Reference on EC 1.14.11.4 - procollagen-lysine 5-dioxygenase and Organism(s) Homo sapiens and UniProt Accession Q6NYC1
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kivirikko, K.I.; Myllyl, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Gallus gallus, Homo sapiens
Puistola, U.
Catalytic properties of lysyl hydroxylase from cells synthesizing genetically different collagen types
Biochem. J.
201
215-219
1982
Gallus gallus, Homo sapiens
Kellokumpu, S.; Sormunen, R.; Heikkinen, J.; Myllyla, R.
Lysyl hydroxylase, a collagen processing enzyme, exemplifies a novel class of luminally-oriented peripheral membrane proteins in the endoplasmic reticulum
J. Biol. Chem.
269
30524-30529
1994
Homo sapiens
Valtavaara, M.; Papponen, H.; Pirttilae, A.M.; Hiltunen, K.; Helander, H.; Myllylae, R.
Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle
J. Biol. Chem.
272
6831-6834
1997
Homo sapiens (O00469), Homo sapiens
Passoja, K.; Rautavuoma, K.; Ala-Kokko, L.; Kosonen, T.; Kivirikko, K.I.
Cloning and characterization of a third human lysyl hydroxylase isoform
Proc. Natl. Acad. Sci. USA
95
10482-10486
1998
Homo sapiens (O60568), Homo sapiens
Rautavuoma, K.; Takaluoma, K.; Passoja, K.; Pirskanen, A.; Kvist, A.P.; Kivirikko, K.I.; Myllyharju, J.
Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3: The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
J. Biol. Chem.
277
23084-23091
2002
Homo sapiens
Armstrong, L.C.; Last, J.A.
Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system
Biochim. Biophys. Acta
1264
93-102
1995
Gallus gallus, Homo sapiens, Rattus norvegicus (Q63321)
Suokas, M.; Lampela, O.; Juffer, A.H.; Myllyla, R.; Kellokumpu, S.
Retrieval-independent localization of lysyl hydroxylase in the endoplasmic reticulum via a peptide fold in its iron-binding domain
Biochem. J.
370
913-920
2003
Homo sapiens
van der Slot, A.J.; Zuurmond, A.M.; Bardoel, A.F.; Wijmenga, C.; Pruijs, H.E.; Sillence, D.O.; Brinckmann, J.; Abraham, D.J.; Black, C.M.; Verzijl, N.; DeGroot, J.; Hanemaaijer, R.; TeKoppele, J.M.; Huizinga, T.W.; Bank, R.A.
Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis
J. Biol. Chem.
278
40967-40972
2003
Homo sapiens (O00469), Homo sapiens
Risteli, M.; Niemitalo, O.; Lankinen, H.; Juffer, A.H.; Myllyla, R.
Characterization of collagenous peptides bound to lysyl hydroxylase isoforms
J. Biol. Chem.
279
37535-37543
2004
Caenorhabditis elegans, Homo sapiens
Walker, L.C.; Overstreet, M.A.; Siddiqui, A.; De Paepe, A.; Ceylaner, G.; Malfait, F.; Symoens, S.; Atsawasuwan, P.; Yamauchi, M.; Ceylaner, S.; Bank, R.A.; Yeowell, H.N.
A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an Ehlers-Danlos VIA patient
J. Invest. Dermatol.
124
914-918
2005
Homo sapiens
Walker, L.C.; Overstreet, M.A.; Yeowell, H.N.
Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts
Matrix Biol.
23
515-523
2005
Homo sapiens (O00469), Homo sapiens
Wu, J.; Reinhardt, D.P.; Batmunkh, C.; Lindenmaier, W.; Far, R.K.; Notbohm, H.; Hunzelmann, N.; Brinckmann, J.
Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts
Exp. Cell Res.
312
3485-3494
2006
Homo sapiens
Zuurmond, A.M.; van der Slot-Verhoeven, A.J.; van Dura, E.A.; De Groot, J.; Bank, R.A.
Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis
Matrix Biol.
24
261-270
2005
Homo sapiens
Takaluoma, K.; Lantto, J.; Myllyharju, J.
Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences
Matrix Biol.
26
396-403
2007
Homo sapiens
Salo, A.M.; Cox, H.; Farndon, P.; Moss, C.; Grindulis, H.; Risteli, M.; Robins, S.P.; Myllylae, R.
A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene
Am. J. Hum. Genet.
83
495-503
2008
Homo sapiens, Homo sapiens (O60568)
Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco
Biomacromolecules
10
2640-2645
2009
Homo sapiens
Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
J. Biol. Chem.
284
28204-28211
2009
Homo sapiens, Homo sapiens (O60568)
Hyry, M.; Lantto, J.; Myllyharju, J.
Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2
J. Biol. Chem.
284
30917-30924
2009
Homo sapiens
Wang, C.; Kovanen, V.; Raudasoja, P.; Eskelinen, S.; Pospiech, H.; Myllylae, R.
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
J. Cell. Mol. Med.
13
508-521
2009
Homo sapiens (O60568)
Yeowell, H.N.; Walker, L.C.; Mauger, D.M.; Seth, P.; Garcia-Blanco, M.A.
