Reference on EC 1.13.11.31 - arachidonate 12-lipoxygenase and Organism(s) Mus musculus and UniProt Accession O70582
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koshihara, Y.; Mizumura, M.; Murota, S.I.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells
Biochim. Biophys. Acta
712
42-47
1982
Mus musculus
McDonnell, M.; Davis, W.; Li, H.; Funk, C.D.
Characterization of the murine epidermal 12/15-lipoxygenase
Prostaglandins Other Lipid Mediat.
63
93-107
2001
Mus musculus
Krieg, P.; Kinzig, A.; Ress-Lschke, M.; Vogel, S.; Vanlandingham, B.; Stephan, M.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
12-Lipoxygenase isoenzymes in mouse skin tumor development
Mol. Carcinog.
14
118-129
1995
Homo sapiens, Mus musculus
Nie, D.; Tang, K.; Diglio, C.; Honn, K.V.
Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase
Blood
95
2304-2311
2000
Homo sapiens, Mus musculus, Rattus norvegicus
Siebert, M.; Krieg, P.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes
Biochem. J.
355
97-104
2001
Mus musculus
Prasad, K.M.; Thimmalapura, P.R.; Woode, E.A.; Nadler, J.L.
Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability
Biochem. Biophys. Res. Commun.
308
427-432
2003
Mus musculus
Gronert, K.; Maheshwari, N.; Khan, N.; Hassan, I.R.; Dunn, M.; Laniado Schwartzman, M.
A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
J. Biol. Chem.
280
15267-15278
2005
Mus musculus
Feinmark, S.J.; Begum, R.; Tsvetkov, E.; Goussakov, I.; Funk, C.D.; Siegelbaum, S.A.; Bolshakov, V.Y.
12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses
J. Neurosci.
23
11427-11435
2003
Mus musculus
Gonzalez-Nunez, D.; Sole, M.; Natarajan, R.; Poch, E.
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells
Kidney Int.
67
178-186
2005
Mus musculus
Bolick, D.T.; Srinivasan, S.; Whetzel, A.; Fuller, L.C.; Hedrick, C.C.
12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kB
Arterioscler. Thromb. Vasc. Biol.
26
1260-1266
2006
Mus musculus
Wen, Y.; Gu, J.; Vandenhoff, G.E.; Liu, X.; Nadler, J.L.
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
Am. J. Physiol. Heart Circ. Physiol.
294
H1933-H1938
2008
Mus musculus, Sus scrofa
Assimes, T.L.; Knowles, J.W.; Priest, J.R.; Basu, A.; Borchert, A.; Volcik, K.A.; Grove, M.L.; Tabor, H.K.; Southwick, A.; Tabibiazar, R.; Sidney, S.; Boerwinkle, E.; Go, A.S.; Iribarren, C.; Hlatky, M.A.; Fortmann, S.P.; Myers, R.M.; Kuhn, H.; Risch, N.; Quertermous, T.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
Atherosclerosis
198
136-144
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Moran, J.L.; Qiu, H.; Turbe-Doan, A.; Yun, Y.; Boeglin, W.E.; Brash, A.R.; Beier, D.R.
A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier
J. Invest. Dermatol.
127
1893-1897
2007
Mus musculus (O70582), Mus musculus, Mus musculus A/J (O70582)
Walther, M.; Roffeis, J.; Jansen, C.; Anton, M.; Ivanov, I.; Kuhn, H.
Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms
Biochim. Biophys. Acta
1791
827-835
2009
Danio rerio, Mus musculus
Piao, Y.S.; Du, Y.C.; Oshima, H.; Jin, J.C.; Nomura, M.; Yoshimoto, T.; Oshima, M.
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency
Carcinogenesis
29
440-447
2008
Mus musculus
Chou, D.S.; Hsiao, G.; Lai, Y.A.; Tsai, Y.J.; Sheu, J.R.
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase
Free Radic. Biol. Med.
46
1197-1203
2009
Mus musculus
Middleton, M.K.; Zukas, A.M.; Rubinstein, T.; Kinder, M.; Wilson, E.H.; Zhu, P.; Blair, I.A.; Hunter, C.A.; Pure, E.
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis
Infect. Immun.
77
5690-5700
2009
Mus musculus, Mus musculus C57BL/6
Nagelin, M.H.; Srinivasan, S.; Nadler, J.L.; Hedrick, C.C.
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways
J. Biol. Chem.
284
31303-31314
2009
Mus musculus (P39654), Mus musculus
Kayama, Y.; Minamino, T.; Toko, H.; Sakamoto, M.; Shimizu, I.; Takahashi, H.; Okada, S.; Tateno, K.; Moriya, J.; Yokoyama, M.; Nojima, A.; Yoshimura, M.; Egashira, K.; Aburatani, H.; Komuro, I.
Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure
J. Exp. Med.
206
1565-1574
2009
Mus musculus
Dioszeghy, V.; Rosas, M.; Maskrey, B.H.; Colmont, C.; Topley, N.; Chaitidis, P.; Kuehn, H.; Jones, S.A.; Taylor, P.R.; ODonnell, V.B.
12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo
J. Immunol.
181
6514-6524
2008
Mus musculus, Mus musculus C57BL/6
Kroenke, G.; Katzenbeisser, J.; Uderhardt, S.; Zaiss, M.M.; Scholtysek, C.; Schabbauer, G.; Zarbock, A.; Koenders, M.I.; Axmann, R.; Zwerina, J.; Baenckler, H.W.; van den Berg, W.; Voll, R.E.; Kuehn, H.; Joosten, L.A.; Schett, G.
