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IUBMB Comments The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens .
Synonyms
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tetracenomycin F1 + O2 = tetracenomycin D3 + H2O
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MetaCyc
elloramycin biosynthesis, tetracenomycin C biosynthesis
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tetracenomycin-F1:oxygen C5-monooxygenase
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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Substrates: the enzyme is involved in the biosynthesis of tetracenomycin C
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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Substrates: i.e. 3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-2-naphthacenecarboxylic acid
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tetracenomycin F1 + O2
tetracenomycin D3 + H2O
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Substrates: the enzyme is involved in the biosynthesis of tetracenomycin C
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additional information
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does not possess a prosthetic group such as flavin or heme
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additional information
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does not use a metal ion
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CuCl2
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31% loss of activity
N-ethylmaleimide
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0.025 mM, complete inhibition
p-chloromercuribenzoate
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0.025 mM, complete inhibition
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0.00747
tetracenomycin F1
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pH 7.5, 30°C
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7 - 8
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pH 7.0: about 40% of maximal activity, pH 8.0: about 85% of maximal activity
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brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
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the enzyme is involved in the biosynthesis of tetracenomycin C
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TCMH_STRGA
112
0
12683
Swiss-Prot
other Location (Reliability: 2 )
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12500
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3 * 12500, SDS-PAGE
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trimer
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3 * 12500, SDS-PAGE
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Shen, B.; Hutchinson, C.R.
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens
Biochemistry
32
6656-6663
1993
Streptomyces glaucescens
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Summers, R.G.; Wendt-Pienkowski, E.; Motamedi, H.; Hutchinson, C.R.
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase
J. Bacteriol.
175
7571-7580
1993
Streptomyces glaucescens
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