Reference on EC 1.13.11.5 - homogentisate 1,2-dioxygenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nozaki, M.
Nonheme iron dioxygenase
Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York
135-165
1974
Bos taurus, Pseudomonas fluorescens
-
Adachi, K.; Iwayama, Y.; Tanioka, H.; Takeda, Y.
Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens
Biochim. Biophys. Acta
118
88-97
1966
Pseudomonas fluorescens
Ravdin, R.G.; Crandall, D.I.
The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid
J. Biol. Chem.
189
137-149
1951
Rattus norvegicus
Knox, W.E.; Edwards, S.W.
Homogentisate oxidase of liver
J. Biol. Chem.
216
479-487
1955
Rattus norvegicus
Crandall, D.I.; Halikis, D.N.
Homogentisic acid oxidase. I. Distribution in animal tissues and relation to tyrosine metabolism in rat kidney
J. Biol. Chem.
208
629-638
1954
Cavia porcellus, Oryctolagus cuniculus, Pigeon, Rattus norvegicus
Durand, R.; Zenk, M.H.
Enzymes of the homogentisate ring-cleavage pathway in cell suspension cultures of higher plants
FEBS Lett.
39
218-220
1974
Agave toumeyana, Agrostemma githago, Coleus scutellarioides, Daucus carota, Drosophyllum lusitanicum, Glycine max, Melilotus albus, Nicotiana sylvestris, Phaseolus vulgaris, Pimpinella anisum, Ruta graveolens
Sugumaran, M.; Vaidyanathan, C.S.
Affinity chromatography of homogentisate-1,2-dioxygenase from Aspergillus niger
FEMS Microbiol. Lett.
4
343-347
1978
Aspergillus niger, Aspergillus niger UBC 814
-
Granadino, B.; Beltran-Valero de Bernabe, D.; Fernandez-Canon, J.M.; Penalva, M.A.; Rodriguez de Cordoba, S.
The human homogentisate 1,2-dioxygenase (HGO) gene
Genomics
43
115-122
1997
Homo sapiens (Q93099), Homo sapiens
Schmidt, S.R.; Gehrig, A.; Koehler, M.R.; Schmid, M.; Muller, C.R.; Kress, W.
Cloning of the homogentisate 1,2-dioxygenase gene, the key enzyme of alkaptonuria in mouse
Mamm. Genome
8
168-171
1997
Mus musculus
Fernandez-Canon, J.M.; Penalva, M.A.
Spectrophotometric determination of homogentisate using Aspergillus nidulans homogentisate dioxygenase
Anal. Biochem.
245
218-221
1997
Aspergillus nidulans
Hudecova, S.; Strakova, Z.; Krizanova, O.
Purification of the homogentisic acid oxidase from mammalian liver
Int. J. Biochem. Cell Biol.
27
1357-1363
1995
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Mus musculus
Fernandez-Canon, J.M.; Penalva, M.A.
Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues
J. Biol. Chem.
270
21199-21205
1995
Aspergillus nidulans (Q00667), Aspergillus nidulans, Aspergillus nidulans BiA1 (Q00667)
Titus, G.P.; Mueller, H.A.; Burgner, J.; Rodriguez de Cordoba, S.; Penalva, M.A.; Timm, D.E.
Crystal structure of human homogentisate dioxygenase
Nat. Struct. Biol.
7
542-546
2000
Bos taurus, Homo sapiens, Mus musculus
Schmidt, S.R.; Muller, C.R.; Kress, W.
Murine liver homogentisate 1,2-dioxygenase. Purification to homogeneity and novel biochemical properties
Eur. J. Biochem.
228
425-430
1995
Mus musculus
Gunsch, C.K.; Cheng, Q.; Kinney, K.A.; Szaniszlo, P.J.; Whitman, C.P.
Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications
Appl. Microbiol. Biotechnol.
68
405-411
2005
Exophiala lecanii-corni (Q6JDV6), Exophiala lecanii-corni
Veldhuizen, E.J.; Vaillancourt, F.H.; Whiting, C.J.; Hsiao, M.M.; Gingras, G.; Xiao, Y.; Tanguay, R.M.; Boukouvalas, J.; Eltis, L.D.
Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase
Biochem. J.
386
305-314
2005
Homo sapiens
Dixon, D.P.; Edwards, R.
Enzymes of tyrosine catabolism in Arabidopsis thaliana
Plant Sci.
