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Information on EC 1.13.11.39 - biphenyl-2,3-diol 1,2-dioxygenase

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IUBMB Comments
Contains Fe2+ or Mn2+ . This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyses the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56, cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase.The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently . The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol . The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2-dihydroxydibenzofuran and 1,2-dihydroxynaphthalene . The enzyme is strongly inhibited by the substrate .Not identical with EC 1.13.11.2 catechol 2,3-dioxygenase.
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The enzyme appears in viruses and cellular organisms
Synonyms
2,3-dihydroxybiphenyl 1,2-dioxygenase, 2,3-dihydroxybiphenyl dioxygenase, bphc2, bphc1, bphc3, 2,3-dihydroxybiphenyl-1,2-dioxygenase, 2,3-dihydroxybiphenyl 1,2-dioxygenases, 2,3-dbpd, bphc_la-4, 2,3-dhbp dioxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
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also acts on 3-isopropylcatechol, forming 7-methyl-2-hydroxy-6-oxoocta-2,4-dienoate. Not identical with EC1.13.11.2 catechol 2,3-dioxygenase
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