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Disease on EC 1.13.12.7 - firefly luciferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.
Adenocarcinoma
Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice.
Establishment of a cellular assay system for G protein-linked receptors: coupling of human NK2 and 5-HT2 receptors to phospholipase C activates a luciferase reporter gene.
Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice.
Adenocarcinoma of Lung
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models.
Adenoviridae Infections
Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene.
Alzheimer Disease
A new bioluminescence-based tool for modulating target proteins in live cells.
Asthma
Ability of polymorphonuclear leukocytes to generate active oxygen species in children with bronchial asthma. Use of chemiluminescence probes with a Cypridina luciferin analog and luminol.
Bacteriuria
Analysis of the disagreement between automated bioluminescence-based and culture methods for detecting significant bacteriuria, with proposals for standardizing evaluations of bacteriuria detection methods.
Clinical and biochemical applications of luciferases and luciferins.
Evaluation of an adenosine 5'-triphosphate assay as a screening method to detect significant bacteriuria.
Firefly luciferase ATP assay as a screening method for bacteriuria.
Screening of bacteria in urine using luciferin-luciferase assay of microbial ATP: a comparative study.
Brain Injuries
In vivo bioluminescence imaging of neurogenesis - the role of the blood brain barrier in an experimental model of Parkinson's disease.
Brain Neoplasms
A novel pre-clinical in vivo mouse model for malignant brain tumor growth and invasion.
A novel rat model for glioblastoma multiforme using a bioluminescent F98 cell line.
Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors.
Detection of Brain Tumors and Systemic Metastases Using NanoLuc and Fluc for Dual Reporter Imaging.
Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain.
Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging.
Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.
Pulsed-wave low-dose ultrasound hyperthermia selectively enhances nanodrug delivery and improves antitumor efficacy for brain metastasis of breast cancer.
Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging.
Systemic AAV9-IFN? gene delivery treats highly invasive glioblastoma.
Breast Neoplasms
A multimodality imaging model to track viable breast cancer cells from single arrest to metastasis in the mouse brain.
A Novel Cationic Microbubble Coated with Stearic Acid-Modified Polyethylenimine to Enhance DNA Loading and Gene Delivery by Ultrasound.
A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy.
Anti?inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF??B pathway.
Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy.
C19 steroids estrogenic activity in human breast cancer cell lines: importance of dehydroepiandrosterone sulfate at physiological plasma concentration.
Conversion of dehydroepiandrosterone sulfate at physiological plasma concentration into estrogens in MCF-7 cells.
Dehydroepiandrosterone sulfate estrogenic action at its physiological plasma concentration in human breast cancer cell lines.
Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumors.
Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes.
Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis.
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
Enhanced Anti-Tumor Efficacy through a Combination of Integrin ?v?6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.
Estrogenic/antiestrogenic activity of selected selective serotonin reuptake inhibitors.
In vitro modulation of estrogen receptor activity by norfluoxetine.
In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system.
In vivo monitoring of CD44+ cancer stem-like cells by ?-irradiation in breast cancer.
In Vivo Photoactivation Without "Light": Use of Cherenkov Radiation to Overcome the Penetration Limit of Light.
Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosis.
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Multimodal fluorescence- and bioluminescence imaging reveals transfection potential of intratracheally administered polyplexes for breast cancer lung metastases.
Novel isoprenoyl nanoassembled prodrug for Paclitaxel delivery.
Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing.
Prolonged treatment of breast cancer cells with antiestrogens increases the activating protein-1-mediated response: involvement of the estrogen receptor.
Pulsed-wave low-dose ultrasound hyperthermia selectively enhances nanodrug delivery and improves antitumor efficacy for brain metastasis of breast cancer.
Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation.
Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay.
Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer.
Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2.
The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs.
The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.
Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts.
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
Bronchitis
Towards Construction of Viral Vectors Based on Avian Coronavirus Infectious Bronchitis Virus for Gene Delivery and Vaccine Development.
Burkitt Lymphoma
Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood.
Carcinogenesis
The human splice variant ?16HER2 induces rapid tumor onset in a reporter transgenic mouse.
Carcinoma
A nonviral vector with transfection activity comparable with adenoviral transduction.
An immunocompetent murine model of metastatic mammary cancer accessible to bioluminescence imaging.
Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity.
Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions.
Effect of Sugar 2',4'-Modifications on Gene Silencing Activity of siRNA Duplexes.
Efficacy assessment of sustained intraperitoneal paclitaxel therapy in a murine model of ovarian cancer using bioluminescent imaging.
Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro.
Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors.
Human bone marrow mesenchymal stem cells functionalized by hybrid baculovirus-adeno-associated viral vectors for targeting hypopharyngeal carcinoma.
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients.