171
360-366
2006
Arabidopsis thaliana (Q9ZRA2), Arabidopsis thaliana
Shimizu, M.; Yuda, N.; Nakamura, T.; Tanaka, H.; Wariishi, H.
Metabolic regulation at the tricarboxylic acid and glyoxylate cycles of the lignin-degrading basidiomycete Phanerochaete chrysosporium against exogenous addition of vanillin
Proteomics
5
3919-3931
2005
Phanerodontia chrysosporium
Borowski, T.; Georgiev, V.; Siegbahn, P.E.
Catalytic reaction mechanism of homogentisate dioxygenase: a hybrid DFT study
J. Am. Chem. Soc.
127
17303-17314
2005
Homo sapiens (Q93099), Homo sapiens
Kim, Y.H.; Cho, K.; Yun, S.H.; Kim, J.Y.; Kwon, K.H.; Yoo, J.S.; Kim, S.I.
Analysis of aromatic catabolic pathways in Pseudomonas putida KT 2440 using a combined proteomic approach: 2-DE/MS and cleavable isotope-coded affinity tag analysis
Proteomics
6
1301-1318
2006
Pseudomonas putida, Pseudomonas putida KT 2440
Kang, B.R.; Han, S.H.; Cho, S.M.; Anderson, A.J.; Kim, I.S.; Park, S.K.; Kim, Y.C.
Characterization of a homogentisate dioxygenase mutant in Pseudomonas chlororaphis O6
Curr. Microbiol.
56
145-149
2008
Pseudomonas chlororaphis, Pseudomonas chlororaphis O6
Yoon, S.S.; Karabulut, A.C.; Lipscomb, J.D.; Hennigan, R.F.; Lymar, S.V.; Groce, S.L.; Herr, A.B.; Howell, M.L.; Kiley, P.J.; Schurr, M.J.; Gaston, B.; Choi, K.H.; Schweizer, H.P.; Hassett, D.J.
Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration
EMBO J.
26
3662-3672
2007
Pseudomonas aeruginosa
Zhang, Y.; Wang, L.; Zhang, S.; Yang, H.; Tan, H.
hmgA, transcriptionally activated by HpdA, influences the biosynthesis of actinorhodin in Streptomyces coelicolor
FEMS Microbiol. Lett.
280
219-225
2008
Streptomyces coelicolor
Grasko, J.M.; Hooper, A.J.; Brown, J.W.; McKnight, C.J.; Burnett, J.R.
A novel missense HGD gene mutation, K57N, in a patient with alkaptonuria
Clin. Chim. Acta
403
254-256
2009
Homo sapiens (Q93099)
Munne-Bosch, S.; Falara, V.; Pateraki, I.; Lopez-Carbonell, M.; Cela, J.; Kanellis, A.K.
Physiological and molecular responses of the isoprenoid biosynthetic pathway in a drought-resistant Mediterranean shrub, Cistus creticus exposed to water deficit
J. Plant Physiol.
166
136-145
2009
Cistus creticus
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Tinti, L.; Spreafico, A.; Braconi, D.; Millucci, L.; Bernardini, G.; Chellini, F.; Cavallo, G.; Selvi, E.; Galeazzi, M.; Marcolongo, R.; Gallagher, J.A.; Santucci, A.
Evaluation of antioxidant drugs for the treatment of ochronotic alkaptonuria in an in vitro human cell model
J. Cell. Physiol.
225
84-91
2010
Homo sapiens
Toth, K.; Kiss-Laaszlo, Z.; Lenart, E.; Juhasz, K.; Takacs, K.; Bender, T.; Szabo, J.
Familiar ochronotic arthropathy-caused by a gene mutation traced three hundred years
Joint Bone Spine
77
355-357
2010
Homo sapiens
Zhou, G.L.; Cao, Y.; Li, M.; Zhang, L.C.; Yu, Y.S.; Jin, H.G.
Meat quality and carcass traits in relation to HGD-BstXI and HGD-HaeIII PCR-RFLP polymorphism in Chinese red cattle
Meat Sci.
85
270-273
2010
Bos taurus (B8YB76), Bos taurus Chinese red cattle (B8YB76)
Effelsberg, N.; Huegle, T.; Walker, U.
A metabolic cause of spinal deformity
Metab. Clin. Exp.
59
140-143
2010
Homo sapiens
Zhou, G.; Dudgeon, C.; Li, M.; Cao, Y.; Zhang, L.; Jin, H.
Molecular cloning of the HGD gene and association of SNPs with meat quality traits in Chinese red cattle
Mol. Biol. Rep.
