufficiency
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.
Retinoblastoma
A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis.
Retinoblastoma
A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2.
Retinoblastoma
An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1.
Retinoblastoma
Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
Retinoblastoma
Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.
Retinoblastoma
Crosstalk between VEGF and novel angiogenic protein regulates tumor angiogenesis and contributes to aggressiveness of breast carcinoma.
Retinoblastoma
Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.
Retinoblastoma
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.
Retinoblastoma
Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
Retinoblastoma
Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212.
Retinoblastoma
Histone demethylase retinoblastoma binding protein 2 regulates the expression of ?-smooth muscle actin and vimentin in cirrhotic livers.
Retinoblastoma
Identification of Genes and Pathways Regulated by Lamin A in Heart.
Retinoblastoma
Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.
Retinoblastoma
Inhibition of osteogenic differentiation of human adipose-derived stromal cells by retinoblastoma binding protein 2 repression of RUNX2-activated transcription.
Retinoblastoma
Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).
Retinoblastoma
Isolation and regional assignment of human chromosome 12p cDNAs.
Retinoblastoma
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.
Retinoblastoma
JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle.
Retinoblastoma
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Retinoblastoma
MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2.
Retinoblastoma
MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network.
Retinoblastoma
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
Retinoblastoma
siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells.
Retinoblastoma
The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation.
Retinoblastoma
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Retinoblastoma
[Application of human adipose-derived stromal cells in bone tissue engineering].
Retinoblastoma
[Inhibition of retinoblastoma binding protein 2 promotes osteogenic differentiation of human adipose-derived stromal cells].
Rhabdomyosarcoma
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.
Sarcoma
In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC).
Sarcoma
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma.
Sarcoma, Ewing
KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma.
Seizures
Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability.
Sepsis
The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice.
Skin Neoplasms
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
Spondylitis, Ankylosing
JARID1A, JMY, and PTGER4 Polymorphisms Are Related to Ankylosing Spondylitis in Chinese Han Patients: A Case-Control Study.
Spondylitis, Ankylosing
The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection.
Squamous Cell Carcinoma of Head and Neck
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.
Squamous Cell Carcinoma of Head and Neck
[Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6].
Stomach Neoplasms
Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).
Stomach Neoplasms
ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
Stomach Neoplasms
Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression.
Stomach Neoplasms
ETV4 promotes the progression of gastric cancer through regulating KDM5D.
Stomach Neoplasms
Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
Stomach Neoplasms
Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
Stomach Neoplasms
Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212.
Stomach Neoplasms
Increased Mars2 expression upon microRNA-4661-5p-mediated KDM5D downregulation is correlated with malignant degree of gastric cancer cells.
Stomach Neoplasms
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.
Stomach Neoplasms
KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male.
Stomach Neoplasms
Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1.
Stomach Neoplasms
MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2.
Stomach Neoplasms
miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B.
Stomach Neoplasms
TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma.
Stroke
X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals.
Thyroid Cancer, Papillary
microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C.
Thyroid Cancer, Papillary
siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells.
Tics
Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer.
Triple Negative Breast Neoplasms
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.
Triple Negative Breast Neoplasms
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.
Triple Negative Breast Neoplasms
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Triple Negative Breast Neoplasms
Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer.
Urinary Bladder Neoplasms
Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer.
Urinary Bladder Neoplasms
Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling.
Urinary Bladder Neoplasms
Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer.
Urinary Bladder Neoplasms
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Uterine Cervical Neoplasms
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the
Uterine Cervical Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Uterine Cervical Neoplasms
HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway.
Uterine Cervical Neoplasms
Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway.
Uterine Cervical Neoplasms
miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway.
Virus Diseases
Genome-Wide Association Study Identifies Loci Associated with Resistance to Viral Nervous Necrosis Disease in Asian Seabass.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Histone demethylase KDM5B is a key regulator of genome stability.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Inactive yet indispensable: the tale of Jarid2.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Jarid2 regulates mouse epidermal stem cell activation and differentiation.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
[histone h3]-trimethyl-l-lysine4 demethylase deficiency
Y disruption, autosomal hypomethylation and poor male lung cancer survival.
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Yamane, K.; Tateishi, K.; Klose, R.J.; Fang, J.; Fabrizio, L.A.; Erdjument-Bromage, H.; Taylor-Papadimitriou, J.; Tempst, P.; Zhang, Y.
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
Mol. Cell
25
801-812
2007
Homo sapiens
brenda
Tahiliani, M.; Mei, P.; Fang, R.; Leonor, T.; Rutenberg, M.; Shimizu, F.; Li, J.; Rao, A.; Shi, Y.
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Nature
447
601-605
2007
Homo sapiens (P41229)
brenda
Xiang, Y.; Zhu, Z.; Han, G.; Ye, X.; Xu, B.; Peng, Z.; Ma, Y.; Yu, Y.; Lin, H.; Chen, A.P.; Chen, C.D.