Interference of contaminated sediment extracts and environmental pollutants with retinoid signaling.
Investigation on the transcription factors of porcine 3?-hydroxysteroid dehydrogenase and 17?-hydroxysteroid dehydrogenase genes.
Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts.
Murine bioluminescent hepatic tumour model.
NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation.
Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer.
Synergistic effect of interstitial laser coagulation and doxorubicin in a murine tumor recurrence model of solitary colorectal liver metastasis.
Use of the ODD-Luciferase Transgene for the Non-Invasive Imaging of Spontaneous Tumors in Mice.
Visualization of effective tumor targeting by CD8+ natural killer T cells redirected with bispecific antibody F(ab')(2)HER2xCD3.
Carcinoma, Embryonal
Regulation of the rat oxytocin gene by estradiol.
Thyroid hormone regulates the oxytocin gene.
Vasopressin gene expression is stimulated by cyclic AMP in homologous and heterologous expression systems.
Carcinoma, Hepatocellular
A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.
Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma.
Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds.
Cloning and characterization of the promoter region of a gene encoding a 67-kDa glycoprotein.
Cloning the genomic sequence and identification of promoter regions of bovine pyruvate carboxylase.
Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer through optical molecular imaging.
Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.
Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter.
Dual-modality monitoring of tumor response to cyclophosphamide therapy in mice with bioluminescence imaging and small-animal positron emission tomography.
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
In Vitro Design and Characterization of the Nonviral Gene Delivery Vector Iopamidol, Protamine, Ethiodized Oil Reagent.
Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo.
Inhibition of internal ribosomal entry site-directed translation of HCV by recombinant IFN-alpha correlates with a reduced La protein.
Isolation and characterization of the human gp130 promoter. Regulation by STATS.
Molecular cloning and sequence analysis of the rat liver carnitine octanoyltransferase cDNA, its natural gene and the gene promoter.
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene.
Propionate induces the bovine cytosolic phosphoenolpyruvate carboxykinase promoter activity.
Regulation of human apolipoprotein A-I expression in Caco-2 and HepG2 cells by all-trans and 9-cis retinoic acids.
Relative potencies of PAHs and PCBs based on the response of human cells.
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.
Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins.
Usefulness of the MRP2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP1B1.
Carcinoma, Lewis Lung
Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors.
Murine bioluminescent hepatic tumour model.
Carcinoma, Non-Small-Cell Lung
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients.
Carcinoma, Renal Cell
Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity.
Effect of Sugar 2',4'-Modifications on Gene Silencing Activity of siRNA Duplexes.
Carcinoma, Squamous Cell
Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosis.
Cardiomegaly
Identification and visualization of stimulus-specific transcriptional activity in cardiac hypertrophy in mice.
Cardiovascular Diseases
A Synthetic Luciferin Improves In Vivo Bioluminescence Imaging of Gene Expression in Cardiovascular Brain Regions.
Central Nervous System Infections
Persistent infection of a gammaherpesvirus in the central nervous system.
Choriocarcinoma
Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling.
The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.
Classical Swine Fever
Generation of a recombinant classical swine fever virus stably expressing the firefly luciferase gene for quantitative antiviral assay.
Coinfection
Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway.
Colonic Neoplasms
Bioluminescent molecular imaging of endogenous and exogenous p53-mediated transcription in vitro and in vivo using an HCT116 human colon carcinoma xenograft model.
Development of a metastatic murine colon cancer model.
Visualization of the Biological Behavior of Tumor-Associated Macrophages in Living Mice with Colon Cancer Using Multimodal Optical Reporter Gene Imaging.
Colorectal Neoplasms
A cell-based screen for inhibitors of protein folding and degradation.
Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
COVID-19
An optimized and robust SARS-CoV-2 pseudovirus system for viral entry research.
Dehydration
Quantitative imaging of gene expression in individual bacterial cells by chemiluminescence.
Dengue
Towards Construction of Viral Vectors Based on Avian Coronavirus Infectious Bronchitis Virus for Gene Delivery and Vaccine Development.
Diabetes Mellitus
Improvement of an impaired chemiluminescence response to formyl-methionyl-leucyl-phenylalanine in neutrophils from patients with non insulin dependent diabetes mellitus by recombinant human granulocyte-colony stimulating factor.
Diabetes Mellitus, Type 1
Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase.
Diphtheria
Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing.
Distemper
Host range and receptor utilization of canine distemper virus analyzed by recombinant viruses: Involvement of heparin-like molecule in CDV infection.
Encephalitis, Viral
Visualizing production of interferon-? by astrocytes and microglia in the brain of La Crosse virus-infected mice.
Encephalomyelitis
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Feline Infectious Peritonitis
Coronaviruses as vectors: stability of foreign gene expression.
