Information on EC 1.13.11.83 - 4-hydroxy-3-prenylphenylpyruvate oxygenase

for references in articles please use BRENDA:EC1.13.11.83

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EC Tree 1 Oxidoreductases 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) 1.13.11 With incorporation of two atoms of oxygen 1.13.11.83 4-hydroxy-3-prenylphenylpyruvate oxygenase

IUBMB Comments

Requires non-heme-iron(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase.

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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3-dimethylallyl-4-hydroxyphenylpyruvate

3-dimethylallyl-4-hydroxymandelate

CO2

Synonyms
CloR, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

CloR

3 entries

CloR

Streptomyces roseochromogenus

Q8GHB1

742826

CloR

Streptomyces roseochromogenus DS 12976

Q8GHB1

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2

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PATHWAY SOURCE

PATHWAYS

KEGG

Biosynthesis of secondary metabolites, Novobiocin biosynthesis

MetaCyc

4-hydroxy-3-prenylbenzoate biosynthesis

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SYSTEMATIC NAME

IUBMB Comments

3-dimethylallyl-4-hydroxyphenylpyruvate:oxygen 1,2-oxidoreductase (3-dimethylallyl-4-hydroxymandelate forming)

Requires non-heme-iron(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

2 entries

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

Streptomyces roseochromogenus

Q8GHB1

742826

Substrates: -
Products: -

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

Streptomyces roseochromogenus DS 12976

Q8GHB1

742826

Substrates: -
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

2 entries

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

Streptomyces roseochromogenus

Q8GHB1

742826

Substrates: -
Products: -

3-dimethylallyl-4-hydroxyphenylpyruvate + O2

3-dimethylallyl-4-hydroxymandelate + CO2

Streptomyces roseochromogenus DS 12976

Q8GHB1

742826

Substrates: -
Products: -

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Fe2+

Streptomyces roseochromogenus

Q8GHB1

a non-heme iron enzyme, Fe2+ is required for enzyme activity. Replacement of Fe2+ with other monovalent or divalent metal ions (1 mM Cu+, Zn2+, Mg2+, or Mn2+) results in almost complete (95-98%) loss of enzymatic activity

742826

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Streptomyces roseochromogenus

Q8GHB1

the enzyme is not stimulated by addition of 2-oxoglutarate

742826

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Streptomyces roseochromogenus

742826

Q8GHB1

UniProt

brenda

Streptomyces roseochromogenus DS 12976

742826

Q8GHB1

UniProt

brenda

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Highest Expressing Human Cell Lines

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Cell Line Links

Gene Links

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q8GHB1 pBLAST

CLOR_STRRC

Streptomyces roseochromogenus subsp. oscitans

277

30496

Swiss-Prot