37
603-611
2010
Bos taurus (B8YB76)
Laschi, M.; Tinti, L.; Braconi, D.; Millucci, L.; Ghezzi, L.; Amato, L.; Selvi, E.; Spreafico, A.; Bernardini, G.; Santucci, A.
Homogentisate 1,2 dioxygenase is expressed in human osteoarticular cells: implications in alkaptonuria
J. Cell. Physiol.
227
3254-3257
2012
Homo sapiens (Q93099), Homo sapiens
Mendez, V.; Agullo, L.; Gonzalez, M.; Seeger, M.
The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400
PLoS ONE
6
e17583
2011
Paraburkholderia xenovorans
Jeoung, J.H.; Bommer, M.; Lin, T.Y.; Dobbek, H.
Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase
Proc. Natl. Acad. Sci. USA
110
12625-12630
2013
Pseudomonas putida (Q88E47), Pseudomonas putida KT 2240 (Q88E47)
Al-sbou, M.
Novel mutations in the homogentisate 1,2 dioxygenase gene identified in Jordanian patients with alkaptonuria
Rheumatol. Int.
32
1741-1746
2012
Homo sapiens (Q93099), Homo sapiens
Bernini, A.; Galderisi, S.; Spiga, O.; Bernardini, G.; Niccolai, N.; Manetti, F.; Santucci, A.
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease alkaptonuria
Comput. Biol. Chem.
70
133-141
2017
Homo sapiens (Q93099)
Mori, T.; Koyama, G.; Kawagishi, H.; Hirai, H.
Effects of homologous expression of 1,4-benzoquinone reductase and homogentisate 1,2-dioxygenase genes on wood decay in hyper-lignin-degrading fungus Phanerochaete sordida YK-624
Curr. Microbiol.
73
512-518
2016
Phanerochaete sordida, Phanerochaete sordida YK-624
Gonyar, L.A.; Fankhauser, S.C.; Goldberg, J.B.
Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates
Environ. Microbiol. Rep.
7
180-187
2015
Burkholderia cepacia, Burkholderia cepacia K56-2
Bernardini, G.; Laschi, M.; Geminiani, M.; Braconi, D.; Vannuccini, E.; Lupetti, P.; Manetti, F.; Millucci, L.; Santucci, A.
Homogentisate 1,2 dioxygenase is expressed in brain implications in alkaptonuria
J. Inherit. Metab. Dis.
38
807-814
2015
Homo sapiens, Mus musculus
Zolfaghari, N.
Molecular docking analysis of nitisinone with homogentisate 1,2 dioxygenase
Bioinformation
13
136-139
2017
Homo sapiens (Q93099)
Bernini, A.; Galderisi, S.; Spiga, O.; Amarabom, C.O.; Santucci, A.
Transient pockets as mediators of gas molecules routes inside proteins The case study of dioxygen pathway in homogentisate 1,2-dioxygenase and its implication in Alkaptonuria development
Comput. Biol. Chem.
88
107356
2020
Homo sapiens (Q93099)
Yang, W.; Ruan, L.; Tao, J.; Peng, D.; Zheng, J.; Sun, M.
Single amino acid substitution in homogentisate dioxygenase affects melanin production in Bacillus thuringiensis
Front. Microbiol.
9
2242
2018
Bacillus thuringiensis (ADH05034.1), Bacillus thuringiensis, Bacillus thuringiensis BMB171 (ADH05034.1)
Hughes, J.H.; Liu, K.; Plagge, A.; Wilson, P.J.M.; Sutherland, H.; Norman, B.P.; Hughes, A.T.; Keenan, C.M.; Milan, A.M.; Sakai, T.; Ranganath, L.R.; Gallagher, J.A.; Bou-Gharios, G.
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hum. Mol. Genet.
28
3928-3939
2019
Homo sapiens (Q93099)
Sen Gupta, P.S.; Islam, R.N.U.; Banerjee, S.; Nayek, A.; Rana, M.K.; Bandyopadhyay, A.K.
Screening and molecular characterization of lethal mutations of human homogentisate 1,2 dioxigenase
J. Biomol. Struct. Dyn.
39
1661-1671
2021
Homo sapiens (Q93099)
Wilson, P.J.M.; Ranganath, L.R.; Bou-Gharios, G.; Gallagher, J.A.; Hughes, J.H.
Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation
JIMD Rep.
58
52-60
2021
Mus musculus (O09173)
html completed