Fetal Death
Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector.
Fibrosarcoma
Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA.
Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells.
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models.
Resistance to heat radiosensitization and protein damage in thermotolerant and thermoresistant cells.
Glioblastoma
A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature.
Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity.
Detection of Brain Tumors and Systemic Metastases Using NanoLuc and Fluc for Dual Reporter Imaging.
Firefly Luciferase Inhibitor-Conjugated Peptide Quenches Bioluminescence: A Versatile Tool for Real Time Monitoring Cellular Uptake of Biomolecules.
Glioblastoma therapy with cytotoxic mesenchymal stromal cells optimized by bioluminescence imaging of tumor and therapeutic cell response.
In Vivo Follow-Up of Gene Inhibition in Solid Tumors Using Peptide-Based Nanoparticles for siRNA Delivery.
Multimodal molecular imaging system for pathway-specific reporter gene expression.
Therapeutic Effect of IL-4 Receptor-Targeting Pro-Apoptotic Peptide (AP1-ELP-KLAK) in Glioblastoma Tumor Model.
Glioma
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
A novel rat model for glioblastoma multiforme using a bioluminescent F98 cell line.
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging.
Development and Characterisation of a Novel NF-?B Reporter Cell Line for Investigation of Neuroinflammation.
Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression.
In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model.
In vivo tracking of neural progenitor cell migration to glioblastomas.
Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.
Multimodal imaging of neural progenitor cell fate in rodents.
Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect.
Synergistic inhibition of glioma cell proliferation by Withaferin A and tumor treating fields.
Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells.
Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Gliosarcoma
Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging.
The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro.
Hepatitis
Coronaviruses as vectors: stability of foreign gene expression.
Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells.
Fluorogenic RNA nanoparticles for monitoring RNA folding and degradation in real time in living cells.
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex.
Hepatitis A
Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells.
Hepatitis B
Development of ultra-high sensitivity bioluminescent enzyme immunoassay for hepatitis B virus surface antigen using firefly luciferase.
Practical application of bioluminescence enzyme immunoassay using enhancer for firefly luciferin-luciferase bioluminescence.
Use of SV40-based vectors to transduce foreign genes to normal human peripheral blood mononuclear cells.
Hepatitis C
A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
Activation of interferon-stimulated response element in huh-7 cells replicating hepatitis C virus subgenomic RNA.
Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic replicon.
Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication.
Hepatitis, Chronic
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
Hepatoblastoma
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription.
Herpes Simplex
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo.
An A/G-rich motif in the rat fibroblast growth factor-2 gene confers enhancer activity on a heterologous promoter in neonatal rat cardiac myocytes.
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors.
Coexpression of the partial androgen receptor enhances the efficacy of prostate-specific antigen promoter-driven suicide gene therapy for prostate cancer cells at low testosterone concentrations.
Controlling and monitoring stem cell safety in vivo in an experimental rodent model.
CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes.
Effect of the rabbit alphas1-casein gene distal enhancer on the expression of a reporter gene in vitro and in vivo.
Effects of Endogenous Proteins and microRNA Target Sequence in a Positive Feedback System.
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model.
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virion.
Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging.
Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models.
Imaging of embryonic stem cell migration in vivo.
Imaging of mesenchymal stem cell transplant by bioluminescence and PET.
Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.
Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system.
Long term non-invasive imaging of embryonic stem cells using reporter genes.
Luciferase assay to study the activity of a cloned promoter DNA fragment.
Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Molecular imaging of human embryonic stem cells.
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Multimodal imaging of neural progenitor cell fate in rodents.
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice.
Rational design of a triple reporter gene for multimodality molecular imaging.
Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging.
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
Spying on cancer: molecular imaging in vivo with genetically encoded reporters.
Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.
Transgenic reporter mouse for bioluminescence imaging of herpes simplex virus 1 infection in living mice.
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases.
Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Herpesviridae Infections
Video imaging of firefly luciferase activity to identify and monitor herpesvirus infection in cell culture.
HIV Infections
Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses.
Use of new T-cell-based cell lines expressing two luciferase reporters for accurately evaluating susceptibility to anti-human immunodeficiency virus type 1 drugs.
Huntington Disease
Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells.
Hypersensitivity
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.
Hyperthyroidism
Evaluation of highly sensitive thyrotropin assay for detecting thyroid diseases in neonatal screening: preliminary studies.
Hypothyroidism
Evaluation of highly sensitive thyrotropin assay for detecting thyroid diseases in neonatal screening: preliminary studies.
Infections
4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.
A quantitative assay for measuring of bovine immunodeficiency virus using a luciferase-based indicator cell line.
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.
