Information on EC 1.14.11.24 - 2'-deoxymugineic-acid 2'-dioxygenase

for references in articles please use BRENDA:EC1.14.11.24
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The expected taxonomic range for this enzyme is: Hordeum vulgare

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EC NUMBER
COMMENTARY hide
1.14.11.24
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RECOMMENDED NAME
GeneOntology No.
2'-deoxymugineic-acid 2'-dioxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-deoxymugineic acid + 2-oxoglutarate + O2 = mugineic acid + succinate + CO2
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
hydroxylated mugineic acid phytosiderophore biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
Requires iron(II). It is also likely that this enzyme can catalyse the hydroxylation of 3-epihydroxy-2'-deoxymugineic acid to form 3-epihydroxymugineic acid.
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CAS REGISTRY NUMBER
COMMENTARY hide
133758-62-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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concomitant introduction of the Glycine max ferritin gene and Hordeum vulgare mugineic acid biosynthetic genes effectively increases the seed iron level without causing iron sensitivity under iron-limited conditions in Oryza sativa, overview
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-deoxymugineic acid + 2-oxoglutarate + O2
mugineic acid + succinate + CO2
show the reaction diagram
3-epihydroxy-2'-deoxymugineic acid + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
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?
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37700
x * 37700, calculation from nucleotide sequence
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 37700, calculation from nucleotide sequence
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
introduction of the Ids3 gene into Oryza sativa cultivar Nipponbare and Tsukinohikari which lack Ids3 homologues
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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introduction of Glycine max ferritin gene driven by two endosperm-specific promoters, along with Hordeum vulgare nicotianamine synthase gene HvNAS, two nicotianamine aminotransferase genes HvNAAT-A and -B, and mugineic acid synthase gene IDS3 to enhance mugineic acid production in Oryza sativa sp. japonica cv. Tsukinohikari plant seeds. Lines expressing both ferritin and mugineic acid biosynthetic genes show signs of iron-deficiency tolerance in calcareous soil, phenotypes, overview
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.11.24)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)