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(R,S)-canadine + 2-oxoglutarate + O2
?
-
a protoberberine, 32% of activity with oripavine
-
-
?
(R,S)-tetrahydropalmatine + 2-oxoglutarate + O2
?
-
a protoberberine, O-demethylation, below 1% of activity with oripavine
-
-
?
(R,S)-tetrahydropapaverine + 2-oxoglutarate + O2
?
-
a 1-benzylisoquinoline, O-demethylation, 2.1% of activity with oripavine
-
-
?
allocryptopine + 2-oxoglutarate + O2
?
-
a protopine, O-demethylation, 9.5% of activity with oripavine
-
-
?
cryptopine + 2-oxoglutarate + O2
?
-
a protopine, O-demethylation, below 1% of activity with oripavine
-
-
?
oripavine + 2-oxoglutarate + O2
?
-
a morphinan, best substrate
-
-
?
oripavine + 2-oxoglutarate + O2
morphinane + formaldehyde + succinate + CO2
-
-
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
papaverine + 2-oxoglutarate + O2
?
-
a 1-benzylisoquinoline,O-demethylation, below 1% of activity with oripavine
-
-
?
thebaine + 2-oxoglutarate + O2
codeinone + formaldehyde + succinate + CO2
-
-
-
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
additional information
?
-
oripavine + 2-oxoglutarate + O2

morphinone + formaldehyde + succinate + CO2
-
-
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
-
a step of morphine biosynthesis
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
-
alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde
-
-
?
thebaine + 2-oxoglutarate + O2

neopinone + formaldehyde + succinate + CO2
-
-
-
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
-
a step of morphine biosynthesis
spontaneous conversion to codeinone
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
-
85% of the activity with oripavine. Alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde
spontaneous conversion to codeinone
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
-
a morphinan, 97.2% of activity with oripavine
-
-
?
additional information

?
-
-
no activity with (S)-reticuline, (S)-scoulerine, papaverine, (S)-corytuberine, pavine, salutaridine, noscapine, codeine
-
-
?
additional information
?
-
-
when assayed with a wide range of benzylisoquinoline alkaloids, the enzyme shows efficient dealkylation activities, including regio- and substrate-specific O-demethylation and O,O-demethylenation, substrate specificity, overview. No or poor activity with (S)-reticuline, (S)-isocorydine, (S)-scoulerine, (R,S)-stylopine, berberine, O-demethylcryptopine, protopine, and codeine
-
-
?
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oripavine + 2-oxoglutarate + O2
morphinane + formaldehyde + succinate + CO2
-
-
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
thebaine + 2-oxoglutarate + O2
codeinone + formaldehyde + succinate + CO2
-
-
-
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
oripavine + 2-oxoglutarate + O2

morphinone + formaldehyde + succinate + CO2
-
-
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
-
a step of morphine biosynthesis
-
-
?
thebaine + 2-oxoglutarate + O2

neopinone + formaldehyde + succinate + CO2
-
-
-
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
-
a step of morphine biosynthesis
spontaneous conversion to codeinone
-
?
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DIOX1_PAPSO
364
0
40624
Swiss-Prot
other Location (Reliability: 3)
A0A072U060_MEDTR
370
0
42309
TrEMBL
other Location (Reliability: 4)
A0A396JBY5_MEDTR
384
0
44304
TrEMBL
other Location (Reliability: 5)
A0A2G9GHQ2_9LAMI
356
0
39749
TrEMBL
other Location (Reliability: 3)
A0A072UFL7_MEDTR
352
0
40073
TrEMBL
other Location (Reliability: 3)
A0A2P6Q562_ROSCH
310
0
35449
TrEMBL
other Location (Reliability: 2)
A0A396GMH7_MEDTR
365
0
41266
TrEMBL
other Location (Reliability: 5)
A0A396GPI6_MEDTR
86
0
9573
TrEMBL
other Location (Reliability: 4)
A0A2G9GZ15_9LAMI
97
0
11063
TrEMBL
other Location (Reliability: 4)
A0A2G9G071_9LAMI
177
0
20294
TrEMBL
other Location (Reliability: 2)
A0A396GMK1_MEDTR
62
0
6773
TrEMBL
other Location (Reliability: 3)
A0A2G9GYU2_9LAMI
358
0
40269
TrEMBL
other Location (Reliability: 2)
A0A2G9HXH5_9LAMI
352
0
39543
TrEMBL
other Location (Reliability: 3)
A0A396GME6_MEDTR
131
0
14765
TrEMBL
other Location (Reliability: 3)
A0A2G9GGH5_9LAMI
355
0
40034
TrEMBL
other Location (Reliability: 4)
A0A2G9GVE4_9LAMI
350
0
40260
TrEMBL
other Location (Reliability: 3)
A0A396GMQ9_MEDTR
371
0
42136
TrEMBL
other Location (Reliability: 4)
A0A396HYT1_MEDTR
379
0
43699
TrEMBL
Mitochondrion (Reliability: 3)
A0A396JDV8_MEDTR
334
0
38451
TrEMBL
other Location (Reliability: 3)
A0A072TJA3_MEDTR
261
0
29948
TrEMBL
other Location (Reliability: 2)
A0A396GYS0_MEDTR
457
0
52785
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2G9HXH1_9LAMI
166
0
18652
TrEMBL
other Location (Reliability: 2)
A0A072TL01_MEDTR
353
0
39919
TrEMBL
other Location (Reliability: 2)
A0A2P6RV84_ROSCH
301
0
34112
TrEMBL
other Location (Reliability: 4)
A0A396GUN0_MEDTR
355
0
40376
TrEMBL
other Location (Reliability: 2)
A0A072VFZ2_MEDTR
358
0
40386
TrEMBL
other Location (Reliability: 2)
A0A072UER0_MEDTR
353
0
40116
TrEMBL
other Location (Reliability: 5)
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Hagel, J.M.; Facchini, P.J.
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
Nat. Chem. Biol.
6
273-275
2010
Papaver somniferum
brenda
Farrow, S.C.; Facchini, P.J.
Dioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy
J. Biol. Chem.
288
28997-29012
2013
Papaver somniferum
brenda
Hashemi, S.; Naghavi, M.
Production and gene expression of morphinan alkaloids in hairy root culture of Papaver orientale L. using abiotic elicitors
Plant Cell
125
31-41
2016
Papaver orientale
-
brenda
Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Kalra, A.
Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids
Planta
243
1097-1114
2016
Papaver somniferum
brenda