An LASV GPC pseudotyped virus based reporter system enables evaluation of vaccines in mice under non-BSL-4 conditions.
An optimized and robust SARS-CoV-2 pseudovirus system for viral entry research.
Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging.
Bioluminescence imaging of vaccinia virus: effects of interferon on viral replication and spread.
Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection.
Effect of a Single Nucleotide Polymorphism in the LAMA1 Promoter Region on Transcriptional Activity: Implication for Pathological Myopia.
Efficient lentiviral vectors for short hairpin RNA delivery into human cells.
ENTRY SITES OF VENEZUELAN AND WESTERN EQUINE ENCEPHALITIS VIRUSES IN THE MOUSE CENTRAL NERVOUS SYSTEM FOLLOWING PERIPHERAL INFECTION.
Ex vivo infection of live tissue with oncolytic viruses.
Expression of human amyloid precursor proteins in cultured neuronal cells through the use of HSV-1 defective vectors.
Generation of stable L. major(+EGFP-LUC) and simultaneous comparison between EGFP and luciferase sensitivity.
High-throughput titration of luciferase-expressing recombinant viruses.
Human Adipose Tissue Stem Cells Promote the Growth of Acute Lymphoblastic Leukemia Cells in NOD/SCID Mice.
Imaging gene expression in live transgenic mice after providing luciferin in drinking water.
Improvement of an impaired chemiluminescence response to formyl-methionyl-leucyl-phenylalanine in neutrophils from patients with non insulin dependent diabetes mellitus by recombinant human granulocyte-colony stimulating factor.
In vivo bioluminescence imaging for prolonged survival of transplanted human neural stem cells using 3D biocompatible scaffold in corticectomized rat model.
Luciferase real-time bioluminescence imaging for the study of viral pathogenesis.
Measurement of Mouse Cytomegalovirus-Induced Interferon-? with Immortalized Luciferase Reporter Cells.
Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.
Monitoring recombinant baculovirus replication in Spodoptera litura (Lepidoptera: Noctuidae) larvae by using firefly luciferase gene as a reporter.
Murine alveolar macrophages limit replication of vaccinia virus.
Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.
Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene.
Red-Shifted Firefly Luciferase Optimized for Candida albicans In vivo Bioluminescence Imaging.
Simultaneous synthesis of enzymatically active luciferase and biologically active beta subunit of human chorionic gonadotropin in caterpillars infected with a recombinant baculovirus.
Successful biolistic transformation of mouse pancreatic islets while preserving cellular function.
Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells.
Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors.
Titration of cell-associated varicella-zoster virus with the MV9G reporter cell line for antiviral studies.
Transcriptional transactivation of parvovirus B19 promoters in nonpermissive human cells by adenovirus type 2.
Transgenic reporter mouse for bioluminescence imaging of herpes simplex virus 1 infection in living mice.
Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus.
Use of a novel cross-linking method to modify adenovirus tropism.
Influenza, Human
In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses.
Pseudotype Neutralization Assays: From Laboratory Bench to Data Analysis.
The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes.
The use of equine influenza pseudotypes for serological screening.
Virus-inducible reporter genes as a tool for detecting and quantifying influenza A virus replication.
Insulinoma
A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesis.
Kidney Neoplasms
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models.
Leukemia
Bioluminescence imaging of leukemia cell lines in vitro and in mouse xenografts: effects of monoclonal and polyclonal cell populations on intensity and kinetics of photon emission.
Factors affecting long-term stability of Moloney murine leukemia virus-based vectors.
Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles.
Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions.
Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions.
Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.
Use of Humanized RS-ATL8 Reporter System for Detection of Allergen-Specific IgE Sensitization in Human Food Allergy.
Leukemia, Erythroblastic, Acute
A new system that analyzes erythropoietin-mediated early signal transduction: transfection of the c-fos enhancer.promoter-luciferase gene into a murine erythroid cell line.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Comparison of cell-labeling methods with ¹²?I-FIAU and ??Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase.
Liver Diseases
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
Lung Diseases
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung.
Lung Neoplasms
Bioluminescence imaging correlates with tumor progression in an orthotopic mouse model of lung cancer.
Gene silencing activity of siRNA polyplexes based on biodegradable polymers.
Gene Silencing Activity of siRNA Polyplexes Based on Thiolated N,N,N-Trimethylated Chitosan.
Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library.
Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells.
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
Lymphoma
Human umbilical cord mesenchymal stem cells as vehicles of CD20-specific TRAIL fusion protein delivery: a double-target therapy against non-Hodgkin's lymphoma.
Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood.
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation.
Lymphoma, B-Cell
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation.
Malaria
An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle.
Transfection of the malaria parasite and expression of firefly luciferase.
Melanoma
Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.
Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice.
Efficient gene transfer into Xiphophorus muscle and melanoma by injection of supercoiled plasmid DNA.
Identification of a cis-acting element that enhances the pigment cell-specific expression of the human tyrosinase gene.
Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence.
In vivo electroporation-mediated transfer of interleukin-12 and interleukin-18 genes induces significant antitumor effects against melanoma in mice.
Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells.
Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis.
Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.
PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.
Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice.
Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors.
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
[Modulation of Luciferase Production in Melanoma Cells in vitro].
Metabolic Diseases
In vivo monitoring of pancreatic beta-cells in a transgenic mouse model.
Multiple Myeloma
A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect.
Multiple Sclerosis
[Construction and identification of luciferase reporter gene containing mouse T-bet promoter].
Muscular Dystrophies
Induced Pluripotent Stem Cells derived Muscle Progenitors Effectively Mitigate Muscular Dystrophy through Restoring the Dystrophin Distribution.
Mycoses
Visualizing fungal infections in living mice using bioluminescent pathogenic Candida albicans strains transformed with the firefly luciferase gene.
Myocardial Infarction
IGF-1C domain-modified hydrogel enhanced the efficacy of stem cells in the treatment of AMI.
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia.
Nasopharyngeal Carcinoma
Differential expression in human cells from the p6 promoter of human parvovirus B19 following plasmid transfection and recombinant adeno-associated virus 2 (AAV) infection: human megakaryocytic leukaemia cells are non-permissive for AAV infection.
Neoplasm Metastasis
An orthotopic, postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis.
Bioluminescent orthotopic model of pancreatic cancer progression.
Characterization of thyroid cancer cell lines in murine orthotopic and intracardiac metastasis models.
Combined noninvasive imaging and luminometric quantification of luciferase-labeled human prostate tumors and metastases.
Detection of Brain Tumors and Systemic Metastases Using NanoLuc and Fluc for Dual Reporter Imaging.
Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice.
Differential microRNA expression profiles in HCT116 colorectal cancer cell lines located in the lung and colon.
Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy.
Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta,17beta-diol.
Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis.
High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.
Human Embryonic Stem Cell-Derived Endothelial Cells as Cellular Delivery Vehicles for Treatment of Metastatic Breast Cancer.
Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo.
In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
Inhibition of transforming growth factor-?-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis.
Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells.
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models.
Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities.
Multimodal fluorescence- and bioluminescence imaging reveals transfection potential of intratracheally administered polyplexes for breast cancer lung metastases.
Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasis.
Multimodality imaging of TGF{beta} signaling in breast cancer metastases.
Novel isoprenoyl nanoassembled prodrug for Paclitaxel delivery.
Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells.
Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors.
Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer.
Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling.
TMTP1-modified Indocyanine Green-loaded Polymeric Micelles for Targeted Imaging of Cervical Cancer and Metastasis Sentinel Lymph Node in vivo.
[Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice].
Neoplasm Micrometastasis
The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis.
Neoplasms
2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation.
A gastrin transcript expressed in gastrointestinal cancer cells contains an internal ribosome entry site.
A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.
A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy.
A novel model of intracranial meningioma in mice using luciferase-expressing meningioma cells. Laboratory investigation.
A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases.
A tightly regulated and reversibly inducible siRNA expression system for conditional RNAi-mediated gene silencing in mammalian cells.
A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia.
Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells.
Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model.
Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma.
Artificial MicroRNAs as Novel Secreted Reporters for Cell Monitoring in Living Subjects.
Assessing the in vivo efficacy of doxorubicin loaded hyaluronan nanoparticles.
Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.
Bioluminescence imaging of a tumor-selective, thymidine kinase-defective vaccinia virus Guang9 strain after intratumoral or intraperitoneal administration in mice.
Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy.
Bioluminescent orthotopic model of pancreatic cancer progression.
Bioluminescent Turn-On Probe for Sensing Hypochlorite in Vitro and in Tumors.
CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma.
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Characterization of thyroid cancer cell lines in murine orthotopic and intracardiac metastasis models.
Combined E7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer.
Combined in vivo bioluminescence and fluorescence imaging for cancer gene therapy.
Combined noninvasive imaging and luminometric quantification of luciferase-labeled human prostate tumors and metastases.
Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.
Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs.
Comparison of optical and power Doppler ultrasound imaging for non-invasive evaluation of arsenic trioxide as a vascular disrupting agent in tumors.
Comparison of subcutaneous and intraperitoneal injection of D-luciferin for in vivo bioluminescence imaging.
Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer through optical molecular imaging.
Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model.
Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy.
Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer.
Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate.
Detection of Brain Tumors and Systemic Metastases Using NanoLuc and Fluc for Dual Reporter Imaging.
Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis.
Development of a metastatic murine colon cancer model.
Different effect of paclitaxel on primary tumor mass, tumor cell contents, and metastases for four experimental human prostate tumors expressing luciferase.
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
Dual-modality monitoring of tumor response to cyclophosphamide therapy in mice with bioluminescence imaging and small-animal positron emission tomography.
Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.
Effect of magnetic fields on tumor growth and viability.
Elevated mPer1 gene expression in tumor stroma imaged through bioluminescence.
Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer.
Enhanced Anti-Tumor Efficacy through a Combination of Integrin ?v?6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.
Enhanced transgene expression and effective in vivo antitumor immune responses initiated by dendritic progenitors transfected with a nonviral T7 vector expressing a model tumor antigen.
Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta,17beta-diol.
Evaluation of chemical chaperones based on the monitoring of Bip promoter activity and visualization of extracellular vesicles by real-time bioluminescence imaging.
Evaluation of Firefly Luciferase Bioluminescence Mediated Photodynamic Toxicity in Cancer Cells.
Evaluation of firefly luciferase bioluminescence mediated photodynamic toxicity in cancer cells.
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Extended-release PEG-luciferin allows for long-term imaging of firefly luciferase activity in vivo.
Formulation of photon diffusion from spherical bioluminescent sources in an infinite homogeneous medium.
Gaussia Luciferase for Bioluminescence Tumor Monitoring in Comparison with Firefly Luciferase.
Gene transfer-mediated intracellular photodynamic therapy.
Generation of Luciferase-expressing Tumor Cell Lines.
Generation of Tumor Cells Expressing Firefly Luciferase (fLuc) to Evaluate the Effectiveness of CAR in a Murine Model.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression.
Glucosamine-Linked Near-Infrared Fluorescent Probes for Imaging of Solid Tumor Xenografts.
High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.
How to Select Firefly Luciferin Analogues for In Vivo Imaging.
Human adipose tissue-derived mesenchymal stromal cells as vehicles for tumor bystander effect: a model based on bioluminescence imaging.
Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.
IFN-? mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity.
Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds.
Imaging chemokine receptor dimerization with firefly luciferase complementation.
Imaging gene expression in live transgenic mice after providing luciferin in drinking water.
Imaging neural stem cell fate in mouse model of glioma.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence.
Immune response to firefly luciferase as a naked DNA.
In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma.
In Vivo Bioluminescence Imaging of Murine Xenograft Cancer Models with a Red-shifted Thermostable Luciferase.
In Vivo Bioluminescence Imaging Validation of a Human Biopsy-derived Orthotopic Mouse Model of Glioblastoma Multiforme.
In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene.
In vivo bioluminescent imaging of mammary tumors using IVIS spectrum.
In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
In vivo monitoring of CD44+ cancer stem-like cells by ?-irradiation in breast cancer.
Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.
Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer.
Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells.
Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex.
Interrogating androgen receptor function in recurrent prostate cancer.
Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.
Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.
Intratumoral DNA electroporation induces anti-tumor immunity and tumor regression.
Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice.
Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging.
In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand.
Long-term ex vivo and in vivo monitoring of tumor progression by using dual luciferases.
Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo.
Luminescence applications for chemotherapeutic drug development.
Monitoring of tumour progression using bioluminescence imaging and computed tomography scanning in a nude mouse orthotopic model of human small cell lung cancer.
Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells.
Multimodal fluorescence- and bioluminescence imaging reveals transfection potential of intratracheally administered polyplexes for breast cancer lung metastases.
Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer.
Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development.
Murine tyrosinase expressed by a T7 vector in bone marrow-derived dendritic progenitors effectively prevents and eradicates melanoma tumors in mice.
Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation.
Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect.
Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy.
Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene.
Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
Noninvasive in vivo whole body luminescent analysis of luciferase labelled orthotopic prostate tumours.
Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein.
Novel isoprenoyl nanoassembled prodrug for Paclitaxel delivery.
Oncolytic herpes simplex virus counteracts the hypoxia-induced modulation of glioblastoma stem-like cells.
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer.
Opening Up the Optical Imaging Window Using Nano-Luciferin.
Optical imaging of transferrin targeted PEI/DNA complexes in living subjects.
Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals.
Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells.
PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.
Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung.
Persistence of High-Grade Cervical Dysplasia and Cervical Cancer Requires the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncogene.
Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and not influx, as the bigger hurdle in cancer drug therapy.
Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector.
Preclinical evaluation of ex vivo expanded/activated gammadelta T cells for immunotherapy of glioblastoma multiforme.
Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin.
Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer.
Prompt assessment of WST11-VTP outcome using luciferase transfected tumors enables second treatment and increase in overall therapeutic rate.