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis
J. Immunol.
183
3383-3389
2009
Mus musculus
Pallast, S.; Arai, K.; Wang, X.; Lo, E.H.; van Leyen, K.
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress
J. Neurochem.
111
882-889
2009
Mus musculus
Sears, D.D.; Miles, P.D.; Chapman, J.; Ofrecio, J.M.; Almazan, F.; Thapar, D.; Miller, Y.I.
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
PLoS ONE
4
e7250
2009
Mus musculus, Mus musculus C57BL6
Schurmann, K.; Anton, M.; Ivanov, I.; Richter, C.; Kuhn, H.; Walther, M.
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease
J. Biol. Chem.
286
23920-23927
2011
Homo sapiens, Mus musculus
Yeung, J.; Apopa, P.L.; Vesci, J.; Stolla, M.; Rai, G.; Simeonov, A.; Jadhav, A.; Fernandez-Perez, P.; Maloney, D.J.; Boutaud, O.; Holman, T.R.; Holinstat, M.
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
Thromb. Haemost.
110
569-581
2013
Homo sapiens, Mus musculus
Halade, G.V.; Kain, V.; Ingle, K.A.; Prabhu, S.D.
Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing
Am. J. Physiol. Heart Circ. Physiol.
313
H89-H102
2017
Mus musculus, Mus musculus C57BL/6J
Ibrahim, A.S.; Tawfik, A.M.; Hussein, K.A.; Elshafey, S.; Markand, S.; Rizk, N.; Duh, E.J.; Smith, S.B.; Al-Shabrawey, M.
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
Biochim. Biophys. Acta
1851
290-298
2015
Mus musculus (P39654), Mus musculus C57BL/6J (P39654)
Ackermann, J.A.; Hofheinz, K.; Zaiss, M.M.; Kroenke, G.
The double-edged role of 12/15-lipoxygenase during inflammation and immunity
Biochim. Biophys. Acta
1862
371-381
2017
Mus musculus (P39654)
Yeung, J.; Tourdot, B.E.; Fernandez-Perez, P.; Vesci, J.; Ren, J.; Smyrniotis, C.J.; Luci, D.K.; Jadhav, A.; Simeonov, A.; Maloney, D.J.; Holman, T.R.; McKenzie, S.E.; Holinstat, M.
Platelet 12-LOX is essential for FcgammaRIIa-mediated platelet activation
Blood
124
2271-2279
2014
Mus musculus, Homo sapiens (O75342), Homo sapiens
Suzuki, H.; Kayama, Y.; Sakamoto, M.; Iuchi, H.; Shimizu, I.; Yoshino, T.; Katoh, D.; Nagoshi, T.; Tojo, K.; Minamino, T.; Yoshimura, M.; Utsunomiya, K.
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy
Diabetes
64
618-630
2015
Mus musculus (P39654), Mus musculus C57BL/6 (P39654)
Rothe, T.; Gruber, F.; Uderhardt, S.; Ipseiz, N.; Roessner, S.; Oskolkova, O.; Blueml, S.; Leitinger, N.; Bicker, W.; Bochkov, V.N.; Yamamoto, M.; Steinkasserer, A.; Schett, G.; Zinser, E.; Kroenke, G.
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function
J. Clin. Invest.
125
1944-1954
2015
Homo sapiens (P16050), Homo sapiens, Mus musculus (P39654), Mus musculus, Mus musculus C57BL/6 (P39654)
Leiria, L.O.; Wang, C.H.; Lynes, M.D.; Yang, K.; Shamsi, F.; Sato, M.; Sugimoto, S.; Chen, E.Y.; Bussberg, V.; Narain, N.R.; Sansbury, B.E.; Darcy, J.; Huang, T.L.; Kodani, S.D.; Sakaguchi, M.; Rocha, A.L.; Schulz, T.J.; Bartelt, A.; Hotamisligil, G.S.; Hirshman, M.F.; van Leyen, K.; Goodyear, L.J.; Blueher, M.
12-Lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat
Cell Metab.
30
768-783.e7
2019
Homo sapiens, Mus musculus (P55249), Mus musculus
Ogawa, M.; Ishihara, T.; Isobe, Y.; Kato, T.; Kuba, K.; Imai, Y.; Uchino, Y.; Tsubota, K.; Arita, M.
Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway
FASEB J.
34
12492-12501
2020
Mus musculus (P39654)
Miyata, J.; Yokokura, Y.; Moro, K.; Arai, H.; Fukunaga, K.; Arita, M.
12/15-Lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice
Front. Immunol.
12
687192
2021
Mus musculus (P39654)
Mori, Y.; Kawakami, Y.; Kanzaki, K.; Otsuki, A.; Kimura, Y.; Kanji, H.; Tanaka, R.; Tsukayama, I.; Hojo, N.; Suzuki-Yamamoto, T.; Kawakami, T.; Takahashi, Y.
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice
J. Biochem.
168
455-463
2020
Mus musculus (P39655)
Adams, W.; Bhowmick, R.; Bou Ghanem, E.N.; Wade, K.; Shchepetov, M.; Weiser, J.N.; McCormick, B.A.; Tweten, R.K.; Leong, J.M.
Pneumolysin induces 12-lipoxygenase-dependent neutrophil migration during Streptococcus pneumoniae infection
J. Immunol.
204
101-111
2020
Homo sapiens, Mus musculus (P55249)
Dobrian, A.D.; Huyck, R.W.; Glenn, L.; Gottipati, V.; Haynes, B.A.; Hansson, G.I.; Marley, A.; McPheat, W.L.; Nadler, J.L.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice
Prostaglandins Other Lipid Mediat.
136
23-32
2018
Mus musculus (P39654), Mus musculus