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
Proc. Natl. Acad. Sci. USA
104
19226-19231
2007
Homo sapiens
brenda
Lopez-Bigas, N.; Kisiel, T.; DeWaal, D.; Holmes, K.; Volkert, T.; Gupta, S.; Love, J.; Murray, H.; Young, R.; Benevolenskaya, E.
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation
Mol. Cell
31
520-530
2008
Homo sapiens
brenda
Lee, J.; Thompson, J.; Botuyan, M.; Mer, G.
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor
Nat. Struct. Mol. Biol.
15
109-111
2008
Homo sapiens (O75164)
brenda
Zhou, W.; Chen, H.; Zhang, L.
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor
BMB Rep.
42
154-159
2009
Homo sapiens
brenda
Grafodatskaya, D.; Chung, B.H.; Butcher, D.T.; Turinsky, A.L.; Goodman, S.J.; Choufani, S.; Chen, Y.A.; Lou, Y.; Zhao, C.; Rajendram, R.; Abidi, F.E.; Skinner, C.; Stavropoulos, J.; Bondy, C.A.; Hamilton, J.; Wodak, S.; Scherer, S.W.; Schwartz, C.E.; Weksberg, R.
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
BMC Med. Genomics
6
0000
2013
Homo sapiens
brenda
El Mansouri, F.; Nebbaki, S.; Kapoor, M.; Afif, H.; Martel-Pelletier, J.; Pelletier, J.; Benderdour, M.; Fahmi, H.
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
Arthritis Res. Ther.
16
R113
2014
Homo sapiens (O60341), Homo sapiens
brenda
Maina, P.K.; Shao, P.; Jia, X.; Liu, Q.; Umesalma, S.; Marin, M.; Long, D.; Concepcion-Roman, S.; Qi, H.H.
Histone demethylase PHF8 regulates hypoxia signaling through HIF1alpha and H3K4me3
Biochim. Biophys. Acta
1860
1002-1012
2017
Homo sapiens
brenda
Tumber, A.; Nuzzi, A.; Hookway, E.S.; Hatch, S.B.; Velupillai, S.; Johansson, C.; Kawamura, A.; Savitsky, P.; Yapp, C.; Szykowska, A.; Wu, N.; Bountra, C.; Strain-Damerell, C.; Burgess-Brown, N.A.; Ruda, G.F.; Fedorov, O.; Munro, S.; England, K.S.; Nowak, R.P.; Schofield, C.J.; La Thangue, N.B.; Pawlyn, C.
Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells
Cell Chem. Biol.
24
371-380
2017
Homo sapiens (P29375), Homo sapiens (P41229), Homo sapiens (Q9BY66), Homo sapiens (Q9UGL1)
brenda
Klein, B.J.; Piao, L.; Xi, Y.; Rincon-Arano, H.; Rothbart, S.B.; Peng, D.; Wen, H.; Larson, C.; Zhang, X.; Zheng, X.; Cortazar, M.A.; Pena, P.V.; Mangan, A.; Bentley, D.L.; Strahl, B.D.; Groudine, M.; Li, W.; Shi, X.; Kutateladze, T.G.
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers
Cell Rep.
6
325-335
2014
Homo sapiens (Q9UGL1)
brenda
Nishibuchi, G.; Shibata, Y.; Hayakawa, T.; Hayakawa, N.; Ohtani, Y.; Sinmyozu, K.; Tagami, H.; Nakayama, J.
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex
J. Biol. Chem.
289
28956-28970
2014
Homo sapiens (P29375), Caenorhabditis elegans (Q23541), Caenorhabditis elegans
brenda
Horton, J.R.; Engstrom, A.; Zoeller, E.L.; Liu, X.; Shanks, J.R.; Zhang, X.; Johns, M.A.; Vertino, P.M.; Fu, H.; Cheng, X.
Characterization of a linked Jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases
J. Biol. Chem.
291
2631-2646
2016
Homo sapiens (P29375), Homo sapiens (P41229), Homo sapiens (Q9UGL1)
brenda
Bavetsias, V.; Lanigan, R.M.; Ruda, G.F.; Atrash, B.; McLaughlin, M.G.; Tumber, A.; Mok, N.Y.; Le Bihan, Y.V.; Dempster, S.; Boxall, K.J.; Jeganathan, F.; Hatch, S.B.; Savitsky, P.; Velupillai, S.; Krojer, T.; England, K.S.; Sejberg, J.; Thai, C.; Donovan, A.; Pal, A.; Scozzafava, G.; Bennett, J.M.; Kawamu, A.
8-Substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors
J. Med. Chem.
59
1388-1409
2016
Homo sapiens (P41229), Homo sapiens (Q9UGL1)
brenda
Xiao, C.; Liu, Y.; Xie, C.; Tu, W.; Xia, Y.; Costa, M.; Zhou, X.
Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity
Toxicol. Sci.
145
80-89
2015
Homo sapiens (P29375), Homo sapiens
brenda
Kim, J.; Shin, S.; Subramaniam, M.; Bruinsma, E.; Kim, T.D.; Hawse, J.R.; Spelsberg, T.C.; Janknecht, R.
Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
Biochem. Biophys. Res. Commun.
