Information on EC - fatty acid alpha-dioxygenase

for references in articles please use BRENDA:EC1.13.11.92
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IUBMB Comments
Contains heme. This plant enzyme catalyses the (2R)-hydroperoxidation of fatty acids. It differs from lipoxygenases and cyclooxygenases in that the oxygen addition does not target an unsaturated region in the fatty acid. In vitro the product undergoes spontaneous decarboxylation, resulting in formation of a chain-shortened aldehyde. In vivo the product may be reduced to a (2R)-2-hydroxyfatty acid. The enzyme, which is involved in responses to different abiotic and biotic stresses, has a wide substrate range that includes both saturated and unsaturated fatty acids.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
a (2R)-2-hydroperoxyfatty acid
alpha-dioxygenase, alpha-DOX1, AXX17_At3g00510, cce_4307, DOX1, fatty acid alpha-oxidase, PADOX-1, Piox, more
a fatty acid + O2 = a (2R)-2-hydroperoxyfatty acid
show the reaction diagram
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