Proteasome inhibitors reduce luciferase and beta-galactosidase activity in tissue culture cells.
Quantitative and Functional Requirements for Bioluminescent Cancer Models.
Quantitative bioluminescence imaging of mouse tumor models.
Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts.
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
Rapid obtention of stable, bioluminescent tumor cell lines using a tCD2-luciferase chimeric construct.
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo.
Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy.
Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice.
Replacement of quaternary ammonium headgroups by tri-ornithine in cationic lipids for the improvement of gene delivery in vitro and in vivo.
S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells.
Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase.
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells.
Supplementation with selenium-enriched yeast attenuates brain metastatic growth.
Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane.
Synergistic effects of host B7-H4 deficiency and gemcitabine treatment on tumor regression and anti-tumor T cell immunity in a mouse model.
Systemic Delivery of an Oncolytic Adenovirus Expressing Soluble Transforming Growth Factor-? Receptor II-Fc Fusion Protein Can Inhibit Breast Cancer Bone Metastasis in a Mouse Model.
Targeted Delivery of siRNA-Generating DNA Nanocassettes Using Multifunctional Nanoparticles.
Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins.
Targeting CD38-Expressing Multiple Myeloma and Burkitt Lymphoma Cells In Vitro with Nanobody-Based Chimeric Antigen Receptors (Nb-CARs).
Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells.
Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2.
The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs.
The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging.
The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.
The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis.
The use of recombinant adeno-associated viral vectors for the transduction of epithelial tumor cells.
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice.
Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.
Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts.
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
Use of a novel cross-linking method to modify adenovirus tropism.
Use of reporter genes for optical measurements of neoplastic disease in vivo.
Using Bioluminescence Turn-On To Detect Cysteine in Vitro and in Vivo.
Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Validity of bioluminescence measurements for noninvasive in vivo imaging of tumor load in small animals.
Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells.
Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging.
Visualization of effective tumor targeting by CD8+ natural killer T cells redirected with bispecific antibody F(ab')(2)HER2xCD3.
Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
WISP1/CCN4: A Potential Target for Inhibiting Prostate Cancer Growth and Spread to Bone.
Neuroblastoma
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1? by inhibition of synthesis and not enhanced degradation.
In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma.
Reporter gene assays for algal-derived toxins.
Neuroma, Acoustic
Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice.
Osteolysis
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
Osteosarcoma
A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family.
Advantages of bioluminescence imaging to follow siRNA or chemotherapeutic treatments in osteosarcoma preclinical models.
Ovarian Neoplasms
Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
Role of M2-like macrophages in the progression of ovarian cancer.
Pancreatic Neoplasms
Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis.
Gemcitabine upregulates ABCG2/BCRP and modulates the intracellular pharmacokinetic profiles of bioluminescence in pancreatic cancer cells.
Parasitemia
Generation of stable L. major(+EGFP-LUC) and simultaneous comparison between EGFP and luciferase sensitivity.
Paratuberculosis
Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis.
Parkinson Disease
alpha-Synuclein enhances bioluminescent activity of firefly luciferase by facilitating luciferin localization.
Peritonitis
Coronaviruses as vectors: stability of foreign gene expression.
Pheochromocytoma
Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites.
Pneumonia
Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene.
Poxviridae Infections
Murine alveolar macrophages limit replication of vaccinia virus.
Prolactinoma
[Melatonin inhibits the proliferation of pituitary prolactin-secreting tumor by suppressing the enhancer elements mutation of PRL gene in the rat]
Prostatic Neoplasms
Analysis of androgen receptor activity by reporter gene assays.
CXCR4 inhibition enhances radiosensitivity, while inducing cancer cell mobilization in a prostate cancer mouse model.
H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis.
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer.
Non-invasive imaging of firefly luciferase reporter gene expression using bioluminescence imaging in human prostate cancer models.
Poly(aminoether)-Gold Nanorod Assemblies for Plasmid shRNA-induced Gene Silencing.
Synergistic effect of ultrasound and PEI on DNA transfection in vitro.
Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer.
The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.
[Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice].
Pseudorabies
Firefly luciferase as a marker for herpesvirus (pseudorabies virus) replication in vitro and in vivo.
Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds.
Puberty, Precocious
A novel mutation of estrogen receptor gene detected in girls with precocious puberty.
Rabies
A recombinant rabies virus expressing luciferase.
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Novel, rapid assay for measuring entry of diverse enveloped viruses, including HIV and rabies.
Reperfusion Injury
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model.
Retinoblastoma
Rod photoreceptor-specific gene expression in human retinoblastoma cells.
Sarcoma, Avian
Avian retroviral expression of luciferase.
Behavior of genes directly injected into the rat heart in vivo.