401
412-416
2010
Homo sapiens
brenda
Iwase, S.; Lan, F.; Bayliss, P.; de la Torre-Ubieta, L.; Huarte, M.; Qi, H.H.; Whetstine, J.R.; Bonni, A.; Roberts, T.M.; Shi, Y.
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
Cell
128
1077-1088
2007
Homo sapiens
brenda
Enkhbaatar, Z.; Terashima, M.; Oktyabri, D.; Tange, S.; Ishimura, A.; Yano, S.; Suzuki, T.
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family
Cell Cycle
12
2100-2112
2013
Homo sapiens
brenda
Horton, J.R.; Woodcock, C.B.; Chen, Q.; Liu, X.; Zhang, X.; Shanks, J.; Rai, G.; Mott, B.T.; Jansen, D.J.; Kales, S.C.; Henderson, M.J.; Cyr, M.; Pohida, K.; Hu, X.; Shah, P.; Xu, X.; Jadhav, A.; Maloney, D.J.; Hall, M.D.; Simeonov, A.; Fu, H.; Vertino, P.M.; Cheng, X.
Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A
J. Med. Chem.
61
10588-10601
2018
Homo sapiens
brenda
Wong, P.P.; Miranda, F.; Chan, K.V.; Berlato, C.; Hurst, H.C.; Scibetta, A.G.
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21cip (CDKN1A)
Mol. Cell. Biol.
32
1633-1644
2012
Homo sapiens
brenda
Longbotham, J.; Chio, C.; Dharmarajan, V.; Trnka, M.; Torres, I.; Goswami, D.; Ruiz, K.; Burlingame, A.; Griffin, P.; Fujimori, D.
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
Nat. Commun.
10
94
2019
Homo sapiens
brenda
Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
Proc. Natl. Acad. Sci. USA
108
7541-7546
2011
Homo sapiens
brenda
Longbotham, J.E.; Kelly, M.J.S.; Fujimori, D.G.
Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A
ACS Chem. Biol.
FEHLT
0000
2021
Homo sapiens (P29375)
brenda
Xu, L.; Wu, H.; Hu, X.
Histone demethylase KDM5A enhances cell proliferation, induces EMT in lung adenocarcinoma cells, and have a strong causal association with paclitaxel resistance
Acta Biochim. Pol.
68
593-602
2021
Homo sapiens (P29375), Homo sapiens
brenda
Petronikolou, N.; Longbotham, J.E.; Fujimori, D.G.
Extended recognition of the histone H3 tail by histone demethylase KDM5A
Biochemistry
59
647-651
2020
Homo sapiens (P29375), Homo sapiens
brenda
Li, Q.M.; Li, J.L.; Feng, Z.H.; Lin, H.C.; Xu, Q.
Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells
Bioengineered
11
449-462
2020
Homo sapiens (P29375), Homo sapiens
brenda
Romani, M.; Daga, A.; Forlani, A.; Pistillo, M.P.; Banelli, B.
Targeting of histone demethylases KDM5A and KDM6B inhibits the proliferation of temozolomide-resistant glioblastoma cells
Cancers (Basel)
11
878
2019
Homo sapiens (P29375)
brenda
Zhao, B.; Liang, Q.; Ren, H.; Zhang, X.; Wu, Y.; Zhang, K.; Ma, L.; Zheng, Y.; Liu, H.
Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)
Eur. J. Med. Chem.
192
112161
2020
Homo sapiens (Q9UGL1)
brenda
Pippa, S.; Mannironi, C.; Licursi, V.; Bombardi, L.; Colotti, G.; Cundari, E.; Mollica, A.; Coluccia, A.; Naccarato, V.; La Regina, G.; Silvestri, R.; Negri, R.
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
Molecules
24
1739
2019
Homo sapiens (Q9UGL1)
brenda
Wu, L.; Cao, J.; Cai, W.; Lang, S.; Horton, J.; Jansen, D.; Liu, Z.; Chen, J.; Zhang, M.; Mott, B.; Pohida, K.; Rai, G.; Kales, S.; Henderson, M.; Hu, X.; Jadhav, A.; Maloney, D.; Simeonov, A.; Zhu, S.; Iwasaki, A.; Hall, M.; Cheng, X.; Shadel, G.; Yan, Q
KDM5 histone demethylases repress immune response via suppression of STING
PLoS Biol.
16
e2006134
2018
Homo sapiens (P41229), Homo sapiens (Q9UGL1), Homo sapiens
brenda
Dorosz, J.; Kristensen, L.H.; Aduri, N.G.; Mirza, O.; Lousen, R.; Bucciarelli, S.; Mehta, V.; Selles-Baiget, S.; Solbak, S.M.O.; Bach, A.; Mesa, P.; Hernandez, P.A.; Montoya, G.; Nguyen, T.T.T.N.; Rand, K.D.; Boesen, T.; Gajhede, M.
Molecular architecture of the Jumonji C family histone demethylase KDM5B
Sci. Rep.
9
4019
2019
Homo sapiens (Q9UGL1), Homo sapiens
brenda