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Information on EC 1.13.12.21 - tetracenomycin-F1 monooxygenase for references in articles please use BRENDA:EC1.13.12.21
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IUBMB Comments The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
The enzyme appears in viruses and cellular organisms
Synonyms
TcmF1 monooxygenase, TmcH,
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tetracenomycin F1 + O2 = tetracenomycin D3 + H2O
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tetracenomycin-F1:oxygen C5-monooxygenase
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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the enzyme is involved in the biosynthesis of tetracenomycin C
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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i.e. 3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-2-naphthacenecarboxylic acid
i.e. 3,8,10,12-tetrahydroxy-1-methyl-11-oxo-6,11-dihydro-2-tetracenecarboxylate, i.e. 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-11-oxo-2-naphthacenecarboxylic acid
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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the enzyme is involved in the biosynthesis of tetracenomycin C
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additional information
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does not possess a prosthetic group such as flavin or heme
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additional information
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does not use a metal ion
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CuCl2
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31% loss of activity
N-ethylmaleimide
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0.025 mM, complete inhibition
p-chloromercuribenzoate
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0.025 mM, complete inhibition
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0.00747
tetracenomycin F1
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pH 7.5, 30°C
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7 - 8
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pH 7.0: about 40% of maximal activity, pH 8.0: about 85% of maximal activity
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brenda
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physiological function
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the enzyme is involved in the biosynthesis of tetracenomycin C
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TCMH_STRGA
112
0
12683
Swiss-Prot
A0A518B8A8_9BACT
132
0
14943
TrEMBL
A0A120FZ10_PSEFL
121
0
13700
TrEMBL
A0A395L520_9RHIZ
101
0
11032
TrEMBL
A0A238KEM9_9RHOB
106
0
12155
TrEMBL
A0A5E8A5B6_9RHOB
106
0
11976
TrEMBL
A0A2Z5K340_9ACTN
106
0
11984
TrEMBL
A0A0L6CU44_9RHOB
106
0
12159
TrEMBL
A0A1X6YRR0_9RHOB
106
0
12071
TrEMBL
A0A2R8BLR6_9RHOB
105
0
12120
TrEMBL
A0A1X6ZE17_9RHOB
108
0
12271
TrEMBL
A0A447IQK5_9RHOB
107
0
12549
TrEMBL
A0A2P7ZYN7_9ACTN
113
0
12129
TrEMBL
A0A132BQC7_9RHOB
106
0
12132
TrEMBL
A0A2R8BAW6_9RHOB
122
0
13559
TrEMBL
A0A2P4UGT9_9ACTN
108
0
12154
TrEMBL
A0A2P4UEP4_9ACTN
109
0
12391
TrEMBL
A0A3N6FHR5_9ACTN
226
0
25925
TrEMBL
A0A3N6E235_9ACTN
117
0
13222
TrEMBL
A0A109LDT4_PSEFL
121
0
13765
TrEMBL
A0A5M9I7E6_PSEPA
121
0
13775
TrEMBL
A0A238K7M2_9RHOB
105
0
11933
TrEMBL
A0A5B1CF02_9PLAN
110
0
12091
TrEMBL
A0A1X6Z638_9RHOB
122
0
13590
TrEMBL
A0A5M9J0L5_9PSED
121
0
13825
TrEMBL
A0A178X5L1_9PSEU
106
0
11443
TrEMBL
A0A1X6ZAF0_9RHOB
106
0
12387
TrEMBL
A0A1V0RKD3_9RHOB
106
0
11975
TrEMBL
A0A557SRG5_9ARCH
104
0
11924
TrEMBL
A0A1X6YAA2_9RHOB
106
0
12254
TrEMBL
A0A238JLL3_9RHOB
106
0
12052
TrEMBL
A0A238KQS8_9RHOB
105
0
11945
TrEMBL
A0A1Y5RG75_9RHOB
106
0
12343
TrEMBL
A0A2S6X0I7_9ACTN
235
0
26220
TrEMBL
A0A222E2B3_9RHOB
105
0
11942
TrEMBL
A0A238J889_9RHOB
105
0
11868
TrEMBL
A0A2R8C6D4_9RHOB
106
0
12145
TrEMBL
A0A0L0JDV8_9ACTN
229
0
26176
TrEMBL
A0A0N0D8L5_9RHOB
106
0
12184
TrEMBL
A0A2R8AQ83_9RHOB
105
0
11918
TrEMBL
A0A1J5RQD5_9ZZZZ
106
0
12233
TrEMBL
A0A1X7A3M8_9RHOB
105
0
12249
TrEMBL
A0A2Z5JXF6_9ACTN
233
0
26230
TrEMBL
A0A2N7RK02_9PSED
121
0
13670
TrEMBL
A0A1Y5TM68_9RHOB
106
0
12067
TrEMBL
A0A484IAT8_9ARCH
64
0
7455
TrEMBL
A0A2R8AMF1_9RHOB
106
0
12241
TrEMBL
A0A2P7ZJ50_9ACTN
235
0
26389
TrEMBL
A0A0S4HZZ0_9PSED
121
0
13695
TrEMBL
A0A1Y5T356_9RHOB
106
0
12138
TrEMBL
A0A2W1JIF0_9CYAN
233
0
25841
TrEMBL
A0A1X7BLB1_9RHOB
106
0
12213
TrEMBL
A0A238J5G5_9RHOB
105
0
11811
TrEMBL
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12500
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3 * 12500, SDS-PAGE
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trimer
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3 * 12500, SDS-PAGE
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Shen, B.; Hutchinson, C.R.
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens
Biochemistry
32
6656-6663
1993
Streptomyces glaucescens
brenda
Summers, R.G.; Wendt-Pienkowski, E.; Motamedi, H.; Hutchinson, C.R.
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase
J. Bacteriol.
175
7571-7580
1993
Streptomyces glaucescens
brenda
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