Effect of intercistronic length on internal ribosome entry site (IRES) efficiency in bicistronic mRNA.
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer.
Gene transfer into specific vascular cells.
In ovo transfection of chicken embryos using cationic liposomes.
Prior arterial injury enhances luciferase expression following in vivo gene transfer.
The efficiency of different IRESs (internal ribosomes entry site) in monocistronic mRNAS.
Scoliosis
Prolonged down regulation of specific gene expression in nucleus pulposus cell mediated by RNA interference in vitro.
Sepsis
Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1? transgenic mice subjected to the lipopolysaccharide-induced sepsis.
Streptococcus pneumoniae elaborates persistent and prolonged competent state during pneumonia-derived sepsis.
Severe Combined Immunodeficiency
Interrogating androgen receptor function in recurrent prostate cancer.
Noninvasive assessment of tumor cell proliferation in animal models.
Nuclear expression of S100A4 calcium binding protein increases cholangiocarcinoma invasiveness and metastasization.
Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling.
Smallpox
Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox.
Squamous Cell Carcinoma of Head and Neck
A nonviral vector with transfection activity comparable with adenoviral transduction.
Stomach Neoplasms
Development of a cell-based pathway modulator screening system to screen the targeted cancer therapeutic candidates.
Identification of the targeted therapeutic potential of doxycycline for a subset of gastric cancer patients.
Non-invasive visualisation of the development of peritoneal carcinomatosis and tumour regression after 213Bi-radioimmunotherapy using bioluminescence imaging.
Noninvasive visualization of microRNA-16 in the chemoresistance of gastric cancer using a dual reporter gene imaging system.
Stroke
In vivo bioluminescence imaging of vascular remodeling after stroke.
Tauopathies
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Teratoma
Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma.
Thyroid Cancer, Papillary
Characterization of thyroid cancer cell lines in murine orthotopic and intracardiac metastasis models.
Thyroid Neoplasms
Characterization of thyroid cancer cell lines in murine orthotopic and intracardiac metastasis models.
Triple Negative Breast Neoplasms
Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging.
Multimodal fluorescence- and bioluminescence imaging reveals transfection potential of intratracheally administered polyplexes for breast cancer lung metastases.
Tuberculosis
A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis.
A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase.
Antibiotic-dependent correlation between drug-induced killing and loss of luminescence in Streptococcus gordonii expressing luciferase.
Construction and evaluation of luciferase reporter phages for the detection of active and non-replicating tubercle bacilli.
Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.
Reporter gene technology to assess activity of antimycobacterial agents in macrophages.
Urinary Bladder Neoplasms
A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging.
Cloning and analysis of human UroplakinII promoter and its application for gene therapy in bladder cancer.
Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin.
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer.
Uterine Cervical Neoplasms
Combined E7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer.
TMTP1-modified Indocyanine Green-loaded Polymeric Micelles for Targeted Imaging of Cervical Cancer and Metastasis Sentinel Lymph Node in vivo.
Vaccinia
A modified HIV challenge assay in mice by using luciferase-expressing vaccinia virus.
A mouse model based on replication-competent Tiantan vaccinia expressing luciferase/HIV-1 Gag fusion protein for the evaluation of protective efficacy of HIV vaccine.
Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant.
Bioluminescence imaging of vaccinia virus: effects of interferon on viral replication and spread.
Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox.
CCD imaging of luciferase gene expression in single mammalian cells.
Comparison of the replication characteristics of vaccinia virus strains Guang 9 and Tian Tan in vivo and in vitro.
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Ex vivo infection of live tissue with oncolytic viruses.
Expression of the firefly luciferase gene in vaccinia virus: a highly sensitive gene marker to follow virus dissemination in tissues of infected animals.
Murine alveolar macrophages limit replication of vaccinia virus.
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Screening and evaluation of potential inhibitors against vaccinia virus from 767 approved drugs.
TLR3 increases disease morbidity and mortality from vaccinia infection.
Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases.
Vaccinia virus entry into cells via a low-pH-dependent endosomal pathway.
[Analysis of reporter gene expression at different segments of the vaccinia virus genome]
Vesicular Stomatitis
A vesicular stomatitis virus replicon-based bioassay for the rapid and sensitive determination of multi-species type I interferon.
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G.
Virus Diseases
A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study.
Bioluminescence imaging of vaccinia virus: effects of interferon on viral replication and spread.
Circadian regulation of a viral gene promoter in live transgenic mice expressing firefly luciferase.
Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.
Oncolytic herpes simplex virus counteracts the hypoxia-induced modulation of glioblastoma stem-like cells.
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity.
Yellow Fever
Construction of yellow fever virus subgenomic replicons by yeast-based homologous recombination cloning technique.