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2
J. Invest. Dermatol.
129
1402-1411
2009
Homo sapiens
Webby, C.J.; Wolf, A.; Gromak, N.; Dreger, M.; Kramer, H.; Kessler, B.; Nielsen, M.L.; Schmitz, C.; Butler, D.S.; Yates, J.R.; Delahunty, C.M.; Hahn, P.; Lengeling, A.; Mann, M.; Proudfoot, N.J.; Schofield, C.J.; Boettger, A.
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
Science
325
90-93
2009
Homo sapiens
Mantri, M.; Krojer, T.; Bagg, E.A.; Webby, C.J.; Butler, D.S.; Kochan, G.; Kavanagh, K.L.; Oppermann, U.; McDonough, M.A.; Schofield, C.J.
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
J. Mol. Biol.
401
211-222
2010
Homo sapiens (Q6NYC1)
Wang, C.; Ristiluoma, M.M.; Salo, A.M.; Eskelinen, S.; Myllylae, R.
Lysyl hydroxylase 3 is secreted from cells by two pathways
J. Cell. Physiol.
227
668-675
2012
Canis lupus familiaris, Homo sapiens (O60568), Canis lupus familiaris Madin-Darby
Remst, D.F.; Blaney Davidson, E.N.; Vitters, E.L.; Bank, R.A.; van den Berg, W.B.; van der Kraan, P.M.
TGF-beta induces lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling
Cell Tissue Res.
355
163-171
2013
Homo sapiens
Heikkinen, J.; Risteli, M.; Lampela, O.; Alavesa, P.; Karppinen, M.; Juffer, A.; Myllylae, R.
Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547
Matrix Biol.
30
27-33
2011
Homo sapiens
Mantri, M.; Webby, C.; Loik, N.; Hamed, R.; Nielsen, M.; McDonough, M.; McCullagh, J.; Boettger, A.; Schofield, C.; Wolf, A.
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
MedChemComm
3
80-85
2012
Homo sapiens
-
Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Mol. Cancer Res.
11
456-466
2013
Homo sapiens
Guo, H.F.; Cho, E.J.; Devkota, A.K.; Chen, Y.; Russell, W.; Phillips, G.N.; Yamauchi, M.; Dalby, K.N.; Kurie, J.M.
A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay
Arch. Biochem. Biophys.
618
45-51
2017
Homo sapiens (O00469), Homo sapiens
Dayer, C.; Stamenkovic, I.
Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation
J. Biol. Chem.
290
13763-13778
2015
Homo sapiens (O60568)
Gjaltema, R.A.; de Rond, S.; Rots, M.G.; Bank, R.A.
Procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor beta-1 activation mechanism
J. Biol. Chem.
290
28465-28476
2015
Homo sapiens (O00469)
Chen, Y.; Terajima, M.; Yang, Y.; Sun, L.; Ahn, Y.H.; Pankova, D.; Puperi, D.S.; Watanabe, T.; Kim, M.P.; Blackmon, S.H.; Rodriguez, J.; Liu, H.; Behrens, C.; Wistuba, I.I.; Minelli, R.; Scott, K.L.; Sanchez-Adams, J.; Guilak, F.; Pati, D.; Thilaganathan, N.; Burns, A.R.; Creighton, C.J.; Martinez, E.D.; Zal, T.; Allen, K.; Yamauchi, M.; Kurie, J.M.
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
J. Clin. Invest.
125
1147-1162
2015
Homo sapiens (O00469), Homo sapiens, Mus musculus (Q9R0B9), Mus musculus
Neyazi, B.; Tanrikulu, L.; Wilkens, L.; Hartmann, C.; Stein, K.P.; Dumitru, C.A.; Sandalcioglu, I.E.
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size
World Neurosurg.
102
79-84
2017
Homo sapiens (O00469), Homo sapiens
Scietti, L.; Chiapparino, A.; De Giorgi, F.; Fumagalli, M.; Khoriauli, L.; Nergadze, S.; Basu, S.; Olieric, V.; Cucca, L.; Banushi, B.; Profumo, A.; Giulotto, E.; Gissen, P.; Forneris, F.
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Nat. Commun.
9
3163
2018
Homo sapiens (O60568), Homo sapiens
Piersma, B.; Bank, R.A.
Collagen cross-linking mediated by lysyl hydroxylase 2 an enzymatic battlefield to combat fibrosis
Essays Biochem.
63
377-387
2019
Homo sapiens (O00469)
Gong, S.; Wu, C.; Koehler, F.; Meixensberger, J.; Schopow, N.; Kallendrusch, S.
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase family novel prognostic biomarkers and tumor microenvironment regulators for lower-grade glioma
Front. Cell. Neurosci.
16
838548
2022
Homo sapiens (O00469), Homo sapiens (O60568), Homo sapiens (Q02809)
Xu, Y.; Zhang, L.; Wei, Y.; Zhang, X.; Xu, R.; Han, M.; Huang, B.; Chen, A.; Li, W.; Zhang, Q.; Li, G.; Wang, J.; Zhao, P.; Li, X.
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion
Oncotarget
8
23401-23413
2017
Homo sapiens (O00469), Homo sapiens
